Immune Regulation News Volume 10.04 | Feb 2 2018

TOP STORY

Scientists Discover How Gene Mutation Triggers Immune Disease

Scientists discovered how a gene mutation affects T cell function to promote immune disorders and then tested a treatment based on the discovery—successfully fixing donated immune cells from a 16-year-old boy with an abnormally low level of white blood cells called lymphopenia. [Press release from Cincinnati Children’s Hospital Medical Center discussing online publication in Nature Communications] Press Release | Full Article

(Ranked by impact factor of the journal)

IL-6 Receptor Blockade Corrects Defects of XIAP-Deficient Regulatory T Cells

The authors showed that mouse Xiap^−/− regulatory T (Treg) cells and human XIAP-deficient Treg cells are defective in suppressive function. The Xiap^−/− Treg cell defect was linked partly to decreased SOCS1 expression. [Nat Commun] Full Article

CEACAM1 Controls IL-2-Dependent Regulatory T Cell Induction in Immune-Mediated Hepatitis

Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)^-/-CD4⁺ T cells showed impaired IL-2-mediated signal transducer and activator of transcription 5 phosphorylation, which correlated with a failure of naïve CEACAM1^-/-CD4⁺ T cell to convert into regulatory T cells in vitro. [Hepatology] Abstract

Anti–PD-1/Anti–CTLA-4 Efficacy in Melanoma Brain Metastases Depends on Extracranial Disease and Augmentation of CD8⁺ T Cell Trafficking

Cell depletion studies revealed that NK cells and CD8⁺ T cells were required for intracranial anti–PD-1/anti–CTLA-4 efficacy. Rather than enhancing CD8⁺ T cell activation and expansion within intracranial tumors, PD-1/CTLA-4 blockade dramatically increased the trafficking of CD8⁺ T cells to the brain. [Proc Natl Acad Sci USA] Abstract

Platelets Release Pathogenic Serotonin and Return to Circulation after Immune Complex-Mediated Sequestration

The authors scrutinized platelet responses to systemic immune complexes (ICs) in the absence of tissue and endothelial wall injury. Platelet activation by circulating ICs through a mechanism requiring expression of platelet Fcγ receptor IIA resulted in the induction of systemic shock. [Proc Natl Acad Sci USA] Abstract | Press Release

Stimulation of TNF Receptor Type 2 Expands Regulatory T Cells and Ameliorates Established Collagen-Induced Arthritis in Mice

Treatment with TNCscTNF80 increased arthritis-induced myelopoiesis. Little effect was seen on the infiltration rate of inflammatory immature myeloid cells and on the reduction of lymphoid cells in secondary lymphoid organs. Upon treatment, frequency of regulatory T cells in the CD4⁺ T-cell population was increased in both spleen and inguinal lymph nodes. [Cell Mol Immunol] Abstract

MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation

Using a Rag1-cre mouse knock-in to selectively delete Mll1 in developing lymphocytes, scientists showed that B cell, but not T cell, homeostasis depends on MLL1. Mll1^−/− B progenitors fail to differentiate efficiently through the pro- to pre-B cell transition, resulting in a persistent reduction in B cell populations. [J Immunol] Abstract

Down-Regulation of Guanylate Binding Protein 1 Causes Mitochondrial Dysfunction and Cellular Senescence in Macrophages

The authors explored the role of guanylate binding protein 1, an intracellular anti-microbial protein, in regulating polarization, metabolic reprogramming, and cellular aging of macrophages. [Sci Rep] Full Article

BANK1 Alters B Cell Responses and Influences the Interactions between B Cells and Induced T Regulatory Cells in Mice with Collagen-Induced Arthritis

Researchers investigated the roles of B cell scaffold protein with ankyrin repeats 1 (BANK1) in collagen-induced arthritis and the interaction between B cells and induced T regulatory cells. [Arthritis Res Ther] Full Article

Collagen-Derived Peptides Modulate CD4⁺ T-Cell Differentiation and Suppress Allergic Responses in Mice

Investigators tested the effects of collagen-peptide ingestion on allergic response and the effects of collagen-derived oligopeptides on CD4⁺ T-cell differentiation. [Immun Inflamm Dis] Abstract

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Epigenetic Control of CD8⁺ T Cell Differentiation

Researchers review the epigenetic processes that direct CD8⁺ T cell differentiation and function. They focus on epigenetic modification of DNA and associated histones at genes and their regulatory elements. [Nat Rev Immunol] Abstract

Epigenetic Regulation in B-Cell Maturation and Its Dysregulation in Autoimmunity

The authors summarize current research progress in epigenetic modifications contributing to B-cell activation and differentiation, especially under autoimmune conditions such as lupus, rheumatoid arthritis and type 1 diabetes. [Cell Mol Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation research field.

Corvus Pharmaceuticals Announces Presentation of New Data from Preclinical Study of Novel T-Cell Signaling Pathway Inhibitor

Corvus Pharmaceuticals, Inc. announced new data from an ongoing preclinical study of its investigational small molecule T-cell signaling pathway inhibitor. [Press release from Corvus Pharmaceuticals, Inc. discussing research to be presented at the 10^th Annual T-Cell Lymphoma Forum, La Jolla] Press Release

Celgene Corporation to Acquire Juno Therapeutics, Inc., Advancing Global Leadership in Cellular Immunotherapy

Celgene Corporation and Juno Therapeutics, Inc. announced the signing of a definitive merger agreement in which Celgene has agreed to acquire Juno. Under the terms of the merger agreement, Celgene will pay $87 per share in cash, or a total of approximately $9 billion, net of cash and marketable securities acquired and Juno shares already owned by Celgene. [Celgene Corporation] Press Release

SAB Capra Awarded $225K from NIH

SAB Capra, LLC has been awarded a $225,000 grant from the National Institutes of Health (NIH) to advance its novel immunotherapy platform targeting pandemic influenza in collaboration with Utah State University. [SAB Capra, LLC] Press Release

Syndax Announces Immuno-Oncology Clinical Trial Collaboration with AstraZeneca

Syndax Pharmaceuticals, Inc. announced a new clinical collaboration with AstraZeneca to evaluate the safety and efficacy of AstraZeneca’s durvalumab, a human monoclonal antibody directed against programmed death-ligand 1, in combination with SNDX-6352, Syndax’s monoclonal antibody inhibitor of Colony-Stimulating Factor 1 Receptor, across a variety of solid tumors. [Syndax Pharmaceuticals, Inc.] Press Release

Partner Therapeutics (PTx) Acquires Leukine^® from Sanofi

Partner Therapeutics, Inc. announced that it has acquired the global rights to develop, manufacture, and commercialize Leukine from Sanofi. [Partner Therapeutics, Inc.] Press Release

Bulgaria in the Cold as European Union Freezes Its Funding

European Union science ministers are due to meet in their bloc’s poorest member state — Bulgaria — to discuss future EU research policy. For the host nation, it was supposed to be a chance to showcase its ambitious plans to boost economic growth by attracting international research institutes to the country. [Nature News] Editorial

Kid Co-Authors in South Korea Spur Government Probe

The South Korean government is expanding an investigation into researchers who named their children as co-authors on papers. The extended probe comes after a government report identified 82 academic papers on which authors had named their children or relatives — many of them in middle or high school — as co-authors on the publications. [Nature News] Editorial

NEW LabRoots: 3^rd Annual Microbiology and Immunology Virtual Event
September 12-13, 2018
Online

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellowship – Immune Checkpoint Therapy (Canadian Nuclear Laboratories)

Research Technologist – Cell Separation (STEMCELL Technologies Inc.)

Scientist – Immunology (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Myeloid Cells and Type I Interferon Responses (The Wistar Institute)

Laboratory Head – In Vivo Pharmacology (Boehringer Ingelheim)

PhD Positions – Immunology (Regensburg Center for Interventional Immunology)

Postdoctoral Fellow – Regulation of Platelet Mediated Complications (NYU School of Medicine)

Research Scientist – Cellular and Translational Immunology (University of Virginia)

Postdoctoral Scholar – Immunology (Pennsylvania State University)

Postdoctoral Positions – Innate Immunity (University of Connecticut)

Postdoctoral Research Fellow – Inflammation and Immuno-Oncology (Yale School of Medicine)

Postdoctoral Training Opportunity – Infection and Immunity (Institut Pasteur of Shanghai – Chinese Academy of Sciences)

Assistant, Associate, or Full Member – Cancer Immunology (Fred Hutchinson Cancer Research Center)

Research Fellow Position – Immunology Research (ShanghaiTech University)

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