Immune Regulation News Volume 10.08 | Mar 2 2018

TOP STORY

Regulation of Age-Associated B Cells by IRF5 in Systemic Autoimmunity

Researchers found that the lupus syndrome that developed in SWEF-deficient mice was accompanied by the accumulation of age-associated B cells that produced autoantibodies after stimulation. [Nat Immunol] Abstract

(Ranked by impact factor of the journal)

Mast Cells Regulate CD4⁺ T Cell Differentiation in Absence of Antigen Presentation

The authors dissected the mechanism of actions of nicotinamide adenine dinucleotide (NAD)⁺, and determined the impact of antigen presenting cells on NAD⁺-mediated T cell activation. [J Allergy Clin Immunol] Abstract

Surface Receptor Toso Controls B Cell–Mediated Regulation of T Cell Immunity

Investigators indicated that Toso was involved in the differentiation/maintenance of regulatory B cells by fine-tuning B cell receptor-activation thresholds. [J Clin Invest] Abstract | Full Article

FcαRI Co-Stimulation Converts Human Intestinal CD103⁺ Dendritic Cells into Pro-Inflammatory Cells through Glycolytic Reprogramming

The authors showed that immunoglobulin A immune complexes, which are present after bacterial infection of the lamina propria, are important for the induction of inflammation by the human CD103⁺SIRPα⁺ dendritic cell subset. [Nat Commun] Full Article

Bifunctional Immune Checkpoint-Targeted Antibody-Ligand Traps that Simultaneously Disable TGFβ Enhance the Efficacy of Cancer Immunotherapy

a-cytotoxic T-lymphocyte antigen (CTLA)-4-transforming growth factor-β (TGFβ)RIIecd was more effective in reducing tumor-infiltrating Tregs and inhibiting tumor progression compared with CTLA-4 antibody. [Nat Commun] Abstract | Press Release

Treg Cells Limit IFN-γ Production to Control Macrophage Accrual and Phenotype during Skeletal Muscle Regeneration

Scientists addressed how Treg cells rein in macrophages during regeneration of murine muscle after acute injury with cardiotoxin. [Proc Natl Acad Sci USA] Abstract

Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells

Researchers identified hypermethylated in cancer 1 (HIC1) as a transcription factor upregulated early during the differentiation of human induced Treg cells. [Cell Rep] Full Article | Graphical Abstract | Press Release

Transcription Factor YY1 Is Essential for iNKT Cell Development

Scientists report that the transcription factor Yin Yang 1 (YY1) is essential for invariant natural killer T (iNKT) cell formation. Thymocytes lacking YY1 displayed a block in iNKT cell development at the earliest progenitor stage. [Cell Mol Immunol] Abstract

FoxP3 Isoforms and PD-1 Expression by T Regulatory Cells in Multiple Sclerosis

Researchers propose a strategy to identify potentially functional and suppressive Treg cells in an autoimmune disease like multiple sclerosis. [Sci Rep] Full Article

Loss of Epigenetic Regulator TET2 and Oncogenic KIT Regulate Myeloid Cell Transformation via PI3K Pathway

Investigators showed that loss of TET2-induced PI3K activation and -increased proliferation is rescued by targeting the p110α/δ subunits of PI3K. RNA-Seq revealed a hyperactive c-Myc signature in Tet2^–/– cells, which is normalized by inhibiting PI3K signaling. [JCI Insight] Full Article

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Lipid Droplets as Immune Modulators in Myeloid Cells

The authors review recent studies that report on the role of lipid droplets in the modulation of immune cell function, primarily focusing on myeloid cells, such as macrophages and dendritic cells. [Trends Immunol] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation research field.

Aldeyra Therapeutics Announces Agreement with Johnson & Johnson Innovation to Advance Novel Immune-Modulating Drugs for Systemic Inflammatory Diseases

Aldeyra Therapeutics, Inc. announced that it has entered into a collaborative research agreement with Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies of Johnson & Johnson. Aldeyra plans to collaborate with Janssen on the development of novel drugs designed to sequester pro-inflammatory aldehyde mediators, a new class of therapeutic targets. [Aldeyra Therapeutics, Inc.] Press Release

OSE Immunotherapeutics Granted Approval to Resume Patient Accrual in U. S. for Phase III Tedopi^® Clinical Trial in Advanced Non-Small Cell Lung Cancer Patients Following Immune Checkpoint Inhibitor Treatment

OSE Immunotherapeutics announced that the first approvals to resume patient accrual in the global Tedopi^® Phase III trial have been granted in the United States by the Institutional Review Boards. Recruitment into this trial is based on a revised protocol focused on patients with non-small cell lung cancer who have failed a previous treatment with PD-1/PD-L1 immune checkpoint inhibitors. [OSE Immunotherapeutics] Press Release

Idera Pharmaceuticals Announces Launch of Global Phase III Trial Evaluating IMO-2125 in Combination with Ipilimumab for the Treatment of Anti-PD-1 Refractory Melanoma (ILLUMINATE 301)

Idera Pharmaceuticals, Inc. announced the start of a Phase III global, multi-center, open-label clinical trial to evaluate the efficacy and safety of intratumoral IMO-2125 in combination with ipilimumab versus ipilimumab alone in subjects with anti-PD-1 refractory melanoma. [Idera Pharmaceuticals, Inc.] Press Release

EU Research Chief’s Next Act: Changing the Future of Academic Publishing

Robert-Jan Smits, one of Europe’s most powerful figures in research, has been appointed as a special envoy on open science at the European Commission, to help push efforts to make all publicly funded research in Europe freely available by 2020. [Science|Business] Editorial

Indian Scientist’s Sacking Spotlights Sexual Harassment

Female scientists in India hope that more academics will report sexual harassment without fear of jeopardizing their career or reputation, after a prominent biologist was sacked for allegedly harassing a staff member. [Nature News] Editorial

Here’s How the Scientists Running for Office Are Doing

They’re trained problem-solvers, but they have to learn to move beyond data to run successful campaigns. [The Atlantic] Editorial

Canadian Science Wins Billions in New Budget

Canadian Prime Minister Justin Trudeau’s administration released its 2018 budget and scientists couldn’t be happier. It includes almost CAD 4 billion (USD 3.1 billion) in new funding for science over the next five years, a significant portion of which will go to the country’s three granting councils. [Nature News] Editorial

NEW Aegean Conferences: 1^st International Conference on Oral Mucosal Immunity and Microbiome
September 26-October 1, 2018
Crete, Greece

Visit our events page to see a complete list of events in the community.

NEW Professor – Translational Immunology (Rheinische Friedrich-Wilhelms-Universitat Bonn)

Research Technologist – Cell Separation (STEMCELL Technologies Inc.)

Postdoctoral Fellow – Immunology and iPSCs (Stanford University)

Postdoctoral Associate Position – Tumor Immunology/Immunotherapy (Duke Cancer Institute)

Postdoctoral Scientist Opportunities – Biomedical Research (Cedars-Sinai)

Postdoctoral Fellowship – Immune Checkpoint Therapy (Canadian Nuclear Laboratories)

Postdoctoral Fellow – Myeloid Cells and Type I Interferon Responses (The Wistar Institute)

Postdoctoral Fellow – Regulation of Platelet Mediated Complications (NYU School of Medicine)

Research Scientist – Cellular and Translational Immunology (University of Virginia)

Postdoctoral Training Opportunity – Infection and Immunity (Institut Pasteur of Shanghai – Chinese Academy of Sciences)

Assistant, Associate, or Full Member – Cancer Immunology (Fred Hutchinson Cancer Research Center)

Research Fellow Position – Immunology Research (ShanghaiTech University)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

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