Immune Regulation News 10.18 May 18, 2018 | |
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TOP STORYHigh-fiber diet-fed mice exhibited altered bone marrow hematopoiesis, characterized by enhanced generation of Ly6c− patrolling monocytes, which led to increased numbers of alternatively activated macrophages with a limited capacity to produce the chemokine CXCL1 in the airways. [Immunity] Full Article | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers generated CARD9S12N knock-in mice and found that CARD9S12N facilitated the induction of type 2 immune responses after engagement of C-type lectin receptors. [Nat Immunol] Abstract Tumor-associated neutrophils inhibited the proliferation of murine CD27− Vγ6+ γδ17 T cells via induction of oxidative stress, thereby preventing them from constituting the major source of pro-tumoral IL-17 in the tumor microenvironment. [PLoS Biol] Full Article CD8 Follicular T Cells Promote B Cell Antibody Class Switch in Autoimmune Disease Investigators showed that CD8 T cells acquire a CD4 T follicular helper profile in the absence of functional regulatory T cells in both the IL-2-deficient and scurfy mouse models. [J Immunol] Abstract Scientists investigated the mechanisms of Th2-mediated immune responses in mouse bone marrow-derived basophils and mast cells via stimulation with the cysteine protease allergen Der f 1. [Sci Rep] Full Article γδTCR Regulates Production of Interleukin-27 by Neutrophils and Attenuates Inflammatory Arthritis Investigators demonstrated that γδ T cell blockade has a protective effect on arthritis incidence and severity by preventing neutrophil accumulation in the blood, spleen and bone marrow as well as by reducing neutrophil infiltration into the joints. [Sci Rep] Full Article Ability of γδ T Cells to Modulate the Foxp3 T Cell Response Is Dependent on Adenosine Activated γδ T cells expressed adenosine receptors at high levels, which enabled them to deprive Foxp3+ T cells of adenosine, and inhibited their expansion. [PLoS One] Full Article The authors evaluated the function of miR-142-5p on cancer immunity to induce apoptosis in human non-small cell lung cancer (NSCLC) and its mechanism. miR-142-5p expression was upregulated, and CD4+ T cell levels were reduced in patients with NSCLC. [Oncol Rep] Abstract | Download Full Article IKKα Deficiency Disrupts the Development of Marginal Zone and Follicular B Cells The loss of IKKα produces a significant decline in the percentage of immature B lymphocytes, mature marginal zone B cells, and follicular B cells along with a severe disruption of splenic architecture of marginal and follicular zones. [Genes Immun] Abstract Glioblastoma-Targeted CD4+ CAR T Cells Mediate Superior Antitumor Activity Researchers investigated the differential antitumor effect of CD4+ and CD8+ CAR T cells targeting glioblastoma-associated antigen IL-13 receptor α2. [JCI Insight] Full Article Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSRegulation of Macrophage Immunometabolism in Atherosclerosis The authors explore how factors central to the plaque microenvironment shape the metabolic rewiring of macrophages in atherosclerosis as well as how these metabolic shifts in turn alter macrophage immune-effector and tissue-reparative functions. [Nat Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSZymeworks and Daiichi Sankyo Expand Immuno-Oncology Collaboration Focused on Bispecific Antibodies Zymeworks Inc. and Daiichi Sankyo Company, Limited announced that they entered into a new license agreement, building upon their 2016 cross-licensing and collaboration agreement. [Zymeworks Inc.] Press Release Syntimmune, Inc. announced positive preliminary results from its Phase Ib proof-of-concept trial of SYNT001 in patients with pemphigus vulgaris and pemphigus foliaceus. [Syntimmune, Inc.] Press Release CStone’s Anti-CTLA-4 Antibody CS1002 Filed for Clinical Trial Approval in Australia CStone Pharmaceuticals (Suzhou) Co., Ltd announced that an investigational new drug filing has been submitted to Human Research Ethics Committees of the Ashford Cancer Center in Australia for CS1002, an independently-developed investigational cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) inhibitor. [CStone Pharmaceuticals Co., Ltd] Press Release | |
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POLICY NEWSUK’s Powerful Funding Body Takes Shape The United Kingdom’s newly minted unified funding agency has released the first outline of its strategy. The long-awaited document gives the nation’s researchers an insight into how the mega-funding agency — which will command a budget of £6 billion (US$8 billion) — will work. [Nature News] Editorial Chief Academic Officer Accused in Ongoing Research Scandal at UCL Prominent geneticist David Latchman, the chief academic and administrative officer of Birkbeck, University of London, has been accused of “recklessness” for his role in an ongoing research scandal, according to a report described by The Telegraph. [The Scientist] Editorial Europe’s Open-Access Drive Escalates As University Stand-Offs Spread Bold efforts to push academic publishing towards an open-access model are gaining steam. Negotiators from libraries and university consortia across Europe are sharing tactics on how to broker new kinds of contracts that could see more articles appear outside paywalls. [Nature News] Editorial
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EVENTSNEW Making it Personal: Cancer Precision Medicine Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellow – Immunology (Boston University School of Medicine) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Fellow – Innate Immune Signaling (Houston Methodist Research Institute) Computational Scientist – Immune System (Karolinska Institutet) Immunologist – Project Research (The Francis Crick Institute) Postdoctoral Fellow/Research Associate – Immune Modulatory Therapies (Houston Methodist Hospital) Research Scientist – Biomarker Development (Kymab) Postdoctoral Fellow – Immune Suppression Mechanisms in Myeloid Cells (AstraZeneca) Postdoctoral Position – Cancer, Immunotherapy, and Fibrosis (University of Alabama at Birmingham) Postdoctoral Fellow – Immunology and iPSCs (Stanford University) Postdoctoral Associate Position – Tumor Immunology/Immunotherapy (Duke Cancer Institute) Assistant, Associate, or Full Member – Cancer Immunology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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