Immune Regulation News 10.21 June 8, 2018 | |
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TOP STORYPhycoerythrin immunization of mouse strains with Ighb immunoglobulin (Ig) variable heavy chain genes elicited affinity-matured switched Ig memory B cells that declined with time, while the comparable population from an Igha strain was numerically stable. [Immunity] Abstract | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Induction of Anergic or Regulatory Tumor-Specific CD4+ T Cells in the Tumor-Draining Lymph Node Scientists showed, using a genetically engineered lung adenocarcinoma mouse model, that naive tumor-specific CD4+ T cells are activated and proliferate in the tumor-draining lymph node but do not differentiate into effectors or accumulate in tumors. [Nat Commun] Full Article Investigators showed that the induction of cross-presentation by plasmacytoid dendritic cells is regulated by mitochondria through a reactive oxygen species-dependent mechanism, involving pH alkalization and antigen protection. [Nat Commun] Full Article IL-10 Receptor Signaling Empowers Regulatory T Cells to Control Th17 Responses and Protect from GN Compared with controls, mice with IL-10Ra-/- Tregs showed a spontaneously overshooting Th17 immune response. This hyper-Th17 phenotype was further boosted during glomerulonephritis (GN) and associated with aggravated renal injury. Abrogation of IL-10Ra signaling in Tregs increased dendritic cell activation and production of Th17-inducing cytokines. [J Am Soc Nephrol] Abstract | Graphical Abstract Researchers determined the impact of therapeutic Treg administration on systemic and cardiac inflammation and remodeling in coxsackievirus B3 (CVB3) – induced myocarditis. Coculture of Treg cells with splenocytes isolated from mice three day post-CVB3 infection demonstrated the ability of Treg cells to modulate monocyte differentiation in favor of the anti-inflammatory Ly6ClowCCR2lowCx3Cr1high subset. [FASEB J] Abstract The authors used Batf3-/- mice to investigate the impact of CD103+ dendritic cell (DC) and CD8α+ DC deficiency on anti-vaccinia virus (VacV) CD8+ T cell responses. They found that Batf3-/- mice were more susceptible to VacV infection, exhibiting profound weight loss, which correlated with impaired accumulation of IFN-γ-producing CD8+ T cell in the lungs. [J Virol] Abstract Researchers revealed a novel phenomenon that mast cells play a vital role in protecting cornea against fungal infection through degranulation that promotes neutrophil infiltration via stimulating ICAM-1 production and limbal vascular dilation and permeability. [Sci Rep] Full Article Scientists used IL-9 receptor deficient mice on BALB/c and C57BL/6 genetic background to dissect effector and regulatory functions of IL-9 during infection with the parasitic nematode Strongyloides ratti. [Sci Rep] Full Article The authors investigated the effects of SM934 on ulcerative colitis both in vivo and in vitro. SM934 administration dose-dependently decreased the mRNA and protein levels of dextran sulfate sodium (DSS)-induced pro-inflammatory cytokines, and the percentage of macrophages and neutrophils in colon tissues. [Acta Pharmacol Sin] Abstract The authors showed that genetic ablation of colony-stimulating factor-1 (CSF1) in colorectal cancer cells reduces the influx of immunosuppressive CSF1R+ tumor-associated macrophages (TAMs) within tumors. This reduction in CSF1-dependent TAMs resulted in increased CD8+ T cell attack on tumors, but its effect on tumor growth was limited by a compensatory increase in Foxp3+ Treg cells. [JCI Insight] Full Article | Press Release Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSAntigen-Specific Regulatory T-Cell Responses against Aeroantigens and Their Role in Allergy Allergies result from a loss of tolerance against harmless antigens characterized by formation of allergen-specific Th2 cells and IgE. Tolerance is often described as a balance between harmful Th2 cells and various types of protective “regulatory” T cells. The authors discuss the experimental evidence for the various tolerance mechanisms described. [Mucosal Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSTxCell Names Lonza As Its CAR-Treg Cellular Product Manufacturer TxCell SA and Lonza Pharma & Biotech announced entering into a Master Service Agreement for the manufacture of TxCell’s HLA-A2 CAR-Treg cellular product (TX200), which is in development for the prevention of chronic rejection after organ transplantation. [TxCell SA] Press Release U.S. Patent Office Allows New CEL-SCI Patents for LEAPS Vaccine Platform Technology CEL-SCI Corporation announced the U.S. Patent and Trademark Office has allowed two new US patents for the Company’s LEAPS platform technology. These patents are titled “Method for Inducing an Immune Response and Formulations Thereof” and ” Method for Inducing an Immune Response against avian, swine, Spanish, H1N1, H5N9 influenza viruses and formulations”. CEL-SCI’s patented inventions relate to methods for diagnosing, preventing, and treating disease by generating or modulating the immune response through the use of specific peptides. [CEL-SCI Corporation] Press Release | |
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POLICY NEWSGo for Launch: A Former Astronaut Becomes Spain’s Science Minister Spain has a ministry of science again—and none other than the first Spanish astronaut is leading it. The new transition government led by socialist Pedro Sánchez announced that Pedro Duque, who visited space twice, will be at the helm of the newly created Ministry for Science, Innovation, and Universities. The announcement was cheered by the Spanish scientific community, which has long suffered from declining budgets and bureaucratic hurdles. [ScienceInsider] Editorial Scientists Fare Poorly in Super Tuesday Primary Vote Science-minded candidates seeking seats in the next U.S. Congress took a drubbing from their Democratic opponents in a raft of primary elections across the country. [ScienceInsider] Editorial Chile, Keen to Become a Knowledge Society, Creates a Ministry of Science Scientists in Chile have welcomed a decision by Congress to create a science ministry. Many researchers hope that a dedicated ministry will give science more prominence and better-coordinated policies—provided the ministry’s budget matches the government’s ambitions to “bring Chile towards an information and knowledge society,” as Gonzalo Blumel, the country’s minister secretary-general of the presidency, put it in a statement issued after the 31 May vote. [ScienceInsider] Editorial
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EVENTSNEW 30th EORTC-NCI-AACR Symposium Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Immunologist – Allergic Inflammation Discovery Performance Unit (GlaxoSmithKline) NEW Postdoctoral Research Fellow – Human Systems Immunology (University of Oslo) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) PhD Student Positions – Immunology (Multiple Locations) Postdoctoral Position – Immunology (Uppsala University) Postdoctoral Research Scientist – Immunology (Lilly) Postdoctoral Fellowship – Immunology (University of South Carolina) Postdoctoral Researcher in Immunology/Vaccinology (Karolinska Institutet) Postdoctoral Fellow – Immunology (Boston University School of Medicine) Postdoctoral Fellow – Innate Immune Signaling (Houston Methodist Research Institute) Postdoctoral Associate Position – Tumor Immunology/Immunotherapy (Duke Cancer Institute) Assistant, Associate, or Full Member – Cancer Immunology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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