Immune Regulation News 10.31 August 17, 2018 | |
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TOP STORYT Cell-Intrinsic IL-1R Signaling Licenses Effector Cytokine Production by Memory CD4 T Cells Researchers demonstrated that successful lineage commitment does not translate into productive effector functions in the absence of IL-1R signaling. Acute abrogation of IL-1R signaling in vivo resulted in reduced IL-17A production by intestinal Th17 cells. [Nat Commun] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Epigenetic Dysregulation of Naive CD4+ T-Cell Activation Genes in Childhood Food Allergy Using integrated DNA methylation and transcriptomic profiling, the authors found that polyclonal activation of naive CD4+ T cells through the T cell receptor results in poorer lymphoproliferative responses in children with immunoglobulin E-mediated food allergy. [Nat Commun] Full Article Researchers aimed to investigate whether the shift from Treg to Th17 could specifically occur during the course of drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms and to elucidate which subsets of monocytes could be involved in the shift. [Clin Exp Allergy] Abstract Scientists demonstrated that IL-21 preserves a crucial central memory-like NKT subset and enhances its antitumor effector functionality. They found that following antigenic stimulation with α-galactosylceramide, CD62L+ NKTs both expressed IL-21R and secreted IL-21, each at significantly higher levels than CD62L− cells. [J Immunol] Abstract In combination with IL2, D18 treatment is specific for T regs in stabilizing NF-κB-inducing kinase protein, the activator of non-canonical NF-κB signaling, inducing translocation of RelB from cytosol to nucleus, increasing cell cycle entry, and increasing cell numbers. [Sci Rep] Full Article Scientists revealed novel insights into septin 7 function by identification of DOCK8 as an interaction partner in primary blood-derived lymphocytes. [Sci Rep] Full Article Investigators report that E3 expression in human monocytes alters TLR2- and TLR8-dependent cytokine induction, and particularly inhibits IL-6. Using MS, researchers identified DExD/H-box helicase 9 as an E3 target. [J Biol Chem] Abstract | Full Article The authors used the Vm24 toxin as a tool to investigate the molecular events that follow Kv1.3 blockade specifically on human CD4+ TEM cells as they are actively involved in inflammation and are key mediators of autoimmune diseases. [Cell Commun Signal] Full Article Altered Frequency of Th17 and Treg Cells in New-Onset SLE Patients The frequency of T helper 17 (Th17) and Treg cells, the expression of interleukin-17 A (IL-17A) among Th17 cell, the plasma level of IL-17A, the expression of retinoid-related orphan nuclear receptor γt and forkhead box P3 genes were all significantly higher in systemic lupus erythematosus (SLE) patients. [Eur J Clin Invest] Abstract Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSInvestigators synthesized a new perspective on the role of Foxp3 as a dynamically expressed gene, and thereby revisited the molecular mechanisms for the transcriptional regulation of Foxp3. [Clin Exp Immunol] Abstract Regulation of T Cell Immunity by Cellular Metabolism The authors summarize the main T cell metabolic pathways and the important factors participating in T cell metabolic programming during T cell homeostasis, differentiation, and function. [Front Med] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSMustang Bio, Inc. and St. Jude Children’s Research Hospital announced that they have partnered and entered into an exclusive worldwide license agreement for the development of a first-in-class ex vivo lentiviral gene therapy for the treatment of X-linked severe combined immunodeficiency, also known as bubble boy disease. [Mustang Bio, Inc.] Press Release RXi Pharmaceuticals Corporation announced that it has entered into a research collaboration with the Karolinska Institutet. [RXi Pharmaceuticals] Press Release AgeX Therapeutics Acquires Technology to Regulate Immune Tolerance AgeX Therapeutics, Inc. announced that it has acquired certain patents and patent applications from Escape Therapeutics relating primarily to the use of the HLA-G gene to suppress rejection of transplanted cells and tissues. [AgeX Therapeutics, Inc.] Press Release | |
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POLICY NEWSTop Geneticist Loses £3.5-Million Grant in First Test of Landmark Bullying Policy One of the world’s largest research-funding charities has revoked a £3.5-million (US$4.5-million) grant awarded to a top cancer geneticist, Nazneen Rahman, following allegations that she bullied scientists and other staff when she worked at the Institute of Cancer Research in London. [Nature News] Editorial Researcher at the Center of an Epic Fraud Remains an Enigma to Those Who Exposed Him The first thing that went through Alison Avenell’s head when she heard Yoshihiro Sato had died was that it might be a trick. It was March 2017, and in the previous years, Avenell, a clinical nutritionist at the University of Aberdeen in the United Kingdom, had spent thousands of hours combing through Sato’s papers, together with three colleagues in New Zealand. They had discovered that Sato, a bone researcher at a hospital in southern Japan, had fabricated data for dozens of clinical trials published in international journals. [ScienceInsider] Editorial What Pakistan’s New Government Means for Science Pakistan is reeling from a political earthquake — and researchers are both nervous and excited. On 18 August, the former cricket superstar Imran Khan is expected to be sworn in as prime minister. The incoming administration promises to use science to alleviate poverty, but it is facing an imminent economic crisis. [Nature News] Editorial The NIH Loosens Grip on Gene Therapy Trials The directors of the National Institutes of Health (NIH) and the US FDA propose limiting the role of the NIH in assessing proposals for gene therapy experiments, the two explain in a commentary in the New England Journal of Medicine. [The Scientist] Editorial
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EVENTSNEW International Conference on Cellular Therapies: Focus on Immune Based Therapeutic Concepts Visit our events page to see a complete list of events in the community.
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