Immune Regulation News 10.32 August 24, 2018 | |
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TOP STORYScientists found that the regulation of natural killer (NK) cell function by the glucocorticoid receptor was required for host survival after infection with mouse cytomegalovirus. [Nat Immunol] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Investigators found that mutant phosphatidylinositol-3-OH kinase catalytic subunit p110δ (PI3Kδ) led to co-stimulatory receptor ICOS-independent increases in the abundance of follicular helper T cells and germinal-center (GC) B cells, disorganized GCs and poor class-switched antigen-specific responses to immunization, associated with altered regulation of the transcription factor FOXO1 and pro-apoptotic and anti-apoptotic members of the BCL-2 family. [Nat Immunol] Abstract CD28 Blockade Controls T Cell Activation to Prevent Graft-versus-Host Disease in Primates The authors investigated FR104, an antagonistic CD28-specific pegylated-Fab′, in the nonhuman primate graft-versus-host disease model and completed a multiparameter interrogation comparing it with CTLA4-Ig, with and without sirolimus, including clinical, histopathologic, flow cytometric, and transcriptomic analyses. [J Clin Invest] Full Article | Press Release Immunomodulatory Role of Keratin 76 in Oral and Gastric Cancer Researchers showed that genetic ablation of keratin 76 in mice leads to spleen and lymph node enlargement, an increase in Tregs and high levels of pro-inflammatory cytokines. [Nat Commun] Full Article The authors investigated how APRIL impacts immune Tregs and directly contributes to the immunosuppressive multiple myeloma bone marrow microenvironment. [Leukemia] Abstract Researchers showed that sprouty 1 and 2 (Spry1/2) molecules regulate the survival and function of memory CD8+ T cells. Spry1/2 double-knockout ovalbumin (OVA)-specific CD8+ T cells (OT-I cells) mounted more vigorous autoimmune diabetes than WT OT-I cells when transferred to mice expressing OVA in their pancreatic β-islets. [Proc Natl Acad Sci USA] Abstract | Press Release Circadian Clock Protein BMAL1 Regulates IL-1β in Macrophages via NRF2 Investigators reveal that core molecular clock protein, BMAL1, controls the mRNA expression of Nrf2 via direct E-box binding to its promoter to regulate its activity. Deletion of Bmal1 decreased the response of NRF2 to LPS challenge, resulting in a blunted antioxidant response and reduced synthesis of glutathione. [Proc Natl Acad Sci USA] Abstract | Full Article | Press Release The authors demonstrated that among the suite of transcripts induced in activated natural killer (NK) cells, interferon-α is necessary and sufficient to promote expression of its downstream transcription factors STAT1, STAT2, and IRF9, via an auto-regulatory, feedforward loop. [Cell Rep] Full Article | Graphical Abstract Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance Mechanisms implicated in robust transplantation tolerance at the cellular level can be broadly categorized into those that inhibit alloreactive T cells intrinsically or extrinsically through regulation. Researchers investigated whether additional population-level mechanisms control T cells by examining whether therapeutically induced peripheral transplantation tolerance could influence T cell populations’ avidity for alloantigens. [Cell Rep] Full Article | Graphical Abstract Scientists showed that NLRC3 plays an intrinsic role by suppressing the CD4+ T cell phenotype in lung and spleen, including differentiation, activation, and proliferation. [PLoS Pathog] Full Article Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSBiomaterial-Assisted Targeted Modulation of Immune Cells in Cancer Treatment The authors analyze thus-far developed immunomaterials for targeted modulation of dendritic cells, T cells, tumor-associated macrophages, myeloid-derived suppressor cells, [Nat Mater] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSbluebird bio, Inc. announced a collaboration to research, develop and commercialize products for the treatment of cancer using cell therapy. Gritstone Oncology will leverage its proprietary EDGE™ artificial intelligence platform to analyze specific tumor types to identify tumor-specific targets and natural T-cell receptors directed to those targets for use in bluebird bio’s established cell therapy platforms. [bluebird bio, Inc.] Press Release Alberta Biotech Company Receives Canadian Government Funding for Immuno-Oncology Project Edmonton’s General Intermediates of Canada Inc. announced that they have received conditional funding from the National Research Council of Canada Industrial Research Assistance Program related to their discovery of a new immuno-oncology compound that could play a role in the fight against cancer. [Edmonton’s General Intermediates of Canada Inc. (PR Newswire Association LLC.)] Press Release Viela Bio Announces Start of First Clinical Trial Viela Bio announced the start of the company’s first clinical trial, a Phase I, first-in-human clinical trial of VIB9600, which is being developed for the treatment of adult patients with immune mediated diseases. [Viela Bio (PR Newswire Association LLC.)] Press Release Lion TCR Pte. Ltd. received approval from Health Sciences Authority, Singapore, for its Phase I/II multicenter clinical study of its product candidate for treatment of relapsed liver cancer post-liver transplantation. [Lion TCR Pte. Ltd.] Press Release Nuevolution AB announced the identity of its “Cytokine X” program being a lead discovery program targeting inhibition of Interleukin IL-17A using small molecules. [Nuevolution AB] Press Release | |
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POLICY NEWSSenate Approves $2B Boost for NIH in $850B+ Spending Bill For the fourth year in a row, the Senate has approved a significant increase in funding for the National Institutes of Health (NIH). [Fierce Biotech] Editorial The National Institutes of Health (NIH) is investigating roughly a half-dozen research institutions based on suspicions that researchers with federal grants failed to disclose significant financial contributions from foreign governments. [STAT News] Editorial Hundreds of Chimps at the NIH Await Retirement. This Senator Wants to Help Sen. Bill Cassidy is trying to help hundreds of chimpanzees enjoy an easy retirement in his home state of Louisiana. The Republican is pushing for an amendment to a major appropriations bill winding its way through Congress that would force the National Institutes of Health (NIH) to make good on a 2015 promise to move all its chimps out of research facilities. [STAT News] Editorial
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EVENTSNEW European Lung Cancer Congress (ELCC) 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – B-Cell Memory (Institut Necker-Enfants Malades) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Fellow/Research Scientist – Cancer Research (Icahn School of Medicine at Mount Sinai) Department Chair – Inflammation & Immunity (Cleveland Clinic – Lerner Research Institute) Research Associate – Innate Immune Response to Bacterial Infection (Imperial College London) Faculty Position – Aging and the Immune System (Mayo Clinic) Postdoctoral Fellow – Immunotherapy (California Institute for Biomedical Research) Postdoctoral Researcher – T Cell Biology (Washington University School of Medicine) PhD Student – Cellular Immunotherapy (Glycostem Therapeutics) Assistant, Associate, or Full Member – Cancer Immunology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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