Immune Regulation News 10.33 August 31, 2018 | |
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TOP STORYNeurons under T Cell Attack Coordinate Phagocyte-Mediated Synaptic Stripping The authors profiled the neuronal translatome in a murine model of encephalitis caused by CD8+ T cells targeting antigenic neurons. Neuronal STAT1 signaling and downstream CCL2 expression were essential for apposition of phagocytes, ensuing synaptic loss and neurological disease. [Cell] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Mixed lineage kinase domain-like (MLKL)-mRNA treatment rapidly induced T cell responses directed against tumor neo-antigens and required CD4+ and CD8+ T cells to prevent tumor growth. Type I interferon signaling and Batf3-dependent dendritic cells were essential for this mRNA treatment to elicit tumor antigen-specific T cell responses. [Nat Commun] Full Article | Press Release ZCCHC3 Is a Co-Sensor of cGAS for dsDNA Recognition in Innate Immune Response Investigators identified ZCCHC3, a CCHC-type zinc-finger protein, as a positive regulator of cytosolic double-strand (ds)DNA- and DNA virus-triggered signaling. They showed that ZCCHC3-deficiency inhibits dsDNA- and DNA virus-triggered induction of downstream effector genes, and that ZCCHC3-deficient mice are more susceptible to lethal herpes simplex virus type 1 or vaccinia virus infection. [Nat Commun] Full Article Researchers identified the nuclear receptor Nur77 as a key upstream transcriptional regulator of a pro-inflammatory metabolic switch in macrophages. [Cell Rep] Abstract | Graphical Abstract Investigators determined whether regulatory and inflammatory phenotypes of circulating CD38+ effector T cells, a population enriched for cells with mucosal antigen specificity, classify disease course in pediatric inflammatory bowel disease patients. [Mucosal Immunol] Abstract The authors evaluated the effect of alpinetin on dextran sulfate sodium-induced colitis, and elucidate the potential mechanisms. Alpinetin significantly alleviated colitis in mice, accompanied with restored Th17/Treg balance in colons. [Cell Death Dis] Full Article ADAMTS1 Protease Is Required for a Balanced Immune Cell Repertoire and Tumor Inflammatory Response Researchers performed a detailed study of the vasculature and substrates in adult organs of wild type and Adamts1-deficient mice. In addition to the expected alterations of organs like kidney, heart and aorta, they found that the lack of ADAMTS1 differently affects lymphocyte and myeloid populations in the spleen and bone marrow. [Sci Rep] Full Article Scientists hypothesized that DNA methylation is one of the molecular mechanisms driving variability in Bacillus Calmette-Guérin (BCG)-induced immune responses. DNA methylation in peripheral blood mononuclear cells from BCG vaccinated infants was measured and comparisons made between low and high BCG-specific cytokine responders. [Sci Rep] Full Article Loss of Gαq Impairs Regulatory B-Cell Function CD19+IL–10+ regulatory B-cells of wild-type and Gnaq−/− mice were analyzed by flow cytometry after stimulation by lipopolysaccharide. [Arthritis Res Ther] Full Article Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSImmunomodulation of Tumor Vessels: It Takes Two to Tango The density of intratumoral CD8+ T cells predicts patient survival and responsiveness to immunotherapy. Effector T cell infiltration in turn is controlled by the tumor vasculature which co-evolves together with an immune-suppressive environment. At the T cell-vascular interface, endothelial cells actively suppress T cell trafficking and function. [Trends Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSAffimed N.V. announced that it has entered into a strategic collaboration agreement with Genentech to develop and commercialize novel NK cell engager-based immunotherapeutics to treat multiple cancers. [Affimed N.V.] Press Release CStone’s Anti-CTLA-4 Antibody CS1002 Receives IND Approval in China CStone Pharmaceuticals announced that its IND application for CS1002, an investigational cytotoxic T-lymphocyte-associated protein-4 (CTLA-4) monoclonal antibody, has been approved by the China National Drug Administration. [CStone Pharmaceuticals (PR Newswire Association LLC.)] Press Release Genprex, Inc. announced that it has entered into amendments with The University of Texas MD Anderson Cancer Center to extend the terms of two option agreements between Genprex and MD Anderson pertaining the use of TUSC2, the active agent in Genprex’s lead product candidate Oncoprex, in combination with immunotherapies and the development and the use of biomarkers to predict patient response to TUSC2 therapy. [Genprex, Inc.] Press Release BeiGene, Ltd. announced that the National Medical Products Administration of China has accepted the new drug application for tislelizumab, an investigational anti-PD-1 antibody, as a potential treatment for patients with relapsed/refractory classical Hodgkin’s lymphoma. [BeiGene, Ltd.] Press Release Genmab A/S announced that the European Commission has granted marketing authorization for DARZALEX® in combination with bortezomib, melphalan and prednisone, for the treatment of adult patients with newly diagnosed multiple myeloma who are ineligible for autologous stem cell transplant. [Genmab A/S] Press Release | |
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POLICY NEWSClinical Trials Have Far Too Little Racial and Ethnic Diversity The symptoms of conditions such as heart disease, cancer and diabetes, as well as the contributing factors, vary across lines of ethnicity, as they do between the sexes. If diverse groups aren’t part of these studies, we can’t be sure whether the treatment will work in all populations or what side effects might emerge in one group or another. [Scientific American] Editorial Top UK Genomics Institute Investigates Bullying Allegations An investigation into allegations of bullying is under way at one of the world’s top genomics centers — the Wellcome Sanger Institute in Hinxton, UK. According to The Guardian, which first reported on the investigation at Sanger, the complaints come from current and former staff members and include allegations against the institute’s director, geneticist Michael Stratton, who has been at the helm since 2010. [Nature News] Editorial Yale Prof Gets Endowed Chair Four Years after Harassment Finding Michael Simons, a Yale School of Medicine professor who was removed from a leadership post in 2014 after the university found him guilty of sexual harassment, was given an endowed professorship in the school’s cardiology department. In response, faculty members “went into an uproar,” and the school removed an online press release about Simons’s honor, Yale Daily News reported. [The Scientist] Editorial New Research: Financial Disclosure Lacking in Publication of Clinical Trials A substantial proportion of pharmaceutical industry payments to authors of oncology clinical trials published in major scientific journals are not disclosed, new research shows. The publications focused on clinical trials that tested new cancer drugs. The new findings were published as a research letter in the journal JAMA Oncology. [OHSU] Editorial
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EVENTSNEW European Society for Medical Oncology (ESMO) 2019 Congress Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowship – Immunology (University of Nantes) Research Technologist – Cell Separation (STEMCELL Technologies Inc.) Postdoctoral Position – B-Cell Memory (Institut Necker-Enfants Malades) Postdoctoral Fellow/Research Scientist – Cancer Research (Icahn School of Medicine at Mount Sinai) Department Chair – Inflammation & Immunity (Cleveland Clinic – Lerner Research Institute) Research Associate – Innate Immune Response to Bacterial Infection (Imperial College London) Faculty Position – Aging and the Immune System (Mayo Clinic) Postdoctoral Fellow – Immunotherapy (California Institute for Biomedical Research) PhD Student – Cellular Immunotherapy (Glycostem Therapeutics) Assistant, Associate, or Full Member – Cancer Immunology (Fred Hutchinson Cancer Research Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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