Immune Regulation News 10.45 November 23, 2018 | |
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TOP STORYThe authors found that genetic inactivation of p110δ in the Eμ-TCL1 murine chronic lymphocytic leukemia model impaired B cell receptor signaling and B cell migration, and significantly delayed leukemia pathogenesis. [J Clin Invest] Full Article | |
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PUBLICATIONS(Ranked by impact factor of the journal)Researchers showed, via conditional deletion of Raptor (mTORC1) or Rictor (mTORC2), that mTORC1 and mTORC2 promote natural killer (NK) cell maturation in a cooperative and non-redundant manner, mainly by controlling the expression of Tbx21 and Eomes. [Nat Commun] Full Article Sumoylation of RORγt Regulates TH17 Differentiation and Thymocyte Development Scientists showed that the function of RORγt was regulated by its sumoylation. Loss of Sumo3, but not Sumo1, dampened TH17 differentiation and delayed the progression of thymic CD8+ immature single-positive cells. [Nat Commun] Full Article Researchers modified the oncolytic group B adenovirus enadenotucirev to express a stroma-targeted bispecific T-cell engager (BiTE). This BiTE bound fibroblast activation protein on cancer-associated fibroblasts and CD3ε on T cells, leading to potent T-cell activation and fibroblast death. [Cancer Res] Abstract | Press Release Investigators showed that pro-inflammatory macrophages were associated with fibrosis in mouse and human Duchenne muscular dystrophy (DMD) muscle. DMD-derived Ly6Cpos macrophages exhibited a profibrotic activity by sustaining fibroblast production of collagen I. [Cell Rep] Full Article | Graphical Abstract Plasminogen Activator Inhibitor-1 Promotes the Recruitment and Polarization of Macrophages in Cancer The authors demonstrated that plasminogen activator inhibitor-1 (PAI-1) promoted the recruitment and M2 polarization of monocytes/macrophages through different structural domains. Its LRP1 interacting domain regulated macrophage migration, while its C-terminal uPA interacting domain promoted M2 macrophage polarization through activation of p38MAPK and nuclear factor κB and induction of an autocrine interleukin-6/STAT3 activation pathway. [Cell Rep] Full Article | Graphical Abstract Treatment of cynomolgus monkeys with single low doses of IgG-(IL-2N88D)2 induced sustained preferential activation of Tregs accompanied by a corresponding 10–14-fold increase in CD4+ and CD8+ CD25+FOXP3+ Tregs; conditions that had no effect on CD4+ or CD8+ memory effector T cells. [J Autoimmun] Full Article Splenic CD4+ T lymphocytes from cecal ligation and puncture mice expressed gradually elevated p53 mRNA and protein levels, which resulted in extracellular regulated protein kinase 1/2 inactivation and expression of apoptotic molecules. [Cell Physiol Biochem] Full Article Investigators showed that takinib, a highly discriminatory inhibitor of transforming growth factor beta-activated kinase 1 (TAK1), selectively and potently reduced TNF production in pro-inflammatory THP-1 macrophages. [Sci Rep] Full Article Adoptive transfer of ovalbumin (OVA)-pulsed Jag1-dendritic cells to OVA-induced asthmatic mice reduced allergen-specific immunoglobulin E production, airway hyperresponsiveness, airway inflammation, and secretion of T helper type 2 (Th2)-type cytokines. [Immunology] Abstract Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSModulation of Host Immunity by Helminths: The Expanding Repertoire of Parasite Effector Molecules The authors summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery. [Immunity] Abstract Innate-Like B Cell Subsets during Immune Responses: Beyond Antibody Production B lymphocytes are recognized for their crucial role in adaptive immunity since they represent the only leukocyte lineage capable of differentiating into Ab-secreting cells. However, it has been demonstrated that these lymphocytes can exert several Ab-independent functions, including engulfing and processing Ags for presentation to T cells, secreting soluble mediators, providing co-stimulatory signals, and even participating in lymphoid tissue development. [J Leukoc Biol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSImmunocore to Co-Develop IMC-C103C, a T Cell Redirecting Bi-Specific Biologic, with Genentech Immunocore Limited announced it has entered into a new partnership with Genentech to expand an existing discovery collaboration. [Immunocore Limited] Press Release The FDA approved Gamifant for the treatment of pediatric and adult patients with primary hemophagocytic lymphohistiocytosis (HLH) who have refractory, recurrent or progressive disease or intolerance with conventional HLH therapy. [The U.S. Food and Drug Administration] Press Release | |
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POLICY NEWSAustralian Funding Delay Creates Stress and Uncertainty for Scientists A weeks-long delay in a major funding announcement is having a detrimental effect on Australian science, say researchers. [Nature News] Editorial Stop Exploitation of Foreign Postdocs in the United States A survey reveals some lab heads are using the need for visas to create unacceptable conditions for junior researchers. Some PIs are exploiting the fact that overseas scientists rely on them for continued visas. The responses suggest that senior scientists are using this reliance to force postdocs to work longer hours and endure unacceptable conditions. [Nature] Editorial To Catch Misconduct, Journals Are Hiring Research Integrity Czars Scientific journals’ creation of dedicated positions for rooting out misconduct before publication comes amid growing awareness of such issues, and stems from a recognition that spot-checking and other ad hoc arrangements were insufficient. [STAT News] Editorial
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EVENTSNEW AACR International Conference New Horizons in Cancer Research Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Natural Killer Cells (The Scripps Research Institute) Tenure-Track Assistant Professor – Cancer Immunology and Immunotherapy (University of Chicago) Faculty Positions – Translational Immunology (University of Miami) Postdoctoral Fellowship – Immune Oncology (Lund University) Postdoctoral Position – Immunology and Ion Channel Function (New York University School of Medicine) PhD Position – Cancer Immunotherapy (Helmholtz Zentrum München) Tenure/Tenure Track Faculty Position – Immunology (Wayne State University) Postdoctoral Fellow – Immunology (Johns Hopkins University) PhD Position – Antigen Presentation and Immune Regulation (Erasmus MC) Postdoctoral Fellow – Immunology (Mondor Biomedical Research Institute) Postdoctoral Fellowship – Immunology (University of Nantes) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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