Immune Regulation News 10.47 December 7, 2018 | |
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TOP STORYFBXO38 Mediates PD-1 Ubiquitination and Regulates Anti-Tumor Immunity of T Cells Scientists report a mechanism of PD-1 degradation and the importance of this mechanism in anti-tumor immunity in preclinical models. They showed that surface PD-1 undergoes internalization, subsequent ubiquitination and proteasome degradation in activated T cells. [Nature] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Commensal-Specific T Cell Plasticity Promotes Rapid Tissue Adaptation to Injury Researchers showed that skin-resident commensal-specific T cells harbor a paradoxical program characterized by a type-17 program associated with a poised type-2 state. [Science] Abstract Wiskott-Aldrich Syndrome Protein (WASP) Is a Tumor Suppressor in T Cell Lymphoma Investigators showed that the expression of WASP and WASP-interacting-protein was frequently low or absent in anaplastic large cell lymphoma compared to other T cell lymphomas. [Nat Med] Abstract Using preclinical models of full and partial MHC-mismatched hematopoietic cell transplantation, the authors showed that the granulocyte-macrophage colony-stimulating factor (GM-CSF) produced by allogeneic T cells distinguishes between the two processes. [Sci Transl Med] Abstract | Press Release Glycolipid iGb3 Feedback Amplifies Innate Immune Responses via CD1d Reverse Signaling Researchers found cluster of differentiation 1D glycoprotein (CD1d) deficiency attenuated Toll-like receptor-triggered inflammatory innate responses in macrophages and dendritic cells, protecting mice from endotoxin shock. [Cell Res] Abstract Investigators addressed the role of sirtuin-1 (Sirt-1) in graft-versus-host-disease (GvHD) induction by employing Sirt-1 conditional knock-out mice as well as a pharmacological Sirt-1 inhibitor. Using MHC-mismatched and -matched murine bone marrow transplantation models, they found that Sirt-1-/- T cells had a reduced ability to induce acute GvHD via enhanced p53 acetylation. [Blood] Abstract Scientists showed how topical antigen is acquired and presented by dendritic cells in the skin. Topical antigen was acquired by langerhans cells (LC) and CD11b+ cDC2s but not cDC1s, and both LCs and CD11b+ cDC2s reaching the lymph node could prime T cells and expand LAP+ Tregs. [Nat Commun] Full Article Induction of Immunosuppressive Functions and NF-κB by FLIP in Monocytes Investigators showed that low-dose cytotoxic chemotherapy agents caused apoptosis linked to c-FLIP down-regulation selectively in monocytes. [Nat Commun] Full Article The addition of cholesterol to a high fat diet triggered hepatic pathology reminiscent of advanced non‐alcoholic steatohepatitis (NASH) in humans characterized by signs of cholesterol dysregulation, generation of oxidized LDL, increased recruitment of hepatic macrophages, and significant fibrosis. [Hepatology] Abstract Scientists showed a previously unappreciated role for basophils at the initiation phase of emphysema formation in an elastase-induced murine model of chronic obstructive pulmonary disease (COPD) in that basophils represent less than 1% of lung-infiltrating cells. [Proc Natl Acad Sci USA] Abstract The authors showed that CD73 blockade could mediate effective purinergic reprogramming and enhance anti-tumor cytotoxicity both in vitro and in vivo by enhancing the killing ability of CAR-engineered natural killer cells against CD73+ solid tumor targets via mechanisms that might imply alleviation from adenosinergic immunometabolic suppression. [J Immunother Cancer] Full Article Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSAutophagy in the Renewal, Differentiation and Homeostasis of Immune Cells Scientists review the crucial functions of autophagy in controlling the differentiation and homeostasis of multiple immune cell types and discuss the potential mechanisms involved. [Nat Rev Immunol] Abstract Investigators summarize the current understanding of leukocyte recruitment in general and how this varies in different organs. In particular they focus on neutrophils, as these are the first circulating leukocytes to reach the site of inflammation. [Front Immunol] Full Article IL-6 and the Dysregulation of Immune, Bone, Muscle, and Metabolic Homeostasis during Spaceflight The author details what is known about the role of this key cytokine in innate and adaptive immunity, hematopoiesis, and in bone, muscle and metabolic homeostasis on Earth and in the microgravity of space and suggests an experimental approach to confirm or disavow the role of IL-6 in space-related dysregulations. [npj Microgravity] Full Article Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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SCIENCE NEWSBellicum Pharmaceuticals, Inc. announced interim results from two multicenter trials of patients treated with rivo-cel™ following a haploidentical stem cell transplant showing that rimiducid administration led to resolution of most cases of advanced Graft versus Host Disease (GvHD) or those who were refractory to standard of care treatment. [Press release from Bellicum Pharmaceuticals, Inc. discussing research presented at the 60th Annual Meeting of the American Society of Hematology (ASH), San Diego] Press Release | |
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INDUSTRY NEWSAbCellera Collaborates with Autolus on Antibody Discovery Project AbCellera announced its collaboration with Autolus Therapeutics plc. Under the partnership, AbCellera is applying its microfluidic single-cell screening platform to find novel antibodies which can be used for the development of new chimeric antigen receptor T cell therapies. [AbCellera Biologics Inc.] Press Release aTyr Pharma, Inc. announced the initiation of a Phase Ib/IIa study evaluating its lead candidate, ATYR1923, in patients with pulmonary sarcoidosis following acceptance of the company’s investigational new drug application by the FDA. [aTyr Pharma, Inc.] Press Release | |
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POLICY NEWSChina Backs Bold Plan to Tear Down Journal Paywalls In a huge boost to the open-access movement, librarians and funders in China have said that they intend to make results of publicly funded research free to read immediately on publication. The move includes a pledge of support for Plan S, a bold initiative launched in September by a group of European funders to ensure that, by 2020, their scientists make papers immediately open. [Nature News] Editorial University College London Geneticist Cleared of Wrongdoing Geneticist David Latchman, the chief academic and administrative officer of Birkbeck, University of London, had no knowledge of the image manipulation that went into several papers he coauthored, according to a second investigation by University College London, where he runs a lab. [The Scientist] Editorial
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EVENTSNEW AACR Annual Meeting 2019 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Technologist – Immunology (STEMCELL Technologies Inc.) Postdoctoral Fellow/Research Associate – Immunology (Turnstone Biologics Inc.) Postdoctoral Position – Immunology (Ludwig-Maximilians-Universität) Postdoctoral Position – Natural Killer Cells (The Scripps Research Institute) Faculty Positions – Translational Immunology (University of Miami) Postdoctoral Position – Immunology and Ion Channel Function (New York University School of Medicine) PhD Position – Cancer Immunotherapy (Helmholtz Zentrum München) Tenure/Tenure Track Faculty Position – Immunology (Wayne State University) Postdoctoral Fellowship – Immunology (University of Nantes) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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