Immune Regulation News 11.08 March 8, 2019 | |
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TOP STORYResearchers explored whether noninvasive commensal microbes may possess previously unappreciated modes of antigen acquisition or communication with the host for maintenance of mucosal T cell homeostasis. [Science] Abstract | Editorial | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Siglec-15 as an Immune Suppressor and Potential Target for Normalization Cancer Immunotherapy Investigators demonstrated that Siglec-15 suppresses antigen-specific T cell responses in vitro and in vivo. [Nat Med] Abstract | Editorial Interference with glutaminyl-peptide cyclotransferase-like protein expression led to a major increase in neutrophil-mediated killing of tumor cells in vivo. [Nat Med] Abstract SLAM Receptors Foster iNKT Cell Development by Reducing TCR Signal Strength after Positive Selection Investigators found that SLAM family receptors promoted the development of invariant natural killer T (iNKT) cells by reducing the strength of the T cell antigen receptor (TCR) signal after positive selection. [Nat Immunol] Abstract LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation The authors report that SIRT6-deficient cells and tissues accumulated abundant cytoplasmic LINE1 cDNA, which triggered strong type I interferon response via activation of cGAS. [Cell Metab] Abstract | Graphical Abstract Experimental ectopic cRel expression blocked antibody-secreting cell (ASC) differentiation by inhibiting the transcription factor Blimp1, and in wild-type cells cRel was dynamically repressed during ASC differentiation by Blimp1 binding the Rel locus. [Immunity] Abstract | Graphical Abstract CD8+ T cells expressing CD19-targeted chimeric antigen receptors persistently depleted CD19+ B cells, eliminated autoantibody production, reversed disease manifestations in target organs, and extended life spans well beyond normal in the F1 and MRLfas/fas mouse models of lupus. [Sci Transl Med] Full Article | Press Release Investigators showed that neutrophils have crucial functions in liver repair by promoting the phenotypic conversion of pro-inflammatory Ly6ChiCX3CR1lo monocytes/macrophages to pro-resolving Ly6CloCX3CR1hi macrophages. [Nat Commun] Full Article Researchers showed that IL-2R signaling was required by thymic Tregs at an early step for expansion and survival, and at a later step for functional maturation. Using inducible, conditional deletion of CD25 in peripheral Tregs, they also found that IL-2R signaling was indispensable for Treg homeostasis, whereas Treg lineage stability was largely IL-2-independent. [Nat Commun] Full Article Using a mouse model of acute lymphocytic choriomeningitis virus infection, scientists observed abundant enhancer of zeste homolog 2 (EZH2) expression and associated H3K27me3 modifications preferentially in the early committed virus-specific follicular helper T cells compared to those in T helper 1 cells. [Cell Mol Immunol] Full Article Fc gamma receptor (FcγR) genotyping of 271 healthy donors was performed using a Multiplex Ligation-Dependent Probe Amplification assay. Freeze-thawed/pre-cultured peripheral blood mononuclear cells and whole blood samples from donors were stimulated with reagents spanning different monoclonal antibody functional classes to evaluate the association of FcγR genotypes with T-cell proliferation and cytokine release. [Front Immunol] Full Article Depletion of PD-1-Positive Cells Ameliorates Autoimmune Disease Researchers showed that an immunotoxin consisting of an anti-programmed-cell-death-protein-1 (PD-1) single-chain variable fragment, an albumin-binding domain and Pseudomonas exotoxin targeting PD-1-expressing cells, selectively recognized and induced the killing of the cells. [Nat Biomed Eng] Abstract | Press Release Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSThe Evolving Role of T-Bet in Resistance to Infection The authors provide an overview of the discovery and evolutionary relationship between T-bet and eomesodermin and highlight the studies that have uncovered broader functions of T-bet in innate and adaptive immunity and in the development of the effector and memory T cell populations that mediate long-term resistance to infection. [Nat Rev Immunol] Abstract Sensing of Physiological Regulators by Innate Lymphoid Cells Maintenance of homeostasis and immune protection rely on the coordinated action of different physiological systems. Bidirectional communication between the immune system and physiological systems is required to sense and restore any disruption of equilibrium. [Cell Mol Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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SCIENCE NEWSOSE Immunotherapeutics announced that it has disclosed its novel bispecific checkpoint inhibitor platform in a plenary session. [Press release from OSE Immunotherapeutics discussing research presented at the 2019 World Immunotherapy Congress, San Diego] Press Release | |
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INDUSTRY NEWSSTEMCELL Technologies Wins Deloitte Best Managed Companies Award STEMCELL Technologies announced that the company has been selected as a winner of Canada’s Best Managed Companies program for 2019. Canada’s Best Managed Companies is the country’s leading business awards program, recognizing excellence in the management abilities and practices of Canadian owned and managed companies with revenues over $15 million. [STEMCELL Technologies Inc.] Press Release Boehringer Ingelheim and OSE Immunotherapeutics announced a collaboration and exclusive worldwide collaboration and license agreement to jointly develop OSE-172, a SIRP-alpha antagonist targeting myeloid lineage cells. [Boehringer Ingelheim] Press Release Transgene announced its decision to initiate clinical developments of its lead myvac™ candidate, TG4050, and the finalization of its collaboration agreement with NEC. [Transgene (Business Wire, Inc.)] Press Release Inovio Pharmaceuticals, Inc. announced the initiation and opening of sites to enroll the second portion of the company’s Phase III program for VGX-3100, Inovio’s DNA-based immunotherapy to treat cervical dysplasia caused by human papillomavirus (HPV). [Inovio Pharmaceuticals, Inc.] Press Release Alligator Bioscience: First Patient Dosed in Phase I study of ATOR-1015 Alligator Bioscience announced that the first patient has successfully been dosed in its Phase I study of ATOR-1015, its drug candidate in development for tumor-directed immunotherapy. [Alligator Bioscience] Press Release | |
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POLICY NEWSStudy Finds Gender Imbalances in First-Time NIH Awards Women receiving their first research grant from the National Institutes of Health are awarded an average of $39,000 less than men, according to an analysis published March 5 in JAMA. [The Scientist] Editorial Head of US Food and Drug Agency Resigns Scott Gottlieb, the head of the US Food and Drug Administration (FDA), resigned on 5 March and will depart the agency in one month. [Nature News] Editorial | Opinion
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EVENTSNEW Gordon Research Conference: Hormone-Dependent Cancers Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Faculty Position – Immunology (Fox Chase Cancer Center) NEW Research Fellow – Protective and Aberrant Immunity (Monash University) Research Technologist – Immunology (STEMCELL Technologies Inc.) Associate Scientist – Immuno-Oncology (HMH Center for Discovery & Innovation) Postdoctoral Fellow – Tumor Immunology (University of Maryland) Postdoctoral Fellow – Tumor Immune Evasion (Luxembourg Institute of Health) Staff Scientist – Immunology (Cellzome GmbH) Postdoctoral Fellow – Cancer Checkpoint Immunotherapy (City of Hope) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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