Immune Regulation News 11.23 June 28, 2019 | |
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TOP STORYMicrobiota Therapy Acts via a Regulatory T Cell MyD88/RORγt Pathway to Suppress Food Allergy Bacteriotherapy induced expression by Treg cells of the transcription factor ROR-γt in a MyD88-dependent manner, which was deficient in food allergy infants and mice and ineffectively induced by their microbiota. [Nat Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Lipid-Associated Macrophages Control Metabolic Homeostasis in a Trem2-Dependent Manner Scientists describe a novel and conserved Trem2+ lipid-associated macrophage subset and identify markers, spatial localization, origin, and functional pathways associated with these cells. [Cell] Abstract | Graphical Abstract Researchers found that LC3-associated endocytosis in microglia was a critical regulator of immune-mediated aggregate removal and microglial activation in a murine model of Alzheimer’s disease. [Cell] Abstract | Press Release Epstein-Barr-Virus-Induced One-Carbon Metabolism Drives B Cell Transformation Epstein-Barr virus (EBV)-encoded EBNA2 and its target MYC were required for upregulation of the central mitochondrial one-carbon enzyme MTHFD2, which played key roles in EBV-driven B cell growth and survival. [Cell Metab] Full Article | Graphical Abstract TREM2 Function Impedes Tau Seeding in Neuritic Plaques The authors showed that germline knockout of triggering receptor expressed on myeloid cells 2 (Trem2) or the TREM2R47H variant reduced microgliosis around amyloid-β plaques and facilitated the seeding and spreading of neuritic plaque tau aggregates. [Nat Neurosci] Abstract | Editorial Brain-Resident Memory T Cells Generated Early in Life Predispose to Autoimmune Disease in Mice Investigators report that transient viral infection of the brain in early life, but not at a later age, precipitated brain autoimmune disease elicited by adoptive transfer of myelin-specific CD4+ T cells at sites of previous infection in adult mice. [Sci Transl Med] Abstract | Press Release Researchers report that STING knockout mice were as resistant to murine cytomegalovirus infection as wild-type controls, whereas mice with a combined Toll-like receptor/RIG-I-like receptor/STING signaling deficiency did not mount type 1 interferon responses and succumb to the infection. [Nat Commun] Full Article Scientists identified two major phases of thymic epithelial cell (TEC) loss during aging: a block in mature TEC differentiation from the pool of immature precursors, occurring at the onset of puberty, followed by impaired bipotent TEC progenitor differentiation and depletion of Sca-1lo cTEC and mTEC lineage-specific precursors. [Cell Rep] Full Article | Graphical Abstract The authors demonstrated that NETosis is an important neutrophil function that promoted breast cancer liver metastasis. Immature low-density neutrophils relied on the catabolism of glutamate and proline to support mitochondrial-dependent metabolism in the absence of glucose, which enabled sustained NETosis. [Cell Rep] Full Article | Graphical Abstract BANK1 Interacts with TRAF6 and MyD88 in Innate Immune Signaling in B Cells Investigators revealed by coimmunoprecipitation analyses the binding of BANK1 with TRAF6 and MyD88, which were mediated by the BANK1 Toll/interleukin-1 receptor domain. [Cell Mol Immunol] Full Article Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSMicrobial Genes and Pathways in Inflammatory Bowel Disease The authors highlight current knowledge of gut microbial factors linked to inflammatory bowel disease (IBD) pathogenesis and discuss how multiomics data from large-scale population studies in health and disease have been used to identify specific microbial strains, transcriptional changes and metabolic alterations associated with IBD. [Nat Rev Microbiol] Abstract Tissue-Resident Memory T Cells in Cancer Immunosurveillance Scientists discuss the emerging role of tissue-resident CD8+ memory T (TRM) cells in anticancer immunity. They highlight defining features of tumor-localizing TRM cells, examine the mechanisms through which they have recently been shown to suppress cancer growth, and explore their potential as future targets of cancer immunotherapy. [Trends Immunol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSIntensity Therapeutics Announces Clinical Collaboration with Merck Intensity Therapeutics, Inc. announced that it has entered into an agreement with Merck through a subsidiary, to evaluate the combination of Intensity’s lead product candidate INT230-6 and KEYTRUDA®, Merck’s anti-programmed death receptor-1 therapy, in patients with advanced solid malignancies including pancreatic, bile duct, squamous cell and non-MSI high colon cancers. [Intensity Therapeutics, Inc.] Press Release The Lupus Research Alliance and its affiliate, Lupus Therapeutics, announced that it has broadened its collaboration with Bristol-Myers Squibb (BMS) to assess the investigational drug BMS-986165 as a potential new therapy for lupus nephritis. [Lupus Research Alliance] Press Release SpringWorks Therapeutics, Inc. announced that the company has entered into a clinical trial collaboration agreement with GlaxoSmithKline to evaluate SpringWorks Therapeutics’ investigational gamma secretase inhibitor, nirogacestat, in combination with GlaxoSmithKline’s investigational anti-B-cell maturation antigen antibody-drug conjugate, belantamab mafodotin, in patients with relapsed or refractory multiple myeloma. [SpringWorks Therapeutics, Inc.] Press Release AbbVie to Acquire Allergan for $63 Billion in Megamerger of Pharma Giants AbbVie said it will acquire Allergan for $63 billion — the latest megamerger between two pharma giants seeking new ways to grow. [STAT News] Press Release TILT Biotherapeutics Ltd announced that it has entered into an agreement with Merck KGaA, Darmstadt, Germany and Pfizer to evaluate its armed oncolytic virus, TILT-123, with avelumab in patients with solid tumors refractory to routine modalities. [TILT Biotherapeutics Ltd (Business Wire, Inc.)] Press Release Inovio Pharmaceuticals, Inc. announced the completion of target enrollment of 198 participants for its pivotal Phase III registration trial of VGX-3100, a novel DNA-based immunotherapy being tested to treat cervical dysplasia caused by human papillomavirus (HPV). [Inovio Pharmaceuticals, Inc.] Press Release X4 Pharmaceuticals, Inc. announced the initiation of 4WHIM, a pivotal Phase III global clinical trial of mavorixafor for the treatment of WHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome, a rare, inherited, primary immunodeficiency disease. [X4 Pharmaceuticals, Inc.] Press Release ImmusanT Discontinues Phase II Clinical Trial for Nexvax2® in Patients with Celiac Disease ImmusanT, Inc. has discontinued the Phase II global study for its lead candidate, Nexvax2®, intended as a treatment for celiac disease. [ImmusanT, Inc.] Press Release The FDA approved Soliris injection for intravenous use for the treatment of neuromyelitis optica spectrum disorder in adult patients who are anti-aquaporin-4 antibody positive. [The US Food and Drug Administration] Press Release | |
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POLICY NEWSDiscrimination Drives LGBT+ Scientists to Think About Quitting Nearly one-third of physical scientists from sexual and gender minorities in the United Kingdom have considered leaving their jobs because of their workplace climate, suggests a survey. And 18% who are lesbian, gay, bisexual, transgender or from other sexual and gender minorities (LGBT+) said they had experienced harassment, bullying or exclusionary behavior in the workplace. [Nature News] Editorial Proposal to Close UK Mouse-Research Center Is ‘Major Threat’ Leaders and senior scientists at a national mouse-genetics center in the United Kingdom have written an open letter decrying a recommendation to close the facility’s on-site academic research unit. The closure of the MRC Harwell Institute’s Mammalian Genetics Unit – where scientists study disease using animal models – would be “a major threat to mouse genetics in the UK”, says the letter, organized by 14 senior Harwell scientists. [Nature News] Editorial
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JOB OPPORTUNITIESNEW Postdoctoral Research Scientist – Molecular Immunology (Babraham Institute) PhD Scholarships – Systems Biology in Immune and Infectious Diseases (University of Perugia) Postdoctoral Position – Immunology (KU Leuven) Postdoctoral Position – Genetics & Immunology (Columbia University Medical Center) Postdoctoral Position – Cancer Immunology (Feinberg School of Medicine-Northwestern University) Postdoctoral Fellow – Intracellular Innate Immunity (EPFL) Postdoctoral Fellow – Transplantation Immunology (Medical College of Wisconsin) Postdoctoral Position – Immunology of Enteric Infections (University of Utah) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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