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Pulmonary Cell News| Immune Regulation News 11.25 July 12, 2019 | |
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TOP STORYProgrammable Bacteria Induce Durable Tumor Regression and Systemic Antitumor Immunity Scientists showed that delivery of nanobody antagonist of CD47 by tumor-colonizing bacteria increased activation of tumor-infiltrating T cells, stimulated rapid tumor regression, prevented metastasis and led to long-term survival in a syngeneic tumor model in mice. [Nat Med] Abstract | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)Connecting Blood and Intratumoral Treg Cell Activity in Predicting Future Relapse in Breast Cancer The signaling responsiveness of peripheral blood Treg II cells to immunosuppressive, T helper type 1 and T helper type 2 cytokines reflected intratumoral immunosuppressive potential, and predicted future relapse in two independent cohorts of patients with breast cancer. [Nat Immunol] Abstract | Press Release Plasma Cells Are Obligate Effectors of Enhanced Myelopoiesis in Aging Bone Marrow Researchers examined the contribution of plasma cells (PCs) to age-related increases in myelopoiesis, as PCs exhibited immune regulatory function and sequester in bone marrow. [Immunity] Abstract | Graphical Abstract The authors describe a de novo autoimmune mouse model of anti-N-methyl-D-aspartate (NMDA) receptor encephalitis. Active immunization of immunocompetent mice with conformationally stabilized, native-like NMDA receptors induced a fulminant encephalitis, consistent with the behavioral and pathologic characteristics of human cases. [Sci Transl Med] Abstract | Press Release Investigators showed reduction of fetal thymic size, altered thymic architecture and reduced fetal thymic regulatory T cell output in preeclamptic pregnancies, which persists up to four years of age in human offspring. [Nat Commun] Full Article | Press Release Scientists report in an animal model of neonatal rats that hypoxic-ischemic encephalopathy significantly upregulated miR-210 expression in microglia in the neonatal brain and strongly induced activated microglia. [Cell Mol Immunol] Abstract JunB Plays a Crucial Role in Development of Regulatory T Cells by Promoting IL-2 Signaling Researchers showed that mice lacking JunB in CD4+ T cells were more susceptible to dextran sulfate sodium-induced colitis because of impaired development of regulatory T cells. [Mucosal Immunol] Full Article | Editorial IRF1 Is Critical for the TNF-Driven Interferon Response in Rheumatoid Fibroblast-Like Synoviocytes The authors showed that TNF regulated the expression of the transcription factor interferon regulatory factor 1 (IRF1) in human fibroblast-like synoviocytes as well as in a TNF transgenic arthritis mouse model. [Exp Mol Med] Full Article Investigators examined the role of KLF2, a zinc-finger transcription factor that regulates immune cell activation, in specifying myeloid cell functions during muscle regeneration. Loss of KLF2 in myeloid lineage cells dramatically enhanced the initial inflammatory response to acute muscle injury. [iScience] Abstract | Graphical Abstract | Full Article Scientists specifically deleted Von Hippel-Landau protein (VHL) in B cells using CD19-Cre and demonstrated that metabolic balance was essential for naïve B cell survival. Loss of VHL disturbed glycolytic and oxidative metabolic balance and caused severe reduction in mature B cells. [iScience] Abstract | Graphical Abstract | Full Article Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWST Follicular Helper Cells and T Follicular Regulatory Cells in Rheumatic Diseases T follicular helper (TFH) cells are instrumental in supporting antibody affinity maturation in germinal center reactions and humoral memory formation, whereas T follicular regulatory cells suppress TFH cell-mediated antibody responses. [Nat Rev Rheumatol] Abstract Staphylococcus epidermidis Role in the Skin Microenvironment Recently, by using state‐of‐the‐art technologies, it was revealed that the cutaneous microbiota interact with skin immune cells. Strikingly, commensal S. epidermidis‐induced CD8+ T cells induce re‐epithelization of the skin after injury, accelerating wound closure. [J Cell Mol Med] Full Article Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSMacroGenics, Inc. and I-Mab Biopharma announced that the companies have entered into an exclusive collaboration and license agreement to develop and commercialize enoblituzumab. [MacroGenics, Inc.] Press Release Be The Match BioTherapies® and Tmunity Therapeutics, Inc. announced a partnership to accelerate patient access to life-saving cell therapies. [Be The Match BioTherapies®] Press Release Nimbus Therapeutics and Celgene Expand Alliance to Immunotherapy in Oncology Nimbus Therapeutics announced the expansion of its long-term strategic alliance with Celgene Corporation to include Nimbus’ HPK1 inhibitor program. [Nimbus Therapeutics] Press Release HOOKIPA Pharma Inc. announced that its Investigational New Drug (IND) Application for a Phase I/II clinical trial of HB-201 for the treatment of Human Papilloma Virus (HPV)-positive cancers is now effective following the clearance by the FDA. [HOOKIPA Pharma Inc.] Press Release Compass Therapeutics Announces First Patient Dosed in Phase I Trial of CTX-471 Compass Therapeutics announced the first patient has been dosed in its multi-center, open-label, first-in-human Phase I trial of CTX-471, a fully human monoclonal antibody that binds and activates a unique epitope of the co-stimulatory receptor CD137 expressed on T cells and NK cells. [Compass Therapeutics] Press Release Transgene announced it has received the approval from the UK Medicines and Healthcare Products Regulatory Agency (MHRA) to proceed with a Phase I clinical trial of its lead myvac™ candidate TG4050. [Transgene] Press Release Geneos Therapeutics announced that the first cancer patient was dosed using the company’s GT-EPIC Neoantigen-Targeting Personalized Vaccine Technology. [Geneos Therapeutics (PR Newswire Association LLC)] Press Release | |
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POLICY NEWSResearchers in the University of California system lost subscription access to the major publisher Elsevier, the result of a closely watched fight between the two parties over how academic research should get read and paid for. [STAT News] Editorial As Visa Difficulties Persist, Scientists Push for Change Individual researchers and science societies are finding solutions so colleagues around the globe can attend conferences, from remote presentations to relocating conferences. [The Scientist] Editorial
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EVENTSNEW 3rd Annual Meeting of the Upper Rhine Immunology Group Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Research Associate – Immune Cell Culture (STEMCELL Technologies Inc.) Postdoctoral Position – Mucosal Immunology (University of California San Diego) Postdoctoral Research Scientist – Molecular Immunology (Babraham Institute) PhD Scholarships – Systems Biology in Immune and Infectious Diseases (University of Perugia) Postdoctoral Position – Genetics & Immunology (Columbia University Medical Center) Postdoctoral Position – Cancer Immunology (Feinberg School of Medicine-Northwestern University) Postdoctoral Position – Immunology of Enteric Infections (University of Utah) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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