Immune Regulation News 11.33 September 6, 2019 | |
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TOP STORYMicrobial Metabolites Control the Thymic Development of Mucosal-Associated Invariant T Cells Scientists showed that commensal bacteria govern murine mucosal-associated invariant T (MAIT) intrathymic development, as MAIT cells did not recirculate to the thymus. MAIT development required RibD expression in bacteria, indicating that production of the MAIT antigen 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil was necessary. [Science] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer Researchers developed a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient’s lifetime. [Cell Stem Cell] Abstract | Graphical Abstract A follicular regulatory T (TFR) cell-deleter mouse was developed that selectively deletes TFR cells, facilitating temporal studies. TFR cells were found to regulate early, but not late, germinal center responses to control antigen-specific antibody and B cell memory. [Nat Immunol] Abstract Overcoming Adaptive Therapy Resistance in AML by Targeting Immune Response Pathways The authors identified activation of innate immune stress response pathways after treatment of FMS-like receptor tyrosine kinase (FLT3)-mutant acute myeloid leukemia (AML) cells with FLT3 inhibitors and showed that innate immune pathway activation via the interleukin-1 receptor-associated kinase 1 and 4 complex contributes to adaptive resistance in FLT3-mutant AML cells. [Sci Transl Med] Abstract CD3 Bispecific Antibody-Induced Cytokine Release Is Dispensable for Cytotoxic T Cell Activity Investigators report the cell type-specific cellular mechanisms that link CD3 bispecific antibody-mediated killing to toxic cytokine release. The immunologic cascade was initiated by T cell triggering, whereas monocytes and macrophages were the primary source of systemic toxic cytokine release. [Sci Transl Med] Abstract Using Alzheimer’s disease (AD) mouse models, scientists discovered that, during AD progression, the alteration of gut microbiota composition led to the peripheral accumulation of phenylalanine and isoleucine, which stimulated the differentiation and proliferation of pro-inflammatory T helper 1 cells. [Cell Res] Full Article Sustained Type I Interferon Signaling as a Mechanism of Resistance to PD-1 Blockade Researchers identified the deleterious role of signaling via the type I interferon receptor in tumor and antigen presenting cells, that induced the expression of nitric oxide synthase 2, associated with intratumor accumulation of regulatory T cells and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody. [Cell Res] Full Article Protein Prenylation Restrains Innate Immunity by Inhibiting Rac1 Effector Interactions The authors showed that heterozygous deletion of the Rho family gene Rac1, but not Rhoa and Cdc42, reversed inflammation and arthritis in geranylgeranyltransferase type I-deficient mice. [Nat Commun] Full Article Alpha B-crystallin (CRYAB) was found to be significantly decreased in the inflamed mucosa from inflammatory bowel disease patients and dextran sulfate sodium-induced colitis in mice, and negatively correlated with the levels of TNF-α and IL-6, respectively. [Mucosal Immunol] Full Article Investigators report that targeting diacylglycerol (DAG) kinase zeta, a negative regulator of DAG-mediated cell signaling, protected against allergic asthma by simultaneously reducing airway inflammation and airway hyperresponsiveness though independent mechanisms. [Sci Signal] Full Article Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSTranslating Gammadelta (γδ) T Cells and Their Receptors into Cancer Cell Therapies Researchers discuss the challenges and opportunities for the clinical implementation of cancer immunotherapies based on γδT cells and their receptors. [Nat Rev Drug Discov] Abstract Immune Regulation of Metabolic Homeostasis by Helminths and Their Molecules The authors discuss how helminths, which are among the strongest natural inducers of type 2 immunity, and some of their unique immunomodulatory molecules, may contribute to the maintenance of tissue-specific and whole-body metabolic homeostasis and protection against obesity-associated meta-inflammation. [Trends Parasitol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSIdera Pharmaceuticals Announces Immuno-Oncology Clinical Research Collaboration with AbbVie Idera Pharmaceuticals, Inc. announced that they have entered into an immuno-oncology clinical research collaboration with AbbVie. [Idera Pharmaceuticals, Inc.] Press Release IFM Therapeutics announced that IFM Due has reached a collaboration and exclusive option agreement with Novartis to develop a suite of immunotherapies that inhibit the cGAS/STING pathway to treat a range of serious inflammatory and autoimmune diseases. [IFM Therapeutics, LLC] Press Release Infinity Pharmaceuticals, Inc. announced the initiation of two clinical trials for IPI-549, a first-in-class, oral immuno-oncology product candidate targeting immune-suppressive tumor-associated myeloid cells through selective inhibition of phosphoinositide-3-kinase-gamma. [Infinity Pharmaceuticals, Inc.] Press Release ZyVersa Therapeutics Advances Development of Lead Inflammasome Inhibitor Candidate, IC 100 ZyVersa Therapeutics, Inc. announced significant advancements in development of their lead inflammasome inhibitor candidate, IC 100. [ZyVersa Therapeutics, Inc.] Press Release Ribon Therapeutics announced the dosing of the first patient in its Phase I clinical trial of RBN-2397, the company’s first-in-class PARP7 inhibitor. [Ribon Therapeutics] Press Release BioLineRx Ltd. announced that it has successfully completed the dose-escalation part of the Phase I/IIa clinical study for AGI-134, a novel compound that evokes a direct anti-tumor response, as well as a vaccine effect, via a unique, multi-arm mechanism that targets patient-specific tumor neoantigens. [BioLineRx Ltd.] Press Release OSE Immunotherapeutics announced the grant of a new patent from the European Patent Office strengthening the protection covering OSE-703, a humanized monoclonal antibody directed against the extracellular domain of the alpha-chain of the receptor for interleukin-7 (CD127) making it cytotoxic for human cells expressing CD127, and its use thereof in immuno-oncology treatment. [OSE Immunotherapeutics] Press Release | |
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POLICY NEWSWorld Health Organization Backs Open-Access Plan S The World Health Organization is joining cOAlition S, a growing group of agencies and charities that fund scientific research and that require their grantees to share their work in open-access journals or repositories. [The Scientist] Editorial A new White House directive laying out next year’s spending priorities for federal research agencies describes a US science enterprise imperiled by internal problems and foreign governments. [ScienceInsider] Editorial UK Science Minister Jo Johnson Resigns Amid Brexit Drama UK science minister Jo Johnson has resigned from his position as universities and science minister and as a member of the House of Commons, citing conflicts between what he thinks is best for the country and family ties. [Nature News] Editorial
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EVENTSNEW Precision Health: Molecular Basis, Technology and Digital Health Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Position – Interface of Stem Cell Biology and Immunology (Columbia University) Research Technologist (STEMCELL Technologies Inc.) Scientific Communications Coordinator (STEMCELL Technologies Inc.) Scientist – Human Immunology (STEMCELL Technologies Inc.) Research Associate – Immune Cell Culture (STEMCELL Technologies Inc.) Faculty Position – Tumor Immunology (University of Utah) Assistant Professor and Postdoctoral Fellows – Immunology (Chinese Academy of Sciences) Laboratory Manager – Human Immunology (Karolinska Institutet) Professorship – Innate Immunity and Cardiovascular Repair (Goethe University Frankfurt am Main) Staff Scientist – Lead Immunotherapy Bioinformatician (Fred Hutchinson Cancer Research Center) Assistant Professor – Neuro-Immune/Neuro-Pharmacological Interactions (University of Pennsylvania) Postdoctoral Fellow – Quantitative Microscopy of Immune Cells (National Institute on Aging) Postdoctoral Position – Immunology of Enteric Infections (University of Utah) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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