Immune Regulation News 11.35 September 20, 2019 | |
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TOP STORYScientists showed that, while inflammation initially damaged olfactory neurons and activated horizontal basal stem cells (HBC)-mediated regeneration, continued inflammation locked HBCs in an undifferentiated state. [Cell Stem Cell] Abstract | Press Release | Graphical Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)SDHA Gain-of-Function Engages Inflammatory Mitochondrial Retrograde Signaling via KEAP1-Nrf2 SDHA gain-of-function led to an accumulation of fumarate in persistent polyclonal B cell lymphocytosis B cells, which engaged the KEAP1-Nrf2 system to drive the transcription of genes encoding inflammatory cytokines. [Nat Immunol] Abstract MHC class II was expressed on intestinal epithelial cells (IECs) within the ileum at steady state but was absent from the IECs of germ-free mice. IEC-specific deletion of MHC class II prevented the initiation of lethal graft-versus-host disease in the gastrointestinal tract. [Immunity] Abstract | Graphical Abstract Double Negative T Cells Mediate Lag3-Dependent Antigen-Specific Protection in Allergic Asthma The immunosuppressive function of the ovalbumin-specific double negative T cells was dependent on the inhibition of CD11b+ dendritic cell function, T follicular helper cell proliferation, and IL-21 production. [Nat Commun] Full Article Receptor-interacting protein kinase (Ripk)1K376R/- mice were viable but developed severe systemic inflammation that was mainly driven by RIPK3-dependent signaling pathway, indicating that K63-linked ubiquitination on Lys376 residue of RIPK1 also contributed to inflammation process. [Nat Commun] Full Article Investigators report that the sympathetic nervous system limited the generation of pathogenic T cells and disease development in an experimental autoimmune encephalomyelitis model of multiple sclerosis. [Cell Rep] Full Article | Graphical Abstract The authors showed that mesenchymal stromal cells from smoldering multiple myeloma patients activated neutrophils and conferred an immunosuppressive and pro-angiogenic phenotype. [Cell Death Dis] Full Article Researchers determined whether non-thermal plasma suppressed mast cell activation, which was important for allergic response, and ameliorated an atopic dermatitis-like skin inflammatory disease in mice. [Sci Rep] Full Article Animals given SYN0012 had improved cardiac function, as measured by echocardiogram, reduced tissue remodeling, and altered transcription of inflammatory and proangiogenic genes. [JCI Insight] Full Article | Press Release Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSNext-Generation Regulatory T Cell Therapy The authors describe the key advances and prospects in designing and implementing Treg cell-based therapy in autoimmunity and transplantation. [Nat Rev Drug Discov] Abstract The Heterogeneous Pathogenesis of Type 1 Diabetes Mellitus The latest developments in understanding the heterogeneity of type 1 diabetes mellitus and characterization of major disease subtypes might help in the development of preventive treatments. [Nat Rev Endocrinol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSXBiotech Announces Granting of Canadian Patent for Treatment of Dermatological Pathologies XBiotech Inc. announced that the Canadian Patent Office has granted XBiotech a patent covering the use of bermekimab in the treatment of inflammatory skin diseases. The patent describes studies showing that antibodies which specifically neutralize the activity of interleukin-1alpha, such as bermekimab, reduce skin inflammation and treat inflammatory skin diseases. [XBiotech, Inc.] Press Release FUJIFILM and Australian Company Have Exclusive Contracts for Regenerative Medical Products FUJIFILM Co., Ltd. announced that it has signed a license agreement with Cynata Therapeutics in Australia. Cynata is conducting clinical trials for products for bone marrow transplant complications. FUJIFILM invested about 8% in Cynata and had the right to sign a license agreement for a product for the complication “graft versus host disease”. [Cynata Therapeutics] Press Release | |
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POLICY NEWSKashmir’s Communication Blackout Is a ‘Devastating Blow’ for Academics, Researchers Say Six professors from India’s top science institutions have appealed to the government to lift the blockade of academic and research institutions in Indian-controlled Kashmir. The blockade has been a “devastating blow,” the six write in an open letter published September 18th. [ScienceMagazine] Editorial Senate Bill Would Give NIH $3 Billion in 2020, or 7.7% Boost A Senate spending panel today released a draft 2020 spending bill containing a hefty $3 billion increase for the National Institutes of Health (NIH) that would bring the agency’s total budget to $42.1 billion. That 7.7% boost is $1 billion more than a House of Representatives committee approved in its version of the bill in April, and would amount to a 40% increase in NIH’s budget over the past five years. [ScienceMagazine] Editorial
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EVENTSNEW NF-kB, JAK-STAT & MAPK in Health, Disease & Therapy Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Chief – Laboratory of Allergic Diseases (National Institute of Allergy and Infectious Diseases) Research Technologist (STEMCELL Technologies Inc.) Scientist – Human Immunology (STEMCELL Technologies Inc.) Research Associate – Immune Cell Culture (STEMCELL Technologies Inc.) Postdoctoral Fellow – Cancer Immunology (University of Alabama at Birmingham) Postdoctoral Position – Interface of Stem Cell Biology and Immunology (Columbia University) Faculty Position – Tumor Immunology (University of Utah) Assistant Professor and Postdoctoral Fellows – Immunology (Chinese Academy of Sciences) Staff Scientist – Lead Immunotherapy Bioinformatician (Fred Hutchinson Cancer Research Center) Assistant Professor – Neuro-Immune/Neuro-Pharmacological Interactions (University of Pennsylvania) Postdoctoral Fellow – Quantitative Microscopy of Immune Cells (National Institute on Aging) Postdoctoral Position – Immunology of Enteric Infections (University of Utah) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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