Immune Regulation News Volume 11.37 | Oct 4 2019

TOP STORY

An Allosteric Anti-Tryptase Antibody for the Treatment of Mast Cell-Mediated Severe Asthma

Scientists showed that mast cell tryptase was elevated in severe asthma patients independent of type 2 biomarker status. Active β-tryptase allele count correlated with blood tryptase levels, and asthma patients carrying more active alleles benefited less from anti-IgE treatment. [Cell] Abstract | Graphical Abstract

(Ranked by impact factor of the journal)

Liver-Derived Signals Sequentially Reprogram Myeloid Enhancers to Initiate and Maintain Kupffer Cell Identity

Researchers characterized transcriptomic and epigenetic changes in repopulating liver macrophages following acute Kupffer cell depletion as a means to infer signaling pathways and transcription factors that promoted Kupffer cell differentiation. [Immunity] Abstract | Graphical Abstract

Antibody-Mediated Targeting of TNFR2 Activates CD8⁺ T Cells in Mice and Promotes Antitumor Immunity

The authors showed that new murine monoclonal anti-tumor necrosis factor receptor 2 (TNFR2) antibodies yielded robust antitumor activity and durable protective memory in multiple mouse cancer cell line models. [Sci Transl Med] Abstract

Recent BCR Stimulation Induces a Negative Autoregulatory Loop via FBXO10 Mediated Degradation of HGAL

Investigators demonstrated that B-cell receptor (BCR) stimulation induced rapid and reversible palmitoylation of the SCF-FBXO10 ubiquitin E3 ligase. This resulted in FBXO10 relocation to the cell membrane, where it targeted the human germinal center-associated lymphoma (HGAL) protein for ubiquitylation and degradation, leading to decreases in both BCR-induced calcium influx and phosphorylation of proximal BCR effectors. [Leukemia] Abstract

Type I Interferon Delivery by iPSC-Derived Myeloid Cells Elicits Antitumor Immunity via XCR1⁺ Dendritic Cells

Scientists generated interferon (IFN)-α-producing cells by genetically engineering induced pluripotent stem cell (iPSC)-derived proliferating myeloid cells (iPSC-pMCs). Local administration of IFN-α-producing iPSC-pMCs altered the tumor microenvironment and propagated the molecular signature associated with type I IFN. [Cell Rep] Full Article | Graphical Abstract

Fine Tuning of the DNAM-1/TIGIT/Ligand Axis in Mucosal T Cells and Its Dysregulation in Pediatric Inflammatory Bowel Diseases (IBD)

Researchers showed that DNAM-1 and TIGIT displayed a peculiar expression pattern on gut mucosa T-cell populations, in a microenvironment where their shared ligands are physiologically present. [Mucosal Immunol] Abstract

Colitis Susceptibility in Mice with Reactive Oxygen Species Deficiency Is Mediated by Mucus Barrier and Immune Defense Defects

The authors assessed if a hypomorphic patient-relevant chronic granulomatous disease mutation would increase the risk for intestinal inflammation in mice. Cyba mutant mice generated low intestinal reactive oxygen species, while maintaining Nox4 function. [Mucosal Immunol] Abstract

LncRNA SNHG14/miR-5590-3p/ZEB1 Positive Feedback Loop Promoted Diffuse Large B Cell Lymphoma Progression and Immune Evasion through Regulating PD-1/PD-L1 Checkpoint

Mechanistically, small nucleolar RNA host gene 14 (SNHG14) sponged miR-5590-3p to upregulate Zinc finger E-box binding homeobox 1 (ZEB1), and ZEB1 transcriptionally activated SNHG14 and programmed death ligand 1 (PD-L1) to promote the immune evasion of diffuse large B cell lymphoma cells. [Cell Death Dis] Full Article

HCV p7 as a Novel Vaccine-Target Inducing Multifunctional CD4⁺ and CD8⁺ T-Cells Targeting Liver Cells Expressing the Viral Antigen

Investigators demonstrated that hepatitis C virus (HCV) p7 derived from genotype 1a and 1b sequences were highly immunogenic in mice when employed as overlapping peptides formulated as nanoparticles with the cross-priming adjuvant, CAF09. [Sci Rep] Full Article

IL-12 Signaling Drives the Differentiation and Function of a T_H1-Derived T_FH1-Like Cell Population

Scientists describe a population of murine T helper 1 (T_H1)-derived, T follicular helper 1 (T_FH1)-like cells that express the chemokine receptor Cxcr3 and produce both the T_H1 cytokine interferon-γ and the T_FH-associated cytokine interleukin (IL)-21. [Sci Rep] Full Article

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The Role of Innate Immunity in Asthma Development and Protection: Lessons from the Environment

The dual role played by innate immunity in asthma pathogenesis offers multiple opportunities for both research and clinical interventions and is the subject of this review. [Clin Exp Allergy] Abstract

Visit our reviews page to see a complete list of reviews in the immune regulation research field.

Ra Pharmaceuticals Announces Dosing of First Patient in Global Phase III Pivotal Study of Zilucoplan for gMG

Ra Pharmaceuticals, Inc. announced the initiation of dosing in the RAISE study, its global, pivotal, Phase III clinical trial evaluating zilucoplan for the treatment of generalized myasthenia gravis (gMG). [Ra Pharmaceuticals, Inc.] Press Release

Bavarian Nordic Completes Enrollment of Phase II Trial in Chordoma Patients

Bavarian Nordic A/S announced the completion of enrollment of the Phase II trial investigating the novel targeted cancer immunotherapy candidate BN-Brachyury, in the treatment of advanced chordoma. [Bavarian Nordic A/S] Press Release

AnaptysBio Reports Positive Topline Data from Interim Analysis of GALLOP Phase II Clinical Trial of ANB019 Monotherapy in Moderate-to-Severe Generalized Pustular Psoriasis

AnaptysBio, Inc. announced positive topline data from an interim analysis of its Phase II clinical trial of ANB019 in moderate-to-severe generalized pustular psoriasis patients, also known as the GALLOP trial. [AnaptysBio, Inc.] Press Release

Annexon Biosciences Reports Top-Line Phase Ib Results for Novel C1q Inhibitor ANX005 in Guillain-Barré Syndrome

Annexon Biosciences announced encouraging results from a Phase Ib dose-ranging clinical trial to evaluate its anti-C1q antibody, ANX005. [Annexon Biosciences (Business Wire, Inc.)] Press Release

Kalytera Announces Notice of Allowance of EU Patent for Prevention and Treatment of Graft versus Host Disease

Kalytera Therapeutics, Inc. announced that the European Patent Office has issued a Notice of Allowance for EU Patent Application Number 14791611.8 covering the use of cannabidiol in the treatment of graft versus host disease. [Kalytera Therapeutics, Inc.] Press Release

BlueWillow Awarded NIH Contract to Advance Development of Its Therapeutic Peanut Allergy Vaccine

BlueWillow Biologics^® announced it has been awarded a Fast-Track Small Business Research Innovation contract from the National Institute of Allergy and Infectious Diseases for the development of an intranasal therapeutic peanut allergy vaccine using the company’s NanoVax^® platform. [BlueWillow Biologics^®] Press Release

‘More Women Are Being Nominated’: Nobel Academy Head Discusses Diversity

The Royal Swedish Academy of Sciences introduced measures that it hoped would tackle the issue by encouraging scientists to put forward a more diverse range of nominees. These included asking more women to suggest candidates, and altering the wording of the letter inviting nominations. [Nature News] Editorial

Split Decisions: How Brexit Has Taken a Toll on Five Researchers

On 23 June 2016, 34 million UK citizens took to the polls to vote on a simple, fateful question: Should the United Kingdom remain a part of the European Union, or should it leave? Nearly 52%—a majority of 1.3 million—wanted out, and conservative politicians vowed to carry out the people’s wishes. [ScienceInsider] Editorial

NEW 14^th World Immune Regulation Meeting (WIRM)
March 4-7, 2020
Davos, Switzerland

Visit our events page to see a complete list of events in the community.

NEW Postdoctoral Fellow – Immunology and Vaccines (University of Maryland)

Research Technologist (STEMCELL Technologies Inc.)

Scientist – Human Immunology (STEMCELL Technologies Inc.)

Research Associate – Immune Cell Culture (STEMCELL Technologies Inc.)

Postdoctoral Research Associate – Innate Immune Signaling Pathways and Mechanisms (University of Utah)

Chief – Laboratory of Allergic Diseases (National Institute of Allergy and Infectious Diseases)

Postdoctoral Fellow – Cancer Immunology (University of Alabama at Birmingham)

Postdoctoral Position – Interface of Stem Cell Biology and Immunology (Columbia University)

Faculty Position – Tumor Immunology (University of Utah)

Assistant Professor and Postdoctoral Fellows – Immunology (Chinese Academy of Sciences)

Assistant Professor – Neuro-Immune/Neuro-Pharmacological Interactions (University of Pennsylvania)

Associate or Full Professor – Neuro-Immune/Neuro-Pharmacological Interactions (University of Pennsylvania)

Postdoctoral Position – Immunology of Enteric Infections (University of Utah)

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