Immune Regulation News 12.15 May 1, 2020 | |
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TOP STORYBrain Control of Humoral Immune Responses Amenable to Behavioral Modulation Investigators showed that splenic denervation in mice specifically compromised the formation of plasma cells during a T cell-dependent but not T cell-independent immune response. [Nature] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)CRISPR Screen in Regulatory T Cells Reveals Modulators of Foxp3 Researchers developed a CRISPR-based pooled screening platform for phenotypes in primary mouse Treg cells and applied this technology to perform a targeted loss-of-function screen of around 500 nuclear factors to identify gene regulatory programs that promote or disrupt Foxp3 expression. [Nature] Abstract The authors validated intrathecal delivery of EPHA2, HER2 and interleukin 13 receptor α2 chimeric antigen receptor T cells as an effective treatment for primary, metastatic and recurrent group 3 medulloblastoma and posterior fossa group A ependymoma xenografts in mouse models. [Nat Med] Abstract Tumor Microenvironment Remodeling Enables Bypass of Oncogenic KRAS Dependency in Pancreatic Cancer Scientists explored mechanisms involving the tumor microenvironment as a potential basis for resistance to targeting KRAS*. Using the inducible KrasG12D p53 null PDAC mouse model, gain-of-function screens of epigenetic regulators identified HDAC5 as the top hit enabling KRAS* independent tumor growth. [Cancer Discov] Abstract The authors examined the anatomic distribution, clonal relationships, and functional properties of T-bet+ and T-bet− memory B cells in the context of the influenza-specific immune response. In mice, both T-bet− and T-bet+ hemagglutinin-specific B cells arose in germinal centers, acquired memory B cell markers, and persisted indefinitely. [Immunity] Abstract | Graphical Abstract Tissue-Resident Ductal Macrophages Survey the Mammary Epithelium and Facilitate Tissue Remodeling Researchers identified a unique population of tissue-resident ductal macrophages that formed a contiguous network between the luminal and basal layers of the epithelial tree throughout postnatal development. [Nat Cell Biol] Abstract Engineered Niches Support the Development of Human Dendritic Cells in Humanized Mice Engraftment of engineered mesenchymal stromal cells together with CD34+ hematopoietic stem and progenitor cells created an in vivo synthetic niche in the dermis of immunodeficient mice driving the differentiation of classical dendritic cells (DCs) and CD123+AXL+CD327+ pre/AS-DCs. [Nat Commun] Full Article NOD2 Modulates Immune Tolerance via the GM-CSF-Dependent Generation of CD103+ Dendritic Cells Scientists demonstrated that intraperitoneal administration of muramyl dipeptide triggered regulatory T cells and the accumulation of a population of tolerogenic CD103+ dendritic cells in the spleen. [Proc Natl Acad Sci USA] Abstract Researchers used methyl-β-cyclodextrin to load mouse peritoneal macrophages with [13C]cholesterol. They then plated the macrophages onto smooth muscle cells that had been metabolically labeled with [15N]choline. [Proc Natl Acad Sci USA] Abstract Investigators developed FS222, a bispecific tetravalent antibody targeting CD137 and PD-L1 to induce T cell activation to eradicate tumors without the current toxicity and efficacy limitations seen clinically. [Clin Cancer Res] Abstract Investigators report that T-cell-specific targeting of the enzyme acetyl-CoA carboxylase 1, a major checkpoint controlling fatty acid synthesis, impaired intestinal Th1 and Th17 responses by limiting CD4+ T-cell expansion and infiltration into the lamina propria in murine models of colitis and infection-associated intestinal inflammation. [Mucosal Immunol] Abstract IL-33/ST2/IL-9/IL-9R Signaling Disrupts Ocular Surface Barrier in Allergic Inflammation Two murine models of experimental allergic conjunctivitis and IL-9 topical challenge in wild type Balb/c and ST2−/− mice, and two culture models of primarily human corneal epithelial cells and mouse CD4+ T cells were performed. [Mucosal Immunol] Abstract Subscribe to our sister publications: Human Immunology News & Immunology of Infectious Disease News. | |
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REVIEWSThe authors broadly discuss the role of immune cell subpopulation and the involved cytokines and chemokines during cardiac repair post-myocardial infraction, particular in cardiac inflammation and fibrosis. [J Cell Physiol] Abstract Visit our reviews page to see a complete list of reviews in the immune regulation research field. | |
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INDUSTRY NEWSSanofi and Regeneron Pharmaceuticals, Inc. announced the primary endpoint of overall survival was met in a Phase III trial comparing the PD-1 inhibitor Libtayo® to platinum doublet chemotherapy in patients with first-line locally advanced or metastatic non-small cell lung cancer that tested positive for PD-L1 in ≥50% of tumor cells. [Sanofi] Press Release Akari Therapeutics, Plc announced that it achieved the primary and secondary endpoints for nomacopan in its fully recruited Phase II trial in bullous pemphigoid and is planning to discuss Phase III pivotal study designs with the FDA and EMA. [Akari Therapeutics, Plc] Press Release | |
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POLICY NEWSStudents Stand Up for Sub-Contracted Workers amid COVID-19 Crisis Students at a number of universities have been advocating for the payment of employees, and especially contracted workers who are more vulnerable to layoffs, as campuses shut down during the COVID-19 pandemic. [The Scientist] Editorial The Pandemic’s Effects on Recruiting International STEM Trainees Pandemic-related concerns that have arisen for science trainees-shuttered labs, research and education delays, anxiety-are applicable across the board. But international graduate students and postdocs face a suite of unique challenges that raise uncertainty about recruiting and supporting this critical group of researchers in the future. [The Scientist] Editorial As COVID-19 Forces Conferences Online, Scientists Discover Upsides of Virtual Format As the novel coronavirus outbreak shutters businesses and disrupts everyday life for billions around the globe, massive annual conferences and small society meetings alike have moved online. The new format poses numerous technical and organizational challenges, but it also offers opportunities- for reaching wider audiences, reducing the carbon footprint of meeting travel, and improving diversity and equity. [ScienceInsider] Editorial
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EVENTSIn light of COVID-19, many conferences are being cancelled or postponed. As such: We are suspending new event postings in our newsletters and on Twitter. Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Postdoctoral Fellowships – Autoimmune Conditions (Benaroya Research Institute at Virginia Mason) NEW Postdoctoral Associate – Immunology and Mitochondrial Biology (Texas A&M Health Science Center) NEW Principle Scientist – Immunology and Gene Engineering (Empyrean Therapeutics Ltd) Postdoctoral Researcher – Immune Checkpoint Therapy (Canadian Nuclear Laboratories) Postdoctoral Researcher – Cancer Treatment Sensitivty (Johannes Kepler University of Linz) Chair – Department of Microbiology and Immunology (Western University) Postdoctoral Fellow – Acute Myeloid Leukemia (Icahn School of Medicine at Mount Sinai) Principle Scientist – Cancer and Auto-Immune Disorders (Sanofi) Postdoctoral Fellow – Mucosal Immunology and Allergies (University of Michigan) Postdoctoral Fellow – Leukemia Biology and Dendritic Cells (Dana Farber Cancer Institute) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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