 | | Vol. 12.22 – 19 June, 2020 |
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| Investigators tested the therapeutic concept that chimeric antigen receptor (CAR) T cells that target senescent cells could be effective senolytic agents. They identified the urokinase-type plasminogen activator receptor (uPAR)11 as a cell-surface protein that is broadly induced during senescence and showed that uPAR-specific CAR T cells efficiently ablated senescent cells in vitro and in vivo.
[Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors suggested that urea cycle hyperreactivity and excessive polyamine generation in psoriatic keratinocytes promoted self-RNA sensation and highlighted protein phosphatase 6 deregulation in keratinocytes as a pivotal event that amplified the inflammatory circuits in psoriasis.
[Immunity] |
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| Researchers examined the transcriptomic profile of adipose-resident eosinophils and posit that KLF3 regulates adipose tissue function via transcriptional control of secreted molecules linked to beiging.
[Nature Communications] |
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| Investigators found that human and mouse macrophages underwent a switch to glycolysis in response to IgG immune complex stimulation, mirroring macrophage metabolic changes in inflamed tissue in vivo. This metabolic reprogramming was required to generate a number of proinflammatory mediators, including IL-1β, and was dependent on mTOR and hypoxia-inducible factor-1α.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers investigated the impact of acute local allergen exposure on the frequency and phenotype of tissue eosinophils within remote mucosal organs.
[Mucosal Immunology] |
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| Scientists explored how using a synthetic cell-penetrating peptide mimic for intracellular anti-protein kinase C theta delivery fine-tuned differentiation of induced regulatory T cells, through its differential effects on RNA processing.
[Molecular Therapy] |
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| To explore the role of the spleen and splenic macrophages, key players in the cholinergic anti-inflammatory pathway, splenectomy, and adoptive transfer of macrophages treated with the selective α7 nicotinic acetylcholine receptor agonist GTS-21 were conducted.
[Scientific Reports] |
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| Using a syngeneic hepatoceullar carcinoma (HCC) mouse model, the authors demonstrated that treatment with apatinib resulted in attenuation of tumor growth and increased tumor vessel normalization. Results indicated that NK cells, but not CD4+ or CD8+ T cells mediated the therapeutic efficacy of apatinib in HCC mouse models.
[Cancer Gene Therapy] |
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| Scientists combined intratumoral administration of the synthetic toll-like receptor 4 agonist glucopyranosyl lipid A with either active vaccination or adoptive transfer of tumor-specific CD8 T cells to mice bearing established melanomas.
[Npj Vaccines] |
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| Researchers assessed expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis, including in extra-articular, subcutaneous rheumatoid nodules.
[Genes and Immunity] |
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| The authors review recent findings within this context and discuss the technological advances that are revolutionizing the study of macrophage biology.
[Immunity] |
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| Investigators explore current strategies that shift immune cell metabolism to pro-inflammatory states in the tumor microenvironment and highlight a need to better replicate physiologic conditions to select targets, clarify mechanisms, and optimize metabolic inhibitors.
[Molecular Cell] |
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| Scientists discuss the potential of anti-neurogenesis and, considering the interplay between nervous and immune systems, they also focus on anti-immunosuppression-based therapies.
[Signal Transduction and Targeted Therapy] |
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| A bipartisan group of US senators proposed sweeping—and controversial—changes in how the federal government manages academic research in the face of threats from other countries.
[ScienceInsider] |
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| Principia Biopharma, Inc. announced positive data on durability of response from an ongoing Phase I/II trial of its investigational treatment, rilzabrutinib.
[Principia Biopharma, Inc.] |
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| 2020-07-16 – 2020-07-17
Virtual |
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| | Lund University – Lund, Sweden |
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| | King’s College London – London, United Kingdom |
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| | Lund University – Scania, Sweden |
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| | Aarhus University – Aarhus C, Denmark |
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| | Howard Hughes Medical Institute – Durham, North Carolina, United States |
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| | Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States |
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| | University of Southern Denmark – Odense M, Denmark |
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| | Benaroya Research Institute at Virginia Mason – Seattle, Washington, United States |
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| | Texas A&M Health Science Center – College Station, Texas, United States |
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| | Empyrean Therapeutics Ltd – Cambridge, United Kingdom |
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| | Sanofi – La Jolla, California, United States |
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