 | | Vol. 12.24 – 3 July, 2020 |
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| To advance our understanding of immunology outside the hematopoietic system, researchers systematically investigate the regulation of immune genes in the three major types of structural cells: epithelium, endothelium and fibroblasts.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that the chromatin remodeler Chd4, also called Mi-2β, played a key role in the self-antigen expression in medullary thymic epithelial cells.
[Nature Immunology] |
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| The authors showed that Rab44 was highly expressed in bone marrow cells among various mouse tissues.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers established an apoptosis inhibitor of macrophage (AIM)-deficient IgAN model using CRISPR/Cas9 and compared its phenotype with that of wild-type gddY with or without recombinant AIM administration. An IgA-deficient IgAN model was also generated to further determine the role of AIM.
[Journal of the American Society of Nephrology] |
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| Investigators elucidated the relative importance of these distinct biological functions of MCL-1 in T regulatory cells to assess whether MCL-1 inhibition might impact upon the metabolism of cells able to resist apoptosis.
[Cell Death & Differentiation] |
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| Researchers report that exosomes from bone marrow-derived cells in tumor-bearing mice, but not in healthy mice, carried PD-L1. PD-L1 on these exosomes was biofunctional and could inhibit CD8+ T cell proliferation and activation in vitro and in vivo.
[Cellular & Molecular Immunology] |
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| Investigators performed RNA sequencing on circulating neutrophils from healthy adult females and males. Female neutrophils displayed significant up-regulation of type I IFN-stimulated genes.
[Scientific Reports] |
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| The authors showed that lipopolysaccharide (LPS) stimulation of RAW264.7 murine macrophage celled results in pyroptosis when cells were cultured in high glucose medium.
[Scientific Reports] |
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| Mechanistically, several immune receptors, adapter proteins, ubiquitin ligases, and transcription factors formed complex signal transduction networks to control ACOD1 expression in a context-dependent manner.
[Cellular & Molecular Immunology] |
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| The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
[ScienceInsider] |
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| Academics in Hong Kong are facing new worries after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
[ScienceInsider] |
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| Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist] |
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| October 20 – October 21
Virtual |
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| | University of Luxembourg – Luxembourg, Luxembourg |
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| | Lund University – Lund, Sweden |
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| | King’s College London – London, United Kingdom |
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| | Lund University – Scania, Sweden |
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| | Aarhus University – Aarhus C, Denmark |
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