 | | Vol. 12.25 – 10 July, 2020 |
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| Investigators used single-cell transcriptomics to profile 32,000 synovial tissue macrophages and identified phenotypic changes in patients with early/active rheumatoid arthritis (RA), treatment-refractory/active RA and RA in sustained remission.
[Nature Medicine] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| The authors showed that adipose tissue eosinophils underwent major age-related changes in distribution and function associated with impaired adipose tissue homeostasis and systemic low-grade inflammation in both humans and mice.
[Nature Metabolism] |
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| Scientists demonstrated that provision of OX40L by dendritic cells, but not T cells, B cells nor group 3 innate lymphoid cells, was critical specifically for the effector Th1 response to an acute systemic infection with Listeria monocytogenes.
[Nature Communications] |
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| Researchers demonstrated that the induction of a regulatory program in human B cells was dependent on a metabolic priming event driven by cholesterol metabolism.
[Nature Communications] |
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| The authors found that early inhibition of miR-21 in naive T cells impaired IL-17 producing CD4+ T cell (Th17) differentiation in vitro and abrogated Th17-mediated multiple myeloma cell proliferation and osteoclasts activity.
[Leukemia] |
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| Using a strain of congenic SAMP mice engineered to lack global expression of ERβ, investigators observed dramatic, female-specific exacerbation of intestinal inflammation accompanied by significant reductions in intestinal regulatory T cell frequency and function.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors report that the expression of CXCL5 was elevated in tumor tissues and positively associated with lymphatic metastasis and tumor differentiation.
[Oncogenesis] |
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| The lungs of AhR−/− mice showed increased presence Th17 cells concomitant with reduced numbers of Th1, Th22 and Foxp3+ Treg cells.
[Scientific Reports] |
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| The authors showed that Rab44 was highly expressed in bone marrow cells among various mouse tissues.
[Scientific Reports] |
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| Through the successes of checkpoint blockade and adoptive cellular therapy, immunotherapy has become an established treatment modality for cancer.
[Nature Reviews Cancer] |
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| Scientists outline pathways for the major cell death programs and their potential roles in chronic inflammation. They also discuss current and developing therapies that target the cell death machinery.
[Nature Reviews Rheumatology] |
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| Scientists discuss the diversity of functional interactions between T cells and ILCs during homeostasis and immune responses.
[Mucosal Immunology] |
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| Ziopharm Oncology, Inc. announced the initiation of a Phase I clinical trial to evaluate CD19-specific CAR-T, using its Rapid Personalized Manufacturing technology, as an investigational treatment for patients with relapsed CD19+ leukemias and lymphomas.
[ZIOPHARM Oncology Inc.] |
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| Zymeworks Inc. announced that it and longtime partner, Merck have signed a new license agreement granting Merck the right to develop additional multispecific antibody therapeutic candidates using Zymeworks’ Azymetric™ and EFECT™ platforms.
[Zymeworks Inc.] |
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| International students completing their medical and doctoral degrees in the US are wrestling with frustration and uncertainty following the release of federal rules this week that could bar them from staying in the country.
[STAT] |
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| October 20 – October 21
Virtual |
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| | West Virginia University – Morgantown, West Virginia, United States |
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| | University of Luxembourg – Luxembourg, Luxembourg |
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| | Lund University – Lund, Sweden |
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| | Lund University – Scania, Sweden |
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| | Aarhus University – Aarhus C, Denmark |
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