| Vol. 12.26 – 17 July, 2020 |
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| Researchers performed bulk RNA sequencing of 17 organs and plasma proteomics at ten ages across the lifespan of Mus musculus, and integrated these findings with data from the accompanying Tabula Muris Senis—or ‘Mouse Ageing Cell Atlas’—which followed on from the original Tabula Muris. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that myocardial infarction accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans. [Nature Medicine] |
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| Investigators report that mice with a CD8+ T cell–restricted neuropilin-1 deletion exhibited substantially enhanced protection from tumor rechallenge and sensitivity to anti-PD1 immunotherapy, despite unchanged primary tumor growth. [Nature Immunology] |
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| Scientists showed that persistent antigenic stimulation impaired ADP-coupled oxidative phosphorylation. [Nature Immunology] |
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| The authors performed a genome-wide CRISPR loss-of-function screen to identify Foxp3 regulators in mouse primary T regulatory cells. Foxp3 regulators were enriched in genes encoding subunits of the SWI/SNF nucleosome-remodeling and SAGA chromatin-modifying complexes. [Immunity] |
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| Investigators demonstrated that while PRDM15 was largely dispensable for mouse adult somatic cell homeostasis in vivo, it played a critical role in B-cell lymphomagenesis. [Nature Communications] |
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| Using a transgenic steroidogenesis-reporter mouse line the authors identified and characterized de novo steroidogenic immune cells, defining the global gene expression identity of these steroid-producing immune cells and gene regulatory networks by using single-cell transcriptomics. [Nature Communications] |
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| Scientists found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to diabetes-associated periodontitis. [Cellular & Molecular Immunology] |
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| Researchers found that under homeostatic conditions the nuclear receptor liver X receptor, a sensor of cholesterol metabolites, regulated RORγt+ CD4 T cells in the intestine draining mesenteric lymph node. [Mucosal Immunology] |
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| 5-aminolevulinic acid-mediated sonodynamic therapy inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells and collagen but increased elastin by day 28. [Scientific Reports] |
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| Histones were rapidly lethal to neutrophils after binding to cells, but formation of fibrinogen/fibrin-histone aggregates prevented cell death. [Scientific Reports] |
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| Investigators present emerging data regarding eosinophils as predictive biomarkers and effector cells in immunotherapy, especially in response to immune checkpoint blockade therapy, and highlight outstanding questions for future basic and clinical cancer research. [Nature Reviews Cancer] |
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| Results from BCG vaccination studies in humans showed that trained immunity might at least partly account for the heterologous beneficial effects of BCG vaccination. [Nature Reviews Urology] |
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| AC Immune SA announced the initiation of the second highest dosing group in the company’s Phase Ib/IIa clinical trial evaluating ACI-35.030 for the treatment of Alzheimer’s disease. [AC Immune] |
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| Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing. [Nature News] |
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| Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences. [Science Insider] |
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| October 20 – October 21 Virtual |
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| Institute of Parasitology and Biomedicine Lopez-Neyra – Granada, Spain |
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| West Virginia University – Morgantown, West Virginia, United States |
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| University of Luxembourg – Luxembourg, Luxembourg |
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| Lund University – Lund, Sweden |
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| Lund University – Scania, Sweden |
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