Immune Regulation News Volume 12.26 | Jul 17 2020

    0
    64







    IRN 12.26 | July 17


    Immune Regulation News by STEMCELL Technologies
    Vol. 12.26 – 17 July, 2020
    TOP STORY

    Aging Hallmarks Exhibit Organ-Specific Temporal Signatures

    Researchers performed bulk RNA sequencing of 17 organs and plasma proteomics at ten ages across the lifespan of Mus musculus, and integrated these findings with data from the accompanying Tabula Muris Senis—or ‘Mouse Ageing Cell Atlas’—which followed on from the original Tabula Muris.
    [Nature]

    Abstract
    Use ImmunoCultâ„¢ to differentiate mouse CD4+ cells to Tregs.
    PUBLICATIONSRanked by the impact factor of the journal

    Myocardial Infarction Accelerates Breast Cancer via Innate Immune Reprogramming

    Scientists showed that myocardial infarction accelerates breast cancer outgrowth and cancer-specific mortality in mice and humans.
    [Nature Medicine]

    Abstract

    Neuropilin-1 Is a T Cell Memory Checkpoint Limiting Long-Term Antitumor Immunity

    Investigators report that mice with a CD8+ T cell–restricted neuropilin-1 deletion exhibited substantially enhanced protection from tumor rechallenge and sensitivity to anti-PD1 immunotherapy, despite unchanged primary tumor growth.
    [Nature Immunology]

    Abstract

    Impaired Mitochondrial Oxidative Phosphorylation Limits the Self-Renewal of T Cells Exposed to Persistent Antigen

    Scientists showed that persistent antigenic stimulation impaired ADP-coupled oxidative phosphorylation.
    [Nature Immunology]

    Abstract

    A Genome-Wide CRISPR Screen Reveals a Role for the Non-Canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function

    The authors performed a genome-wide CRISPR loss-of-function screen to identify Foxp3 regulators in mouse primary T regulatory cells. Foxp3 regulators were enriched in genes encoding subunits of the SWI/SNF nucleosome-remodeling and SAGA chromatin-modifying complexes.
    [Immunity]

    AbstractFull ArticlePress Release
    Graphical Abstract

    PRDM15 Is a Key Regulator of Metabolism Critical to Sustain B-Cell Lymphomagenesis

    Investigators demonstrated that while PRDM15 was largely dispensable for mouse adult somatic cell homeostasis in vivo, it played a critical role in B-cell lymphomagenesis.
    [Nature Communications]

    Full Article

    Tumors Induce De Novo Steroid Biosynthesis in T Cells to Evade Immunity

    Using a transgenic steroidogenesis-reporter mouse line the authors identified and characterized de novo steroidogenic immune cells, defining the global gene expression identity of these steroid-producing immune cells and gene regulatory networks by using single-cell transcriptomics.
    [Nature Communications]

    Full Article

    Inhibition of CCL2 by Bindarit Alleviates Diabetes-Associated Periodontitis by Suppressing Inflammatory Monocyte Infiltration and Altering Macrophage Properties

    Scientists found that persistently elevated CCL2 levels in combination with proinflammatory monocyte infiltration of periodontal tissues were closely related to diabetes-associated periodontitis.
    [Cellular & Molecular Immunology]

    Full Article

    Liver X Receptor Regulates Th17 and RORγt+ Treg Cells by Distinct Mechanisms

    Researchers found that under homeostatic conditions the nuclear receptor liver X receptor, a sensor of cholesterol metabolites, regulated RORγt+ CD4 T cells in the intestine draining mesenteric lymph node.
    [Mucosal Immunology]

    Abstract

    Early Modulation of Macrophage ROS-PPARγ-NF-κB Signaling by Sonodynamic Therapy Attenuates Neointimal Hyperplasia in Rabbits

    5-aminolevulinic acid-mediated sonodynamic therapy inhibited neointima formation without affecting re-endothelialization, increased blood perfusion, decreased the content of macrophages, proliferating smooth muscle cells and collagen but increased elastin by day 28.
    [Scientific Reports]

    Full Article

    Fibrinogen Protects Neutrophils from the Cytotoxic Effects of Histones and Delays Neutrophil Extracellular Trap Formation Induced by Ionomycin

    Histones were rapidly lethal to neutrophils after binding to cells, but formation of fibrinogen/fibrin-histone aggregates prevented cell death.
    [Scientific Reports]

    Full Article

    Virtual Conference Exhibition: Immunology
    REVIEWS

    A New Dawn for Eosinophils in the Tumor Microenvironment

    Investigators present emerging data regarding eosinophils as predictive biomarkers and effector cells in immunotherapy, especially in response to immune checkpoint blockade therapy, and highlight outstanding questions for future basic and clinical cancer research.
    [Nature Reviews Cancer]

    Abstract

    Trained Immunity as a Molecular Mechanism for BCG Immunotherapy in Bladder Cancer

    Results from BCG vaccination studies in humans showed that trained immunity might at least partly account for the heterologous beneficial effects of BCG vaccination.
    [Nature Reviews Urology]

    Abstract

    INDUSTRY AND POLICY NEWS

    AC Immune Advances phospho-Tau Alzheimer’s Vaccine in Phase Ib/IIa Study

    AC Immune SA announced the initiation of the second highest dosing group in the company’s Phase Ib/IIa clinical trial evaluating ACI-35.030 for the treatment of Alzheimer’s disease.
    [AC Immune]

    Press Release

    Open-Access Plan S to Allow Publishing in Any Journal

    Funding agencies behind the radical open-access initiative Plan S have announced a policy that could make it possible for researchers to bypass journals’ restrictions on open publishing.
    [Nature News]

    Editorial

    During the Pandemic, Students Do Field and Lab Work without Leaving Home

    Some researchers worry students will miss out on certain practical and problem-solving skills and won’t be able to judge whether the hands-on work of a scientist is a good fit for them. But instructors are developing high-tech ways to simulate the field and lab experiences.
    [Science Insider]

    Editorial

    FEATURED EVENT

    The New York Stem Cell Foundation (NYSCF) Conference

    October 20 – October 21
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Group Leader – Immune-Based Disorders and Infectious Diseases

    Institute of Parasitology and Biomedicine Lopez-Neyra – Granada, Spain

    Postdoctoral Positions – Cancer Epigenomics

    West Virginia University – Morgantown, West Virginia, United States

    Postdoctoral Researcher – Microbiome in Chronic Diseases

    University of Luxembourg – Luxembourg, Luxembourg

    Postdoctoral Researcher – RNA Epitranscriptomics and Immune Cells

    Lund University – Lund, Sweden

    Professor – Immunology

    Lund University – Scania, Sweden

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Immune Regulation News Twitter