 | | Vol. 12.27 – 24 July, 2020 |
| |
|
|
| The authors used a combination of imaging, single cell, and surgical approaches to identify a CD69+ CD4 T cell population in both the mouse and human brain, distinct from circulating CD4 T cells.
[Cell] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Investigators report the transcriptional profiling of 11,868 cells in a mouse model of transplant arteriosclerosis by single-cell RNA sequencing.
[Circulation Research] |
|
|
|
| Researchers created a mouse model mimicking human esophageal squamous cell carcinoma (ESCC) development and construct a single-cell ESCC developmental atlas.
[Nature Communications] |
|
|
|
| Cytokine secretion from HCT116 cells and cellular migration were attenuated by inhibiting F. nucleatum host-cell binding and entry using galactose sugars, L-arginine, neutralizing membrane protein antibodies, or fap2 deletion. F. nucleatum also induced the mobilization of immune cells in the tumor microenvironment.
[Science Signaling] |
|
|
|
| Scientists investigated the roles of programmed death-1 (PD-1) inhibitor, one of the widespread used immune checkpoint inhibitors, in the development of murine cardiac injury.
[Cell Death & Disease] |
|
|
|
| The knockdown of the hematopoietic cell–specific transcription factors PU.1 and IRF4 decreased PD-L2 expression in GM-CSF-induced mouse bone marrow–derived dendritic cells.
[Journal of Immunology] |
|
|
|
| Scientists investigated for the first time the consequences of HDAC11 genetic impairment on skeletal muscle regeneration, a process principally dependent on its resident stem cells in coordination with infiltrating immune cells and stromal cells.
[FEBS Journal] |
|
|
|
| Investigators evaluated the inflammatory cell population in the adipose tissue of MRL/lpr mice, which could potentially influence their lean phenotype. They compared beige fat activity between the MRL/MpJ and MRL/lpr mice.
[Scientific Reports] |
|
|
|
| To further evaluate the role of UBASH3A in type 1 diabetes, scientists targeted Ubash3a in NOD mice using zinc-finger nuclease mediated mutagenesis.
[Scientific Reports] |
|
|
|
| Researchers showed that pretreatment with sarsasapogenin significantly inhibited acute adipose tissue inflammatory responses in LPS-treated mice.
[Acta Pharmacologica Sinica] |
|
|
|
| The authors investigated the role of soluble T-cell immunoglobulin domain and mucin domain-containing molecule-3 in inhibition of release of inflammatory mediators.
[Cell Death Discovery] |
|
|
|
| Investigators assessed the role of glycolysis in the T cell-dependent immune response using T cell-specific Pgam1-deficient mice. Both CD8 and CD4 T cell-dependent immune responses were attenuated by Pgam1 deficiency.
[Communications Biology] |
|  |
|
|
|
| The authors surmise that neutrophils can provide tools to tailor current immunotherapy strategies and pave the way to myeloid cell-centred therapeutic strategies, which would be complementary to current approaches.
[Nature Reviews Cancer] |
|
|
|
| In addition to the T cell receptor, γδ T cells usually express activating natural killer (NK) receptors, such as NKp30, NKp44, or NKG2D which binds to stress-inducible surface molecules that are absent on healthy cells but are frequently expressed on malignant cells.
[Cellular & Molecular Immunology] |
|
|
|
|
| Talaris Therapeutics, Inc. announced that the first patient has been dosed in the FREEDOM-1 Phase III clinical trial of FCR001 in living donor kidney transplant recipients.
[Talaris Therapeutics, Inc.] |
|
|
|
| Aurinia Pharmaceuticals, Inc. announced that the FDA has accepted the filing of its New Drug Application for voclosporin, as a potential treatment for lupus nephritis, a serious inflammation of the kidneys caused by the autoimmune disease systemic lupus erythematosus.
[Aurinia Pharmaceuticals, Inc.] |
|
|
|
| The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider] |
|
|
|
| Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist] |
|
|
|
| For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
[ScienceInsider] |
|
|
|
|
| September 10 – September 11
Virtual |
|
|
|
|
|
| | University of Dundee – Dundee, United Kingdom |
|
|
|
| | Institute of Parasitology and Biomedicine Lopez-Neyra – Granada, Spain |
|
|
|
| | West Virginia University – Morgantown, West Virginia, United States |
|
|
|
| | University of Luxembourg – Luxembourg, Luxembourg |
|
|
|
| | Lund University – Lund, Sweden |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
