Immune Regulation News Volume 12.27 | Jul 31 2020

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    IRN 12.27 | July 31


    Immune Regulation News by STEMCELL Technologies
    Vol. 12.27 – 31 July, 2020
    TOP STORY

    Distinct and Temporary-Restricted Epigenetic Mechanisms Regulate Human αβ and γδ T Cell Development

    Scientists employed RNA-sequencing, ATAC–sequencing and ChIPmentation on well-defined thymocyte subsets that represented the continuum of human T cell development.
    [Nature Immunology]

    Abstract
    Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.
    PUBLICATIONSRanked by the impact factor of the journal

    Single-Cell Transcriptome Profiling Reveals Neutrophil Heterogeneity in Homeostasis and Infection

    Scientists profiled >25,000 differentiating and mature mouse neutrophils using single-cell RNA sequencing to provide a comprehensive transcriptional landscape of neutrophil maturation, function and fate decision in their steady state and during bacterial infection.
    [Nature Immunology]

    Abstract

    Transcriptome Profiling Identifies TIGIT as a Marker of T Cell Exhaustion in Liver Cancer

    Investigators performed for the first time a comprehensive mRNA profiling of CD8 T cells in a murine model of autochthonous liver cancer by comparing the transcriptome of naive, functional effector and exhausted, tumor‐specific CD8 T cells.
    [Hepatology]

    Full Article

    Histone Deacetylase 3 Controls Lung Alveolar Macrophage Development and Homeostasis

    Researchers showed that histone deacetylase 3 was a key epigenetic factor required for avelolar macrophage embryonic development, postnatal homeostasis, maturation, and regeneration from bone marrow.
    [Nature Communications]

    Full Article

    Hydroxychloroquine in Rheumatic Autoimmune Disorders and Beyond

    By influencing several cellular pathways through different mechanisms, chloroquine and hydroxychloroquine inhibited multiple endolysosomal functions, including autophagy, as well as endosomal Toll‐like receptor activation and calcium signaling.
    [EMBO Molecular Medicine]

    Full Article

    Regulatory T Cells Suppress Th17 Cell Ca2+ Signaling in the Spinal Cord during Murine Autoimmune Neuroinflammation

    Investigators used two-photon microscopy to elucidate the spatial organization, motility characteristics, and interactions of endogenous Treg and Th17 cells together with antigen-presenting cells within the spinal cord leptomeninges in experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

    Specific Targeting of Ovarian Tumor-Associated Macrophages by Large, Anionic Nanoparticles

    Researchers showed that relatively large anionic nanoparticles administered intraperitoneally selectively accumulated in tumor-associated macrophages.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    PTPN2 Deficiency Enhances Programmed T Cell Expansion and Survival Capacity of Activated T Cells

    Scientists found that PTPN2 deficiency renders cells in vivo and in vitro less dependent on survival-promoting cytokines, such as interleukin (IL)-2 and IL-15.
    [Cell Reports]

    Full ArticleGraphical Abstract

    An Apoptotic Caspase Network Safeguards Cell Death Induction in Pyroptotic Macrophages

    The authors showed that independently of GSDMD-mediated plasma membrane permeabilization, inflammasome receptors engaged caspase-1 and caspase-8, both of which redundantly promoted activation of apoptotic executioner caspase-3 and caspase-7 in pyroptotic macrophages.
    [Cell Reports]

    AbstractGraphical Abstract

    The Soluble Glycoprotein NMB (GPNMB) Produced by Macrophages Induces Cancer Stemness and Metastasis via CD44 and IL-33

    Using mouse tumor models, investigators showed that macrophage-derived soluble GPNMB increased tumor growth and metastasis in Gpnmb-mutant mice.
    [Cellular & Molecular Immunology]

    Abstract

    Regulatory Role of Gpr84 in the Switch of Alveolar Macrophages from CD11blo to CD11bhi Status during Lung Injury Process

    In LPS-induced acute lung injury mouse model, researchers identified the internal LPS-induced switch of aveolar macrophages from CD11blo to more inflamed CD11bhi status, which is deeply related to the exacerbated imbalance of homeostasis in the lung injury process.
    [Mucosal Immunology]

    Abstract

    Microbiota-Dependent Expansion of Testicular IL-17-Producing Vγ6+ γδ T Cells upon Puberty Promotes Local Tissue Immune Surveillance

    Investigators characterized a population of interleukin 17-producing γδ T cells that seeded the testis of naive C57BL/6 mice, expand at puberty and persisted throughout adulthood.
    [Mucosal Immunology]

    Full Article

    Spatiotemporal PET Imaging Reveals Differences in CAR-T Tumor Retention in Triple-Negative Breast Cancer Models

    Researchers generated and characterized traceable CAR T cells and examined potential negative effects of radionuclide reporter use. They applied the platform to two different triple-negative breast cancer models and unexpectedly observed pronounced differences in CAR-T tumor retention by PET/computed tomography and confirmed data ex vivo.
    [Molecular Therapy]

    Full ArticleGraphical Abstract

    Stay current with COVID-19 research. Read Immunology of Infectious Disease News now.
    REVIEWS

    Single-Cell Approaches to Investigate B Cells and Antibodies in Autoimmune Neurological Disorders

    High-resolution single-cell methods have revealed abnormalities in the tolerance mechanisms of several disorders and provided further insight into the B cells responsible for autoantibody production
    [Cellular & Molecular Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Emerald Health Pharmaceuticals Begins Enrollment in Phase IIa Study of EHP-101 for the Treatment of Systemic Sclerosis

    Emerald Health Pharmaceuticals, Inc. has begun enrollment and has dosed its first patients with diffuse cutaneous systemic sclerosis in its Phase IIa clinical study of its lead product candidate, EHP-101, an oral formulation of a patented new chemical entity derived from cannabidiol.
    [Emerald Health Pharmaceuticals, Inc.]

    Press Release

    European Commission Grants Marketing Authorisation for World’s First Subcutaneous Formulation of Infliximab, Remsima® SC, for an Additional Five Indications including for Use in Inflammatory Bowel Disease and Ankylosing Spondylitis

    Celltrion Healthcare announced that the European Commission has granted marketing authorisation for Remsima® subcutaneous formulation for the treatment of adult patients with ankylosing spondylitis, Crohn’s disease, ulcerative colitis, psoriatic arthritis and psoriasis.
    [Celltrion Healthcare ]

    Press Release

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Autoimmune Pathogenesis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Researcher – Intestinal Immune Responses to Infection

    University of Dundee – Dundee, Scotland, United Kingdom

    Group Leader – Immune-Based Disorders and Infectious Diseases

    Institute of Parasitology and Biomedicine Lopez-Neyra – Granada, Spain

    Postdoctoral Positions – Cancer Epigenomics

    West Virginia University – Morgantown, West Virginia, United States

    Postdoctoral Researcher – Microbiome in Chronic Diseases

    University of Luxembourg – Luxembourg, Luxembourg

    > See All Jobs

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