Immune Regulation News Volume 12.28 | Aug 7 2020

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    IRN 12.28 | Aug 7


    Immune Regulation News by STEMCELL Technologies
    Vol. 12.28 – 7 August, 2020
    TOP STORY

    Immune Phenotyping of Diverse Syngeneic Murine Brain Tumors Identifies Immunologically Distinct Types

    Researchers generated distinct imageable syngeneic mouse glioblastoma-tumor models and utilized RNA-sequencing, CyTOF and correlative immunohistochemistry to assess immune-profiles in these models.
    [Nature Communications]

    Full Article

    Use ImmunoCultâ„¢ to differentiate mouse CD4+ cells to Tregs.
    PUBLICATIONSRanked by the impact factor of the journal

    Control of Viral Infection by Natural Killer Cell Inhibitory Receptors

    Investigators showed MHC-I-restricted control of murine cytomegalovirus (MCMV) infection in vivo that was NK cell dependent. Using mice lacking specific Ly49 receptors, they showed that control of MCMV required inhibitory Ly49 receptors and an inhibitory signaling motif and the capacity for MCMV to downregulate MHC-I.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Marginal Zone Formation Requires ACKR3 Expression on B Cells

    The authors showed that expression of atypical chemokine receptor 3 defined two equal-sized populations of mouse marginal B cells.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1+ Macrophages Regulates Intestinal Homeostasis

    Scientists demonstrated that intestinal G protein-coupled receptor 35 (Gpr35) expression was microbiota dependent and enhanced upon inflammation. Moreover, murine GPR35+ colonic macrophages were characterized by enhanced production of pro-inflammatory cytokines.
    [Cell Reports]

    Full ArticleGraphical Abstract

    High-Dimensional Single-Cell Analysis Delineates Radiofrequency Ablation Induced Immune Microenvironmental Remodeling in Pancreatic Cancer

    By using syngeneic tumor models and single-cell RNA and T-cell receptor sequencing, researchers investigated the alterations of tumor-infiltrating immune cells in distant non-radiofrequency ablation tumors.
    [Cell Death & Disease]

    Full Article

    Anti-Allergic Rhinitis Activity of α-Lipoic Acid via Balancing Th17/Treg Expression and Enhancing Nrf2/HO-1 Pathway Signaling

    Mice were orally administered various doses of α-Lipoic acid once daily and dexamethasone one hour before ovalbumin challenge.
    [Scientific Reports]

    Full Article

    CD122-Targetted IL-2 Signals Cause Acute and Selective Apoptosis of B Cells in Peyer’s Patches

    Scientists found that IL-2C targeting cells expressing IL-2 receptor beta caused an acute decrease in cellularity of Peyer’s Patches while cell numbers in the lamina propria and intraepithelial lymphocytes were unaffected.
    [Scientific Reports]

    Full Article

    A Novel Transgenic Mouse Strain Expressing PKCβII Demonstrates Expansion of B1 and Marginal Zone B Cell Populations

    The authors investigated the relative role of PKCβII in B cells by generating transgenic mice where expression of the transgene is directed to these cells using the Eµ promoter
    [Scientific Reports]

    Full Article

    Regulatory T Cells Are Less Sensitive to Glucocorticoid Hormone Induced Apoptosis than CD4+ T Cells

    Investigators analyzed the apoptosis-inducing effect of high dose in vitro dexamethasone treatment in mouse thymic- and splenic Tregs and CD4+ T cells.
    [Apoptosis]

    Full Article

    Magnesium Sulfate Prophylaxis Attenuates the Postpartum Effects of Preeclampsia by Promoting M2 Macrophage Polarization

    Timed-pregnant Sprague-Dawley rats received low-dose lipopolysaccharide on gestational day 14 to induce preeclampsia. Maternal and fetal outcomes and the macrophage profile one week after delivery were explored.
    [Hypertension Research]

    Abstract

    The Cytokine Receptor IL-7Rα Impairs IL-2 Receptor Signaling and Constrains the In Vitro Differentiation of Foxp3+ Treg Cells

    Researchers report that IL-7Rα downregulation was necessary to maximize IL-2R signaling. While IL-7Rα overexpression promoted IL-7 signaling, unexpectedly, IL-2 signaling was suppressed in the same cells.
    [iScience]

    AbstractGraphical Abstract

    Interleukin-10 and Small Molecule SHIP1 Allosteric Regulators Trigger Anti-Inflammatory Effects Through SHIP1/STAT3 Complexes

    Scientists report that IL10, but not IL6 signaling, induced formation of a complex between STAT3 and the inositol polyphosphate-5-phosphatase SHIP1 in macrophages.
    [iScience]

    AbstractFull ArticleGraphical Abstract

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    REVIEWS

    Immunostimulation with Chemotherapy in the Era of Immune Checkpoint Inhibitors

    Understanding the precise immunological mechanisms that underlie the efficacy of chemotherapy has the potential not only to enable the identification of superior biomarkers of response but also to accelerate the development of synergistic combination regimens that enhance the clinical effectiveness of immune checkpoint inhibitors relative to their effectiveness as monotherapies.
    [Nature Reviews Clinical Oncology]

    Abstract

    Pleiotropic Roles of Platelets and Neutrophils in Cell Death and Recovery during Acetaminophen Hepatotoxicity

    The role of platelets in liver biology and pathophysiology has attracted increased attention during the last decade.
    [Hepatology]

    Abstract

    INDUSTRY AND POLICY NEWS

    Corbus Pharmaceuticals Completes Enrollment in DETERMINE Phase III Study of Lenabasum for Treatment of Dermatomyositis

    Corbus Pharmaceuticals Holdings, Inc. announced the completion of subject enrollment in DETERMINE, a Phase III study assessing the efficacy and safety of lenabasum for the treatment of dermatomyositis. The company expects to report topline results from this study in the fourth quarter of 2021.
    [Corbus Pharmaceuticals Holdings, Inc.]

    Full Article

    GentiBio Launches to Develop Engineered Regulatory T Cells for Autoimmune and Inflammatory Diseases

    GentiBio, Inc. announced it has entered into exclusive licensing partnerships with Seattle Children’s Research Institute, Benaroya Research Institute at Virginia Mason, and MIGAL Galilee Research Institute to advance the company’s unique immune tolerance platform.
    [GentiBio, Inc.(EurekAlert!)]

    Press Release

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    JOB OPPORTUNITIES

    Postdoctoral Scientist – NLR, ALR and Type 1 Interferon Signaling

    Cedars-Sinai Hospital – Los Angeles, California, United States

    Postdoctoral Fellow – Autoimmune Pathogenesis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    Postdoctoral Researcher – Intestinal Immune Responses to Infection

    University of Dundee – Dundee, United Kingdom

    Group Leader – Immune-Based Disorders and Infectious Diseases

    Institute of Parasitology and Biomedicine Lopez-Neyra – Granada, Spain

    Postdoctoral Positions – Cancer Epigenomics

    West Virginia University – Morgantown, West Virginia, United States

    > See All Jobs

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