Immune Regulation News Volume 12.30 | Aug 21 2020

May 12, 2022

IRN 12.30 | August 21

Immune Regulation News by STEMCELL Technologies

Vol. 12.30 – 21 August, 2020

TOP STORY

C9orf72 in Myeloid Cells Suppresses STING-Induced Inflammation

Investigators showed in mice that loss of C9orf72 from myeloid cells alone was sufficient to recapitulate the age-dependent lymphoid hypertrophy and autoinflammation seen in animals with a complete knockout of C9orf72.
[Nature]

Abstract Press Release

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PUBLICATIONSRanked by the impact factor of the journal

Functional
Effects of Chimeric Antigen Receptor Co-Receptor Signaling Domains in Human Regulatory T Cells

Using a human leukocyte antigen–A2–specific chimeric antigen receptor (CAR) platform and human T_regs, the authors compared 10 CARs with different co-receptor signaling domains and systematically tested their function and CAR-stimulated gene expression profile.
[Science Translational Medicine]

Abstract

Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction

Investigators employed single-cell transcriptomics combined with cell surface epitope detection by sequencing to investigate temporal neutrophil diversity in the blood and heart after murine myocardial infarction.
[Circulation Research]

Abstract

Enhanced
Cancer DNA Vaccine via Direct Transfection to Host Dendritic Cells Recruited in Injectable Scaffold

Researchers proposed the enhanced cancer DNA vaccine by direct transfection to the high number of dendritic cells recruited into the chemoattractant-loaded injectable mesoporous silica microrods.
[ACS Nano]

Abstract

Mef2d Sustains Activation of Effector Foxp3⁺
Tregs during Transplant Survival and Anticancer Immunity

Mice with the conditional deletion in Tregs of the gene encoding Mef2d were unable to maintain long-term allograft survival despite costimulation blockade and had enhanced antitumor immunity in syngeneic models, but they displayed only minor evidence of autoimmunity when maintained under normal conditions.
[Journal of Clinical Investigation]

Abstract Full Article
Graphical Abstract

Antibody-Secreting
Cell Destiny Emerges during the Initial Stages of B-Cell Activation

Scientists investigated B cell fate programming and heterogeneity during anti-body secreting cells (ASCs) differentiation using T cell-independent models. They found that maximal ASC induction required at least eight cell divisions in vivo, with BLIMP-1 being required for differentiation at division eight.
[Nature Communications]

Full Article

PD-1
Pathway Regulates ILC2 Metabolism and PD-1 Agonist Treatment Ameliorates Airway Hyperreactivity

The authors investigated PD-1 function in pulmonary innate lymphoid cells (ILC2s) during IL-33-induced airway inflammation. PD-1 limited the viability of type-2 innate lymphoid cells (ILC2s) and downregulated their effector functions.
[Nature Communications]

Full Article

HFE
Inhibits Type I IFNs Signaling by Targeting the SQSTM1-Mediated MAVS Autophagic Degradation

Scientists identified five iron metabolism-associated genes specifically affected during RNA virus infection by a high-throughput assay and further found that HFE was a key negative regulator of RIG-I-like receptors-mediated type I interferons signaling.
[Autophagy]

Full Article

Defined Microbiota Transplant Restores Th17/RORγt⁺
Regulatory T Cell Balance in Mice Colonized with Inflammatory Bowel Disease Microbiotas

Mice colonized with inflammatory bowel disease donor-derived microbiotas exhibit a stereotypical set of phenotypes, characterized by abundant mucosal Th17 cells, a deficit in the tolerogenic RORγt+ regulatory T cell subset, and susceptibility to disease in colitis models.
[Proceedings of the National Academy of Sciences of the United States of America]

Full Article

PPARγ
Enhances ILC2 Function during Allergic Airway Inflammation via Transcription Regulation of ST2

The authors identified PPARγ as a positive regulator of lung Group 2 innate lymphoid cells (ILC2). Expression of PPARγ on ILC2 was dramatically induced upon interleukin-33 challenge.
[Mucosal Immunology]

Abstract

A
Monoclonal Antibody to Siglec-8 Suppresses Non-Allergic Airway Inflammation and Inhibits IgE-Independent Mast Cell Activation

Investigators evaluated the effects of an anti-Siglec-8 monoclonal antibody in non-allergic disease models of experimental cigarette-smoke-induced chronic obstructive pulmonary disease and bleomycin-induced lung injury in Siglec-8 transgenic mice.
[Mucosal Immunology]

Full Article

Typically
Inhibiting USP14 Promotes Autophagy in M1-Like Macrophages and Alleviates CLP-Induced Sepsis

Researchers verified that neochromine S5 significantly inhibited M1-like macrophage polarization with decrease of the proinflammatory cytokines and downregulation of NF-κB and STAT1 signals.
[Cell Death & Disease]

Full Article

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REVIEWS

Identifying
and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors

Scientists discuss molecular identification of different tumor antigen types, and the clinical safety and efficacy of targeting them with immunotherapy.
[Cancer Cell]

Abstract

INDUSTRY AND POLICY NEWS

Zosano
Pharma Announces Agreement to Collaborate with Mitsubishi Tanabe Pharma Corporation

Zosano Pharma Corporation announced that it has entered into a feasibility study agreement with Mitsubishi Tanabe Pharma Corporation centered on its priority disease areas — autoimmune diseases, diabetes and kidney diseases, central nervous system diseases, and vaccines.
[ Zosano Pharma Corporation]

Press Release

FDA Approves Novartis Kesimpta^® (Ofatumumab), the First and Only Self-Administered, Targeted B-Cell Therapy for Patients with Relapsing Multiple Sclerosis

Novartis announced that the FDA has approved Kesimpta^® as an injection for subcutaneous use for the treatment of relapsing forms of multiple sclerosis, to include clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, in adults.
[Novartis]

Press Release

FEATURED EVENT

C9orf72 in Myeloid Cells Suppresses STING-Induced Inflammation

Functional
Effects of Chimeric Antigen Receptor Co-Receptor Signaling Domains in Human Regulatory T Cells

Dynamics of Cardiac Neutrophil Diversity in Murine Myocardial Infarction

Enhanced
Cancer DNA Vaccine via Direct Transfection to Host Dendritic Cells Recruited in Injectable Scaffold

Mef2d Sustains Activation of Effector Foxp3⁺
Tregs during Transplant Survival and Anticancer Immunity

Antibody-Secreting
Cell Destiny Emerges during the Initial Stages of B-Cell Activation

PD-1
Pathway Regulates ILC2 Metabolism and PD-1 Agonist Treatment Ameliorates Airway Hyperreactivity

HFE
Inhibits Type I IFNs Signaling by Targeting the SQSTM1-Mediated MAVS Autophagic Degradation

Defined Microbiota Transplant Restores Th17/RORγt⁺
Regulatory T Cell Balance in Mice Colonized with Inflammatory Bowel Disease Microbiotas

PPARγ
Enhances ILC2 Function during Allergic Airway Inflammation via Transcription Regulation of ST2

A
Monoclonal Antibody to Siglec-8 Suppresses Non-Allergic Airway Inflammation and Inhibits IgE-Independent Mast Cell Activation

Typically
Inhibiting USP14 Promotes Autophagy in M1-Like Macrophages and Alleviates CLP-Induced Sepsis

Identifying
and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors

Zosano
Pharma Announces Agreement to Collaborate with Mitsubishi Tanabe Pharma Corporation

FDA Approves Novartis Kesimpta^® (Ofatumumab), the First and Only Self-Administered, Targeted B-Cell Therapy for Patients with Relapsing Multiple Sclerosis

CAR-T Beyond Oncology Digital Event

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Host – The Immunology Podcast

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Scientist – NLR, ALR and Type 1 Interferon Signaling

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Fellow – Autoimmune Pathogenesis

Postdoctoral
Researcher – Intestinal Immune Responses to Infection

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Positions – Cancer Epigenomics

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