| Vol. 12.32 – 4 September, 2020 |
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| Mechanistically, tumor cells avidly consumed methionine and outcompeted T cells for methionine by expressing high levels of the methionine transporter SLC43A2. [Nature] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists showed that Nr4a1 and Nr4a3 played partially redundant roles to restrain B cell responses to antigen in the absence of co-stimulation and did so, in part, by repressing the expression of BATF and, consequently, MYC. [Nature Immunology] |
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| Investigators showed how that HIF activity was high in human and murine bone marrow pro-B and pre-B cells and decreased at the immature B cell stage. [Nature Immunology] |
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| Scientists demonstrated that Kupffer cells (KCs) were reduced in metabolic-associated fatty liver disease, being replaced by macrophages originating from the bone marrow. Recruited macrophages existed in two subsets with distinct activation states, either closely resembling homeostatic KCs or lipid-associated macrophages from obese adipose tissue. [Immunity] |
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| Acute lung injury-induced HMGB1 leaked and was captured by arterial macrophages thereby altering their mitochondrial metabolism through RIPK3. [Nature Communications] |
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| Researchers identified analogous effector subsets of three innate T cell types in the thymus that share transcriptional profiles. [Nature Communications] |
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| The authors report a living zebrafish model that allowed the visualization the metastatic cancer cell killing effect by tumor- infiltrating lymphocytes (TILs) and CAR-T cells in vivo at the single-cell level. In a freshly isolated primary human melanoma, specific TILs effectively eliminated metastatic cancer cells in the living body. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Scientists showed that Atxn1-null mice developed a more severe experimental autoimmune encephalomyelitis course compared to wildtype mice. The aggravated phenotype was mediated by increased T helper type 1 cell polarization, which in turn resulted from the dysregulation of B cell activity. [Proceedings of the National Academy of Sciences of the United States of America] |
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| To characterize tumor-infiltrating regulatory T cells (Tregs), investigators performed bulk RNA-seq and found that proliferation-related genes, immune suppression-related genes, and cytokine/chemokine receptor genes were upregulated in tumor-infiltrating Tregs compared to tumor-infiltrating CD4+Foxp3− conventional T cells or splenic Tregs from the same tumor-bearing mice. [Cancer Immunology Research] |
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| TLR4‐induced innate immune functions, including phagocytosis and iNOS expression, were attenuated in autotaxin‐deficient macrophages. [EMBO Reports] |
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| Chimeric mice deficient for Notch3 in hematopoietic cells and/or resident tissue cells were generated, and kidney fibrosis and inflammation after unilateral ureteral obstruction were analyzed. [Journal of the American Society of Nephrology] |
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| Repeated exposure to anti-4-1BB mAbs led to granuloma development in tumor-draining lymph nodes of mice due to recruitment and accumulation of macrophages via the CD8+ T cell-IFN-γ axis. [Cellular & Molecular Immunology] |
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| The authors identify 291 drugs that target 99 unique ligands, and they discuss trends in the characteristics of the ligands, drugs and indications for which they have been tested. [Nature Reviews Drug Discovery] |
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| Investigators describe the cognitive impairment associated with each antibody-mediated syndrome and, using evidence from imaging and animal studies, examined how the nature of the impairment related to the underlying neuroimmunological and receptor-based mechanisms. [Translational Psychiatry] |
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| Mustang Bio, Inc. announced that the FDA has granted Rare Pediatric Disease Designation to MB-207, Mustang’s lentiviral gene therapy for the treatment of patients with X-linked severe combined immunodeficiency, also known as bubble boy disease, who were previously treated with a hematopoietic stem cell transplantation and for whom re-treatment is indicated. [Mustang Bio, Inc.] |
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| Banner Life Sciences LLC announced that BAFIERTAM™ , a novel fumarate for the treatment of relapsing forms of multiple sclerosis in adults, including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease, has commercially launched and is now available in the US. [Banner Life Sciences LLC] |
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| University Hospital Erlangen – Erlagen, Germany |
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| MD Anderson Cancer Center – Houston, Texas, United States |
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| University of Washington – Seattle, Washington, United States |
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| STEMCELL Technologies – Flexible |
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| Cedars-Sinai Hospital – Los Angeles, California, United States |
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