Immune Regulation News Volume 12.33 | Sep 11 2020

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    IRN 12.33 | Sept 11


    Immune Regulation News by STEMCELL Technologies
    Vol. 12.33 – 11 September, 2020
    TOP STORY

    Limited
    Proliferation Capacity of Aortic Intima Resident Macrophages Requires Monocyte Recruitment for Atherosclerotic Plaque Progression

    Using murine lineage-tracing models and gene expression profiling, scientists revealed that myeloid cells present in the intima of the aortic arch were not dendritc cells but instead specialized aortic intima resident macrophages that depended upon colony-stimulating factor 1 and are sustained by local proliferation.
    [Nature Immunology]

    Abstract


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    PUBLICATIONSRanked by the impact factor of the journal

    Maintenance
    DNA Methylation Is Essential for Regulatory T Cell Development and Stability of Suppressive Function

    Researchers demonstrated that the epigenetic regulator Uhrf1 was essential for maintenance of methyl-DNA marks that stabilized Treg cellular identity by repressing effector T cell transcriptional programs.
    [Journal of Clinical Investigation]

    AbstractFull Article
    Graphical Abstract

    Transgenerational Inheritance of Impaired Larval T Cell Development in Zebrafish

    Investigators describe a viable hypomorphic allele of dnmt1 in zebrafish that caused widespread demethylation of CpG dinucleotides in sperm and somatic tissues.
    [Nature Communications]

    Full Article

    Dual
    Roles of Neutrophils in Metastatic Colonization Are Governed by the Host NK Cell Status

    The authors demonstrated that the metastasis-modulating effects of neutrophils were dictated by the status of host NK cells.
    [Nature Communications]

    Full Article

    Glufosinate
    Constrains Synchronous and Metachronous Metastasis by Promoting Anti-Tumor Macrophages

    Scientists evaluated the pharmacological potential of glutamine synthetase (GS) inhibitors in targeting metastasis, identifying glufosinate as a specific human GS inhibitor.
    [EMBO Molecular Medicine]

    Full ArticleGraphical Abstract

    Early Programming of CD8+
    T Cell Response by the Orphan Nuclear Receptor NR4A3

    Investigators showed that NR4A3-deficient murine CD8+ T cells differentiated preferentially into memory precursor and central memory cells, but also produced more cytokines.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Enteric
    Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation

    Scientists manipulated a major mechanism of glial intercellular communication that required connexin-43 and assessed the effects on acute and chronic inflammation, visceral hypersensitivity, and immune responses.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Kidney GATA3+
    Regulatory T Cells Play Roles in the Convalescence Stage after Antibody-Mediated Renal Injury

    In an experimental mouse model of crescentic glomerulonephritis induced by an anti-glomerular basement membrane antibody, Tregs started to accumulate in the kidney on day ten of disease onset and remained at high levels during the late stage, which correlated with stable disease control.
    [Cellular & Molecular Immunology]

    Full Article

    A
    Small Molecular Compound CC1007 Induces Cross-Lineage Differentiation by Inhibiting HDAC7 Expression and HDAC7/MEF2C Interaction in BCR-ABL− Pre-B-ALL

    The authors investigated the anticancer effects of CC1007 in breakpoint cluster region-Abelson 1 fusion gene-negative (BCR-ABL1−) pre-B cell acute lymphoblastic leukemia (B-ALL) cell lines and primary patient-derived BCR-ABL1− pre-B-ALL cells.
    [Cell Death & Disease]

    Full Article

    Development
    of Humanized Mouse and Rat Models with Full-Thickness Human Skin and Autologous Immune Cells

    Researchers introduced the human skin and immune system-humanized NOD-scid IL2Rγnull mouse and Sprague–Dawley-Rag2tm2hera Il2rγtm1hera rat models, co-engrafted with human full-thickness fetal skin, autologous fetal lymphoid tissues, and autologous fetal liver-derived hematopoietic stem cells.
    [Scientific Reports]

    Full Article

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    REVIEWS

    Genetic Models of Human and Mouse Dendritic Cell Development and Function

    Investigators discuss genetic models of mouse dendritic cells (DCs) development and function that have aided in correlating ontogeny with function, as well as how these findings can be translated to human DCs and their progenitors.
    [Nature Reviews Immunology]

    Abstract

    The
    Effects of Different Dietary Fiber Pectin Structures on the Gastrointestinal Immune Barrier: Impact via Gut Microbiota and Direct Effects on Immune Cells

    The effects of pectin include strengthening the mucus layer, enhancing epithelial integrity, and activating or inhibiting dendritic cell and macrophage responses.
    [Experimental and Molecular Medicine]

    Full Article

    Tissue-Specific Features of Innate Lymphoid Cells

    The authors summarize current knowledge of innate lymphoid cell (ILC) phenotypes in various tissues in mice and humans, aiming to clarify ILC immunity in distinct anatomical locations.
    [Trends in Immunology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Atara
    Biotherapeutics Announces All Progressive Multiple Sclerosis Patients with Sustained Disability Improvement at Six Months Confirmed Improvement at 12 Months in the Phase Ia Study of ATA188

    Atara Biotherapeutics, Inc. announced the presentation of data from the first part of the ongoing Phase I study of ATA188 for the treatment of progressive forms of multiple sclerosis.
    [Atara Biotherapeutics, Inc.]

    Press Release

    Arcutis
    Biotherapeutics to Accelerate ARQ-151 (Topical Roflumilast Cream) into Phase III Trials for the Treatment of Atopic Dermatitis Following End-of-Phase II Meeting with FDA

    Arcutis Biotherapeutics, Inc. announced plans to advance its program to develop ARQ-151 for the treatment of atopic dermatitis into Phase III clinical trials following its End-of-Phase II meeting with the FDA, without conducting the previously planned Phase IIb atopic dermatitis trial.
    [Arcutis Biotherapeutics, Inc.]

    Press Release

    Cancer
    Research Institute Announces Recipients of 2020 Philanthropy and Science Awards to be Presented at Virtual Gala, Innovators in Science and Philanthropy

    The Cancer Research Institute announced the 2020 recipients of its highest scientific and philanthropic awards. CRI will present the awards to seven honorees during its annual gala, Innovators in Science and Philanthropy, which CRI is hosting virtually for the first time.
    [Cancer Research Institute ]

    Press Release

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