 | | Vol. 12.34 – 18 September, 2020 |
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| Scientists employed synTacs, which are dimeric major histocompatibility molecule scaffolds of defined composition. SynTacs, when labeled with positron-emitting isotopes, could noninvasively image antigen-specific CD8+ T cells in vivo.
[Nature Methods] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers found that interleukin-6- and STAT3 transcription factor-dependent upregulation of Notch4 receptor on lung tissue regulatory T cells was necessary for allergens and particulate matter pollutants to promote airway inflammation.
[Nature Immunology] |
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| Investigators identified a gradient of increasing glucocorticoid receptor expression and signaling from naïve to dysfunctional CD8+ tumor-infiltrating lymphocytes.
[Immunity] |
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| Researchers describe a clot Treg population that forms the matricellular acid- and cysteine-rich protein (SPARC), and showed that SPARC enhanced monocyte matrix metalloproteinase activity and that SPARC+ Tregs were crucial for blood clot resorption.
[Blood] |
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| Exercise training preconditioning mitigated the inflammatory response to liver ischemia‐reperfusion injury, protecting the liver from injury and metastases.
[Hepatology] |
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| With murine and humanized MHC–/–HLA–A2+DR4+ murine models of chronic graft-versus-host disease (GvHD), researchers showed that both murine and human PSGL1loCD4+ T cells from GvHD target tissues have features of B cell helpers with upregulated-expression of PD1 and ICOS and production of IL-21.
[Journal of Clinical Investigation] |
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| The authors identified major transcriptional networks deregulated in diabetic foot ulcers that resulted in decreased neutrophils and macrophages recruitment and overall poorly controlled inflammatory response.
[Nature Communications] |
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| Investigators showed that selective blockade of TGF-β1 production by Tregs with antibodies against GARP:TGF-β1 complexes induced regressions of mouse tumors otherwise resistant to anti-PD-1 immunotherapy.
[Nature Communications] |
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| Scientists showed that IL‐2 signaling was required to maintain open chromatin at hundreds of gene regulatory elements, many of which control subsequent stimulus‐dependent alternative pathways of T cell differentiation.
[EMBO Journal] |
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| Researchers report that phosphorylation of a specific tyrosine residue in STING by the epidermal growth factor receptor (EGFR) is required for directing stimulator of interferon genes (STING) to endosomes, where it interacted with its downstream effector IRF3.
[EMBO Journal] |
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| The authors demonstrated that P2X7 was highly expressed in tumor-associated macrophages (TAMs) and that P2X7 deficiency impaired the “M2-like” polarization of TAMs via down-regulation of STAT6 and IRF4 phosphorylation both in vivo and in vitro.
[Cancer Immunology Research] |
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| Researchers found that the chemokines CXCL1 and CCL2 were induced in the brain following herpes simplex virus-1 infection. Ccr2-deficient mice had reduced monocyte recruitment, uncontrolled viral replication, and increased morbidity.
[Cell Reports] |
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| To find cellular defects triggered by tumor exposure and associated PD-1 signaling, scientists established an ex vivo imaging approach to investigate the response of antigen-specific, activated effector CD8+ tumor-infiltrating lymphocytes after interaction with target tumor cells.
[Science Signaling] |
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| Researchers describe some of the sensory stimuli that macrophages perceive and the responses they make to various stimuli to achieve their prime directive, which is the maintenance of homeostasis.
[Cellular & Molecular Immunology] |
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| Investigators summarize advances in research on the most prominent immune effectors in cancer and cancer immunotherapy, cytotoxic T cells, and discuss possible implications for future cancer treatment.
[British Journal of Cancer] |
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| Scientists focus on the pivotal roles of class I phosphoinositide 3-kinases (PI3Ks) in adaptive and innate immune cells, as well as other stromal components. They discuss the modulation by PI3K inhibitors of the tumor-supportive microenvironment, including eliminating the regulatory immune cells, restoring cytotoxic cells or regulating angiogenesis.
[Acta Pharmacologica Sinica] |
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| Tmunity Therapeutics, Inc. announced that it has dosed the first patient in its Phase I CART-TnMUC1-01 clinical trial with the Tn/STn glycoform of mucin 1 (TnMUC1) CAR-T therapy in patients with TnMUC1-positive advanced cancers.
[Tmunity Therapeutics, Inc.] |
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| CEL-SCI Corporation announced that the European Patent Office has issued CEL-SCI patent: European Patent 2989121 titled “Method of Preparation and Composition of Peptide Constructs for Treatment of Rheumatoid Arthritis” for the company’s LEAPS platform technology.
[CEL-SCI Corporation] |
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| Artax Biopharma, Inc. announced that the United States Patent and Trademark Office has granted a composition of matter patent for AX-158, the Company’s lead autoimmune therapeutic candidate.
[Artax Biopharma, Inc.] |
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| May 7 – May 11, 2021
Castelnuovo Berardenga Italy |
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| | Texas Biomedical Research Institute – San Antonio, Texas, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| | STEMCELL Technologies – Flexible |
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| | University Hospital Erlangen – Erlagen, Germany |
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| | Cedars-Sinai Hospital – Los Angeles, California, United States |
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