Immune Regulation News Volume 12.43 | Nov 13 2020

May 12, 2022

IRN 12.43 | Nov 13 2020

Immune Regulation News by STEMCELL Technologies

Vol. 12.43 – 13 November, 2020

TOP STORY

CRELD1 Modulates Homeostasis of the Immune System in Mice and Humans

Scientists provide evidence that CRELD1, a pivotal factor for heart development, was an important gatekeeper of immune system homeostasis.
[Nature Immunology]

Abstract

Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.

PUBLICATIONSRanked by the impact factor of the journal

Repetitive
Elements Trigger RIG-I-Like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells

Rig-I or Mda5 deficiency reduced hematopoietic stem and progenitor cell numbers by inhibiting inflammatory signals that were in turn enhanced in Lgp2 deficient embryos.
[Immunity]

Abstract Graphical Abstract

iPSC-Derived NK Cells Maintain High Cytotoxicity and Enhance In Vivo
Tumor Control in Concert with T Cells and Anti–PD-1 Therapy

Natural killer (NK) cells have the potential to augment checkpoint inhibition therapies, such as PD-L1/PD-1 blockade, because NK cells mediate both direct tumor lysis and T cell activation and recruitment.
[Science Translational Medicine]

Abstract

Oligodendrocyte-Derived
Extracellular Vesicles As Antigen-Specific Therapy for Autoimmune Neuroinflammation in Mice

Intravenous oligodendrocyte-derived extracellular vesicles injection reduced disease pathophysiology in a myelin Ag–dependent manner, both prophylactically and therapeutically, in several experimental autoimmune encephalomyelitis models.
[Science Translational Medicine]

Abstract

Inhibition
of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Scientists report that limiting glutamine metabolism in cancer cells bolstered the effectiveness of anti-programmed death ligand-1 antibody.
[Molecular Cell]

Abstract Graphical Abstract

Dermal IRF4⁺ Dendritic Cells and Monocytes License CD4⁺
T Helper Cells to Distinct Cytokine Profiles

Researchers used skin-relevant, fluorescently-labeled bacterial, helminth or fungal pathogens to track and characterize the antigen-presenting cell populations that drove helper T responses in vivo.
[Nature Communications]

Full Article

Homeostatic and Early-Recruited CD101⁻
Eosinophils Suppress Endotoxin-Induced Acute Lung Injury

Blood eosinophils were increased in surviving patients with acute respiratory distress syndrome independent of corticosteroid usage. The homeostatic eosinophils in mice lung parenchyma, originating from the bone marrow, were predominantly CD101⁻.
[European Respiratory Journal]

Abstract

PTRF/Cavin1
Remodels Phospholipid Metabolism to Promote Tumor Proliferation and Suppress Immune Responses in Glioblastoma by Stabilizing cPLA2

Scientists showed that polymerase 1 and transcript release factor (PTRF) triggered a cytoplasmic phospholipase A2-mediated phospholipid remodeling pathway that promotes glioblastoma tumor proliferation and suppressed tumor immune responses.
[Neuro-Oncology]

Abstract

ZMYND8
Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth

ZMYND8 knockout (KO) in breast cancer cells promoted infiltration of CD4⁺ and CD8⁺ T cells leading to tumor inhibition in syngeneic mouse models, which was significantly attenuated by treatment of anti-CD4/CD8 depleting antibodies or anti-IFNAR1 antibody and in immunodeficient Rag1 KO mice.
[Cancer Research]

Abstract

Expression
of the Chemokine Receptor CCR1 Promotes the Dissemination of Multiple Myeloma Plasma Cells In Vivo

Scientists demonstrated that CCR1 expression was an independent prognostic indicator in newly diagnosed multiple myeloma patients.
[Haematologica]

Abstract

Human
and Mouse Transcriptome Profiling Identifies Cross-Species Homology in Pulmonary and Lymph Node Mononuclear Phagocytes

Investigators created a gene expression compendium across 24 distinct human and murine lung and lymph node mononuclear phagocytes (MPs), along with human blood and murine spleen MPs, to serve as validation datasets.
[Cell Reports]

Full Article Graphical Abstract

Request your free copy of the 'Human Immune Cytokines' Wallchart

REVIEWS

New Insights Into the Basic Biology of Acute Graft-versus-Host-Disease

The authors focus on new findings that clarify the roles specific epigenetic regulators play in T cell-mediated acute graft-versus-host-disease development and discuss how their modulation could disrupt that process to beneficial effects.
[Haematologica]

Full Article

Neutrophils in Liver Diseases: Pathogenesis and Therapeutic Targets

Currently, neutrophils, with their autocrine, paracrine, and immune modulation functions, have been shown to be involved in liver diseases, including viral hepatitis, nonalcoholic steatohepatitis, alcoholic liver disease, liver fibrosis, cirrhosis, liver failure, and liver cancer. Scientists summarize the role of neutrophils in liver diseases.
[Cellular & Molecular Immunology]

Full Article

INDUSTRY AND POLICY NEWS

XNK
Therapeutics Receives US Orphan Drug Status for NK Cell-Based Immunotherapy in Multiple Myeloma

XNK Therapeutics AB announced it has received Orphan Drug Designation from the FDA for its leading investigational drug candidate in the treatment of multiple myeloma.
[XNK Therapeutics AB]

Press Release

FEATURED EVENT

CRELD1 Modulates Homeostasis of the Immune System in Mice and Humans

Repetitive
Elements Trigger RIG-I-Like Receptor Signaling that Regulates the Emergence of Hematopoietic Stem and Progenitor Cells

iPSC-Derived NK Cells Maintain High Cytotoxicity and Enhance In Vivo
Tumor Control in Concert with T Cells and Anti–PD-1 Therapy

Oligodendrocyte-Derived
Extracellular Vesicles As Antigen-Specific Therapy for Autoimmune Neuroinflammation in Mice

Inhibition
of Glutamine Utilization Synergizes with Immune Checkpoint Inhibitor to Promote Antitumor Immunity

Dermal IRF4⁺ Dendritic Cells and Monocytes License CD4⁺
T Helper Cells to Distinct Cytokine Profiles

Homeostatic and Early-Recruited CD101⁻
Eosinophils Suppress Endotoxin-Induced Acute Lung Injury

PTRF/Cavin1
Remodels Phospholipid Metabolism to Promote Tumor Proliferation and Suppress Immune Responses in Glioblastoma by Stabilizing cPLA2

ZMYND8
Expression in Breast Cancer Cells Blocks T-Lymphocyte Surveillance to Promote Tumor Growth

Expression
of the Chemokine Receptor CCR1 Promotes the Dissemination of Multiple Myeloma Plasma Cells In Vivo

Human
and Mouse Transcriptome Profiling Identifies Cross-Species Homology in Pulmonary and Lymph Node Mononuclear Phagocytes

New Insights Into the Basic Biology of Acute Graft-versus-Host-Disease

Neutrophils in Liver Diseases: Pathogenesis and Therapeutic Targets

XNK
Therapeutics Receives US Orphan Drug Status for NK Cell-Based Immunotherapy in Multiple Myeloma

Keystone
Symposia: Fatty Liver Disease and Multi-System Complications

> See All Events

Associate
Program Director – Inflammatory Bowel Disease

Tier 2 Canada Research Chair – Immunology and Inflammation

Research
Group Leader – Immunology and Infection

Senior
Scientific Researcher – Immunology Discovery

Research
Positions – Cancer and Immunotherapy

> See All Jobs