Immune Regulation News Volume 12.44 | Nov 20 2020

May 12, 2022

122

IRN 12.44 | Nov 20 2020

Immune Regulation News by STEMCELL Technologies

Vol. 12.44 – 20 November, 2020

TOP STORY

CD25-T_reg-Depleting
Antibodies Preserving IL-2 Signaling on Effector T Cells Enhance Effector Activation and Antitumor Immunity

Scientists demonstrated potent single-agent activity of anti-CD25 antibodies optimized to deplete T_reg cells, while preserving IL-2-STAT5 signaling on effector T cells and showed synergy with immune checkpoint blockade in vivo.
[Nature Cancer]

Abstract Press Release

New human primary cell products—frozen leukopaks, regulatory T cells, and more. Click to view products.

PUBLICATIONSRanked by the impact factor of the journal

Small-Molecule-Induced Polymerization Triggers Degradation of BCL6

Researchers report an alternative mechanism of targeted protein degradation, in which a small molecule induced the highly specific, reversible polymerization of a target protein, followed by its sequestration into cellular foci and subsequent degradation.
[Nature]

Full Article

Protein
Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T_reg Cells

Investigators showed that isoprenoid-dependent posttranslational lipid modifications dictated effector regulatory T cell accumulation and function by intersecting with T cell receptor-induced intracellular signaling.
[Cell Metabolism]

Abstract Graphical Abstract
Press Release

Competition
for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

The authors found that the source of transforming growth factor-β-supporting resident memory T cells was autocrine.
[Immunity]

Abstract
Graphical Abstract

Senescent Cells Promote Tissue NAD⁺
Decline during Aging via the Activation of CD38⁺ Macrophages

Researchers showed that pro-inflammatory M1-like macrophages, but not naive or M2 macrophages, accumulate in metabolic tissues, including visceral white adipose tissue and liver, during ageing and acute responses to inflammation.
[Nature Metabolism]

Abstract
Press Release

CD38 Ecto-Enzyme in Immune Cells Is Induced during Aging and Regulates NAD⁺
and NMN Levels

Scientists showed that an increase in CD38 in white adipose tissue and the liver during aging was mediated by accumulation of CD38⁺ immune cells. Inflammation increased CD38 and decreased NAD⁺.
[Nature Metabolism]

Abstract
Press Release

Endothelial
p300 Promotes Portal Hypertension and Hepatic Fibrosis through CCL2-Mediated Angiocrine Signaling

In vitro, epigenome‐editing of carbon tetrachloride (CCL2) enhancer and promoter regions by CRISPR‐dCas9‐KRAB technology repressed TNFα‐induced CCL2 transcription via H3K9 tri‐methylation.
[Hepatology]

Abstract

Cellular Context of IL-33 Expression Dictates Impact on Anti-Helminth Immunity

Scientists demonstrated that cell-intrinsic IL-33 promoted mouse dendritic cells to express the pore-forming protein perforin-2, which may function as a conduit on the plasma membrane facilitating IL-33 export.
[Science Immunology]

Abstract
Press Release

Characterisation of CD4⁺
T-Cell Subtypes Using Single Cell RNA Sequencing and the Impact of Cell Number and Sequencing Depth

The authors found that the reparative macrophage transition was dictated by B-cell adapter for PI3K (BCAP). Mice harboring a macrophage-specific deletion of BCAP fail to recover from and succumb to dextran sulfate sodium-induced colitis due to prolonged intestinal inflammation and impaired tissue repair.
[Proceedings of the National Academy of Sciences of the United States of America]

Abstract

Targeted
Deletion of CXCR2 in Myeloid Cells Alters the Tumor Immune Environment to Improve Antitumor Immunity

Recruitment of myeloid-derived suppressor cells into the tumor microenvironment contributes to cancer immune evasion. Scientists compared the growth and metastasis of melanoma and breast cancer xenografts in mice exhibiting or not exhibiting targeted deletion of Cxcr2 in myeloid cells.
[Cancer Immunology Research]

Abstract

CSF1R
Inhibition Depletes Tumor-Associated Macrophages and Attenuates Tumor Progression in a Mouse Sonic Hedgehog-Medulloblastoma Model

By combining longitudinal manganese-enhanced magnetic resonance imaging and immune profiling of a sporadic mouse model of sonic hedgehog subgroup of medulloblastoma, researchers found the density of tumor-associated macrophages/microglia was higher in the ~50% of tumors that progress to lethal disease.
[Oncogene]

Abstract

Platelet PD-L1 Suppresses Anti-Cancer Immune Cell Activity in PD-L1 Negative Tumors

Investigators showed that platelet-derived programmed cell death protein-1 (PD-L1) regulated the growth of PD-L1 negative tumors and that interference with platelet binding to PD-L1 negative cancer cells promoted T cell-induced cancer cytotoxicity.
[Scientific Reports]

Full Article

Request a copy of the COVID-19 wallchart.

REVIEWS

Macrophage Metabolic Reprogramming during Chronic Lung Disease

The authors focus on how metabolic alterations underlie airway macrophage phenotype and function during chronic lung diseases.
[Mucosal Immunology]

Full Article

INDUSTRY AND POLICY NEWS

Proteintech
and HebeCell Announce Collaboration on Nanobody iPSC-derived Natural Killer Cells

Proteintech and HebeCell announced their collaborative partnership to develop proprietary nanobody based chimeric antigen receptor technology for the development and commercialization of iPSC-derived natural killer cells, a promising cellular immunotherapy treatment for cancer and other diseases.
[Proteintech]

Press Release

FEATURED EVENT

CD25-T_reg-Depleting
Antibodies Preserving IL-2 Signaling on Effector T Cells Enhance Effector Activation and Antitumor Immunity

Small-Molecule-Induced Polymerization Triggers Degradation of BCL6

Protein
Prenylation Drives Discrete Signaling Programs for the Differentiation and Maintenance of Effector T_reg Cells

Competition
for Active TGFβ Cytokine Allows for Selective Retention of Antigen-Specific Tissue- Resident Memory T Cells in the Epidermal Niche

Senescent Cells Promote Tissue NAD⁺
Decline during Aging via the Activation of CD38⁺ Macrophages

CD38 Ecto-Enzyme in Immune Cells Is Induced during Aging and Regulates NAD⁺
and NMN Levels

Endothelial
p300 Promotes Portal Hypertension and Hepatic Fibrosis through CCL2-Mediated Angiocrine Signaling

Cellular Context of IL-33 Expression Dictates Impact on Anti-Helminth Immunity

Characterisation of CD4⁺
T-Cell Subtypes Using Single Cell RNA Sequencing and the Impact of Cell Number and Sequencing Depth

Targeted
Deletion of CXCR2 in Myeloid Cells Alters the Tumor Immune Environment to Improve Antitumor Immunity

CSF1R
Inhibition Depletes Tumor-Associated Macrophages and Attenuates Tumor Progression in a Mouse Sonic Hedgehog-Medulloblastoma Model

Platelet PD-L1 Suppresses Anti-Cancer Immune Cell Activity in PD-L1 Negative Tumors

Macrophage Metabolic Reprogramming during Chronic Lung Disease

Proteintech
and HebeCell Announce Collaboration on Nanobody iPSC-derived Natural Killer Cells

The American Association for Cancer Research (AACR) Annual Meeting 2021

> See All Events

Scientist – Autoimmunity in AML

Research
Scientists – Inflammatory Skin Diseases

Senior
Scientific Researcher – Immunology Discovery

Tier 2 Canada Research Chair – Immunology and Inflammation

Research
Positions – Cancer and Immunotherapy

> See All Jobs