Immune Regulation News Volume 12.45 | Nov 27 2020

May 12, 2022

IRN 12.45 | Nov 27 2020

Immune Regulation News by STEMCELL Technologies

Vol. 12.45 – 27 November, 2020

TOP STORY

MEK Inhibition Reprograms CD8⁺
T Lymphocytes into Memory Stem Cells with Potent Antitumor Effects

Scientists found that MEK1/2 inhibition induced stem cell–like memory T cells that had naive phenotype with self-renewability, enhanced multipotency and proliferative capacity.
[Nature Immunology]

Full Article

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PUBLICATIONSRanked by the impact factor of the journal

Bacterial
Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition

Investigators report the development of genetically engineered outer membrane vesicles whose surface has been modified by insertion of the ectodomain of programmed death 1.
[ACS Nano]

Full Article Graphical
Abstract

Functional
Compensation Precedes Recovery of Tissue Mass following Acute Liver Injury

The authors identified a new phase of functional compensation following acute liver injury that occurs prior to cellular proliferation.
[Nature Communications]

Full Article

Bispecific
Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury

CD34‐CD42b platelet‐targeting bispecific antibodies were designed to simultaneously recognize HSCs and platelets. After inhalation delivery, PT‐BsAbs reached the lungs and conjoined HSCs and platelets.
[Advanced Science]

Full Article

The
E3 Ubiquitin Ligase Peli1 Regulates the Metabolic Actions of mTORC1 to Suppress Antitumor T Cell Responses

Researchers identified the E3 ubiquitin ligase Peli1 as an important regulator of T cell metabolism and antitumor immunity. Peli1 ablation profoundly promotes tumor rejection, associated with increased tumor‐infiltrating CD4 and CD8 T cells.
[EMBO Journal]

Abstract Graphical Abstract

High-Dose
per Fraction Radiotherapy Induces Both Anti-Tumor Immunity and Immunosuppressive Responses in Prostate Tumors

Scientists studied the effects of high-dose per fraction radiotherapy with and without anti-Gr-1 using syngeneic murine allograft prostate cancer models. The dynamic change of immune populations, including tumor-infiltrating lymphocytes, T-regulatory cells, and myeloid-derived suppressive cells was evaluated using flow cytometry and immunohistochemistry.
[Clinical Cancer Research]

Abstract

Inflammasomes
within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity

Investigators report that hyperactive DCs have an enhanced ability to migrate to draining lymph nodes and stimulate potent cytotoxic T lymphocyte responses.
[Cell Reports]

Full Article

The
SUMOylation of TAB2 Mediated by TRIM60 Inhibits MAPK/NF-κB Activation and the Innate Immune Response

Deficiency of TRIM60 in macrophages led to enhanced MAPK and NF-κB activation, accompanied by elevated levels of proinflammatory cytokines but not IFN-I.
[Cellular & Molecular Immunology]

Full Article

Loss
of Interleukin-17 Receptor D Promotes Chronic Inflammation-Associated Tumorigenesis

The authors showed that genetic disruption of interleukin-17 receptor D (Il17rd) led to the increased formation of spontaneous tumors in multiple tissues of aging mice. Loss of IL-17RD also promoted tumor development in a model of colitis-associated colorectal cancer, associated with an exacerbated inflammatory response.
[Oncogene]

Abstract

Amphiphilic
Polyelectrolyte Graft Copolymers Enhance the Activity of Cyclic Dinucleotide STING Agonists

Scientists demonstrated that a lead cyclic dinucleotide carrier formulation can enhance stimulator of interferon gene activation in vivo in a model of intratumoral immunotherapy.
[Advanced Healthcare Materials]

Abstract

Melanoma
Cells Can Be Eliminated by Sialylated CD43 × CD3 Bispecific T Cell Engager Formats In Vitro and In
Vivo

To increase the efficacy of AT1413 as a therapeutic antibody, researchers generated two different formats of bispecific T-cell engaging antibodies to both CD43s and CD3ε.
[Cancer Immunology Immunotherapy]

Abstract

The
Immuno-Reactivity of Polypseudorotaxane Functionalized Magnetic CDMNP-PEG-CD Nanoparticles

Nanoparticles were assessed in vivo for retention, bio-distribution and immunoreactivity. Cyclodextrin molecules via polyethylene glycol induced a temporary blood monocyte response and was cleared effectively from the body through the urine system in mice.
[Journal of Cellular and Molecular Medicine]

Full Article

New human primary cell products—frozen leukopaks, regulatory T cells, and more. Click to view products.

REVIEWS

Modification of Proteins by Metabolites in Immunity

Scientists review the recent findings in post-translational modifications in macrophages and T cells and speculate whether they could be of use in the effort to develop therapeutics for immune-related diseases.
[Immunity]

Abstract

Regulatory T Cell Therapy following Liver Transplantation

The authors summarize the discovery and development of Tregs, and discuss the outstanding challenges of Treg cell therapy and its future prospects for routine use in liver transplantation.
[Liver Transplantation]

Abstract

INDUSTRY AND POLICY NEWS

7
^th L’Oréal-UNESCO for Women in Science Middle East Regional Young Talents Program Recognizes Six Exceptional Female Scientists from the GCC

The L’Oréal-UNESCO For Women in Science Middle East Regional Young Talents Program, in partnership with Khalifa University of Science and Technology, awarded six winners in the Post-doctorate Researchers and PhD Students categories where Dr. Lama AlAbdi (KSA), Dr. Isra Marei (Qatar), and Dr. Maryam Tariq Khaleel Alhashmi (UAE) each received EUR20,000 in the Post-doctorate Researchers category.
[L’Oréal-UNESCO (Business Today)]

Press Release

FEATURED EVENT

MEK Inhibition Reprograms CD8⁺
T Lymphocytes into Memory Stem Cells with Potent Antitumor Effects

Bacterial
Outer Membrane Vesicles Presenting Programmed Death 1 for Improved Cancer Immunotherapy via Immune Activation and Checkpoint Inhibition

Functional
Compensation Precedes Recovery of Tissue Mass following Acute Liver Injury

Bispecific
Antibody Inhalation Therapy for Redirecting Stem Cells from the Lungs to Repair Heart Injury

The
E3 Ubiquitin Ligase Peli1 Regulates the Metabolic Actions of mTORC1 to Suppress Antitumor T Cell Responses

High-Dose
per Fraction Radiotherapy Induces Both Anti-Tumor Immunity and Immunosuppressive Responses in Prostate Tumors

Inflammasomes
within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity

The
SUMOylation of TAB2 Mediated by TRIM60 Inhibits MAPK/NF-κB Activation and the Innate Immune Response

Loss
of Interleukin-17 Receptor D Promotes Chronic Inflammation-Associated Tumorigenesis

Amphiphilic
Polyelectrolyte Graft Copolymers Enhance the Activity of Cyclic Dinucleotide STING Agonists

Melanoma
Cells Can Be Eliminated by Sialylated CD43 × CD3 Bispecific T Cell Engager Formats In Vitro and In
Vivo

The
Immuno-Reactivity of Polypseudorotaxane Functionalized Magnetic CDMNP-PEG-CD Nanoparticles

Modification of Proteins by Metabolites in Immunity

Regulatory T Cell Therapy following Liver Transplantation

7
^th L’Oréal-UNESCO for Women in Science Middle East Regional Young Talents Program Recognizes Six Exceptional Female Scientists from the GCC

SfN Global Connectome

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Scientific Researcher – Immunology Discovery

Tier 2 Canada Research Chair – Immunology and Inflammation

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Positions – Cancer and Immunotherapy

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