Immune Regulation News Volume 12.46 | Dec 4 2020

May 12, 2022

140

IRN 12.46 | Dec 4 2020

Immune Regulation News by STEMCELL Technologies

Vol. 12.46 – 4 December, 2020

TOP STORY

Targeting
PAK4 to Reprogram the Vascular Microenvironment and Improve CAR-T Immunotherapy for Glioblastoma

p21-activated kinase 4 (PAK4) knockout induced adhesion protein re-expression in endothelial cells, reduced vascular abnormalities, improved T cell infiltration and inhibits glioblastoma growth in mice.
[Nature Cancer]

Abstract Press Release

Request your free copy of the 'Human Immune Cytokines' Wallchart

PUBLICATIONSRanked by the impact factor of the journal

Neuroblast
Senescence in the Aged Brain Augments Natural Kill Cell Cytotoxicity Leading to Impaired Neurogenesis and Cognition

Investigators report that natural killer cells of the innate immune system reside in the dentate gyrus neurogenic niche of aged brains in humans and mice.
[Nature Neuroscience]

Abstract

CCL7
Recruits cDC1 to Promote Antitumor Immunity and Facilitate Checkpoint Immunotherapy to Non-Small Cell Lung Cancer

Researchers demonstrated that CCL7 facilitates anti-PD-1 therapy for the Kras^LSL−G12D/+Tp53^fl/fl and the Kras^LSL−G12D/+Lkb1^fl/fl non-small cell lung cancer mouse models by recruiting conventional DC 1 (cDC1) into the tumor microenvironment to promote T cell expansion.
[Nature Communications]

Full Article

Multiplexed
CRISPR/CAS9-Mediated Engineering of Pre-Clinical Mouse Models Bearing Native Human B Cell Receptors

The authors report a one‐step CRISPR/Cas9 knock-in methodology to combine the insertion of human germline immunoglobulin heavy and light chains at their endogenous loci in mice.
[EMBO Journal]

Full Article Graphical Abstract

Axl
and Mertk Receptors Cooperate to Promote Breast Cancer Progression by Combined Oncogenic Signaling and Evasion of Host Anti-Tumor Immunity

Scientists ablated Axl on tumor cells using CRISPR/Cas9 gene editing, and by targeting Mertk in the tumor microenvironment, they observed distinct functions of TAM as oncogenic kinases as well as inhibitory immune receptors.
[Cancer Research]

Abstract

Therapeutic
Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis

Using genetically modified mouse models of spontaneous colorectal and lung cancers, researchers found that Metadherin promotes cancer progression by facilitating Wnt activation and by inducing cytotoxic T cell exhaustion, respectively.
[Cancer Research]

Abstract

Multi-Modal
Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis

Investigators analyzed compositional and transcriptional changes of the brain immune landscape in response to aging and gut dysbiosis.
[Cell Reports]

Full Article Graphical Abstract

Pik3c3
Deficiency in Myeloid Cells Imparts Partial Resistance to Experimental Autoimmune Encephalomyelitis Associated with Reduced IL-1β Production

Scientists investigated the role of PIK3C3 in myeloid cell biology using myeloid cell-specific Pik3c3-deficient mice.
[Cellular & Molecular Immunology]

Abstract

LncRNA
lncLy6C Induced by Microbiota Metabolite Butyrate Promotes Differentiation of Ly6C^high to Ly6C^int/neg Macrophages through lncLy6C/C/EBPβ/Nr4A1 Axis

Researchers found that lncLy6C, a novel ultraconserved lncRNA, promoted differentiation of Ly6C^high inflammatory monocytes into Ly6C^low/neg resident macrophages.
[Cell Discovery]

Full Article

Beyond
Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice

Immune profiling results revealed unique immune diversity following each experimental condition, suggesting each stressor results in distinct circulating immune responses, with clear consequences for deep spaceflight.
[iScience]

Full Article Graphical Abstract

New human primary cell products—frozen leukopaks, regulatory T cells, and more. Click to view products.

REVIEWS

Succinate
Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation

The authors explored the main cellular pathways regulated by the succinate–SUCNR1 axis and focus on the biology of SUCNR1 and its roles influencing the function of myeloid cells.
[Trends in Immunology]

Abstract

Detection of Immunogenic Cell Death and Its Relevance for Cancer Therapy

Scientists outline methodological approaches for measuring immunogenic cell death markers in vitro and ex vivo for the discovery of next-generation antineoplastic agents, the development of personalized anticancer regimens, and the identification of optimal therapeutic combinations for the clinical management of cancer.
[Cell Death & Disease]

Full Article

INDUSTRY AND POLICY NEWS

Turnstone Biologics Announces First Patients Enrolled in Phase I/II Clinical Trial Evaluating RIVAL-01 for the Treatment of Solid Tumors

Turnstone Biologics Corp., have enrolled the first patients in a Phase I/IIa clinical trial of its RIVAL-01/TAK-605 candidate in patients with solid tumors, conducted in collaboration with Takeda Pharmaceutical Company Limited. RIVAL-01 consists of Turnstone’s proprietary oncolytic vaccinia virus backbone encoding transgenes for Flt3 ligand, anti-CTLA-4 antibody and IL-12 cytokine, purposefully designed to work together to drive immune activity and re-program the microenvironment to be best suited for tumor eradication.
[Turnstone Biologics Corp. (Businesswire, Inc.)]

Press Release

European
Commission Approves Janssen’s TREMFYA^®▼ (Guselkumab), a First-in-Class Treatment for Active Psoriatic Arthritis (PsA)

The Janssen Pharmaceutical Companies of Johnson & Johnson announced that the European Commission has approved TREMFYA^®▼ for the treatment of adult patients with active psoriatic arthritis who have had an inadequate response or who have been intolerant to a prior disease-modifying antirheumatic drug therapy.
[Janssen Global Services, LLC]

Press Release

FEATURED EVENT

Targeting
PAK4 to Reprogram the Vascular Microenvironment and Improve CAR-T Immunotherapy for Glioblastoma

Neuroblast
Senescence in the Aged Brain Augments Natural Kill Cell Cytotoxicity Leading to Impaired Neurogenesis and Cognition

CCL7
Recruits cDC1 to Promote Antitumor Immunity and Facilitate Checkpoint Immunotherapy to Non-Small Cell Lung Cancer

Multiplexed
CRISPR/CAS9-Mediated Engineering of Pre-Clinical Mouse Models Bearing Native Human B Cell Receptors

Axl
and Mertk Receptors Cooperate to Promote Breast Cancer Progression by Combined Oncogenic Signaling and Evasion of Host Anti-Tumor Immunity

Therapeutic
Targeting of Metadherin Suppresses Colorectal and Lung Cancer Progression and Metastasis

Multi-Modal
Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis

Pik3c3
Deficiency in Myeloid Cells Imparts Partial Resistance to Experimental Autoimmune Encephalomyelitis Associated with Reduced IL-1β Production

LncRNA
lncLy6C Induced by Microbiota Metabolite Butyrate Promotes Differentiation of Ly6C^high to Ly6C^int/neg Macrophages through lncLy6C/C/EBPβ/Nr4A1 Axis

Beyond
Low-Earth Orbit: Characterizing Immune and microRNA Differentials following Simulated Deep Spaceflight Conditions in Mice

Succinate
Receptor 1: An Emerging Regulator of Myeloid Cell Function in Inflammation

Detection of Immunogenic Cell Death and Its Relevance for Cancer Therapy

Turnstone Biologics Announces First Patients Enrolled in Phase I/II Clinical Trial Evaluating RIVAL-01 for the Treatment of Solid Tumors

European
Commission Approves Janssen’s TREMFYA^®▼ (Guselkumab), a First-in-Class Treatment for Active Psoriatic Arthritis (PsA)

Keystone
Symposia: Innate Immunity: Mechanisms and Modulation

> See All Events

Postdoctoral Fellow – Neuroinflammation Research

Scientist – Autoimmunity in AML

Senior
Scientific Researcher – Immunology Discovery

Tier 2 Canada Research Chair – Immunology and Inflammation

Postdoctoral Fellow – Cancer Immunology and Immunotherapy

> See All Jobs