 | | Vol. 12.48 – 18 December, 2020 |
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| Researchers demonstrated that macrophages were the predominant infiltrating immune cell type in breast cancer susceptibility (BRCA)-associated triple-negative breast cancer.
[Nature Cancer] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using high-resolution imaging, viral tracing, single-cell transcriptomics, and optogenetics, investigators identified and functionally tested a sensory neuro-immune circuit that was responsive to lymph-borne inflammatory signals.
[Cell] |
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| Scientists showed that combining a type II RAFi with an allosteric MEKi durably prevented and overcame acquired resistance among cancers with KRAS, NRAS, NF1, BRAFnon-V600 and BRAFV600 mutations.
[Cancer Discovery] |
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| Focusing on macrophages in the brain, researchers established a binary transgenic system involving complementation-competent NCre and CCre fragments whose expression was driven by distinct promoters.
[Immunity] |
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| The authors report that loss of receptor activator of nuclear factor-κB (RANK) signaling in mouse tumor cells increased leukocytes, lymphocytes, and CD8+ T cells, and reduced macrophage and neutrophil infiltration.
[Nature Communications] |
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| Researchers investigated the tumor-suppressive role of E74-like factor 3 (ELF3) in bile duct cells by identifying several previously unknown direct target genes of ELF3 that appeared to be implicated in biliary duct carcinogenesis.
[Cancer Research] |
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| Scientists developed a high-throughput in vitro pharmacologic screening platform and used it to measure the cell type–specific sensitivities of activated CD8+ T cells and B16 melanoma cells to a wide array of metabolic perturbations during antigen-specific killing of cancer cells by CD8+ T cells.
[Cancer Immunology Research] |
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| Reinfusion of the engineered neutrophils into 4T1 tumor-bearing mice led to more Ce6 accumulation in tumors relative to Ce6 nanoformulation.
[Cell Reports] |
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| To elucidate the mechanisms of oral immunotherapy (OIT), especially during the immunological transition from desensitization to allergy regulation, researchers generated a clinical OIT murine model and used it to examine immunological events of OIT.
[Mucosal Immunology] |
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| Researchers characterized a new human tumor necrosis factor receptor 2 (TNFR2)-directed antibody agonist isolated from mice. They found that the antibody agonist expanded the number of Treg cells within cultures of primary human CD4+ T cells from healthy donors and patients with type 1 diabetes or Sézary syndrome.
[Science Signaling] |
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| The authors found that inhibiting the function of the TRPM7 chanzyme potentiated the thymic development of Treg cells in mice and led to a substantially higher frequency of functional Treg cells in the periphery.
[Science Signaling] |
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| Investigators tested inhibitors of cap-dependent mRNA translation for the ability to sensitise diffuse large B-cell lymphoma and mantle cell lymphoma cells to apoptosis by venetoclax.
[British Journal of Cancer] |
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| Scientists showed that the Wnt family was extensively upregulated in and impacted the prognosis of patients with prostate adenocarcinoma and bladder urothelial carcinoma. Moreover, the Wnt family correlated with the levels of infiltrating immune cells, including B cells, CD4+ T cells, CD8+ T cells, neutrophils, macrophages, and dendritic cells.
[Cancer Gene Therapy] |
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| Investigators summarize recent insights revealing the role of reactive oxygen species and the differential requirement of the main cellular antioxidant pathways, including the components of the thioredoxin and glutathione pathways, as well as their transcriptional regulator NF-E2-related factor 2, for proliferation, survival and function of T cells, B cells and macrophages.
[Nature Reviews Immunology] |
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| The authors review the gut microbiota, liver immunology, and the interaction between the gut and liver.
[Cellular & Molecular Immunology] |
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| Scientists focus on the roles of antigen presenting cells (APCs) in the generation and function of Tregs in humans. In addition to stimulating the development of Tregs, APCs activate Tregs and provide signals that induce specialised functional and homing marker expression.
[European Journal of Immunology] |
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| Arbutus Biopharma Corporation announced additional clinical data from an ongoing Phase Ia/Ib clinical trial with AB-729, its proprietary GalNAc delivered RNAi compound.
[Arbutus Biopharma Corporation] |
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| Cabaletta Bio, Inc. announced that the first patient has been dosed in the DesCAARTesâ„¢ Phase I clinical trial of DSG3-CAART for the treatment of patients with mucosal-dominant pemphigus vulgaris.
[Cabaletta Bio, Inc. (GlobeNewswire, Inc.)] |
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| January 7 – 8, 2021
Virtual |
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| | University of Florida – Gainesville, Florida, United States |
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| | Lerner Research Institute, Cleveland Clinic – Cleveland, Ohio, United States |
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| | Karolinska Institutet – Solna, Sweden |
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| | Rubius Therapeutics – Cambridge, Massachusetts, United States |
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| | Queen’s University – Kingston, Ontario, Canada |
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