Immune Regulation News Volume 13.00 | Jan 8 2021

May 12, 2022

113

IRN 13.00 | Jan 8 2021

Immune Regulation News by STEMCELL Technologies

Vol. 13.00 – 8 January, 2021

TOP STORY

Gut-Licensed IFNγ⁺ NK Cells Drive LAMP1⁺TRAIL⁺
Anti-Inflammatory Astrocytes

Using high-throughput flow cytometry screening, single-cell RNA sequencing and CRISPR–Cas9-based cell-specific in vivo genetic perturbations in mice, researchers identified a subset of astrocytes that expressed the lysosomal protein LAMP12 and the death receptor ligand TRAIL.
[Nature]

Abstract

Explore scientific events this January with the Science Events Calendar.

PUBLICATIONSRanked by the impact factor of the journal

Mechanism of EBV Inducing Anti-Tumor Immunity and Its Therapeutic Use

Researchers showed that expression of the Epstein–Barr virus signaling protein LMP1 in B cells provoked T cell responses to multiple tumor-associated antigens.
[Nature]

Abstract

Integrin
αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer

The authors identified the SOX4 transcription factor as an important resistance mechanism to T cell-mediated cytotoxicity for triple negative breast cancer cells.
[Cancer Cell]

Abstract Graphical Abstract

The
Persistence of Interleukin-6 Is Regulated by a Blood Buffer System Derived from Dendritic Cells

Scientists found that conventional dendritic cells, defined in mice via expression of the transcription factor Zbtb46, were a major source of circulating sIL-6R and, thus, systemically regulated IL-6 signaling.
[Immunity]

Full Article Graphical Abstract

Distinct
Developmental Pathways from Blood Monocytes Generate Human Lung Macrophage Diversity

Intravascular cell labeling, cell transplantation, and fate-mapping studies established that classical CD14⁺ blood monocytes derived from ematopoietic stem and progenitor cells migrated into lung tissue and gave rise to human interstitial and alveolar macrophages.
[Immunity]

Abstract Graphical Abstract

Intracellular
Immune Sensing Promotes Inflammation via Gasdermin D–Driven Release of a Lectin Alarmin

Scientists revealed that cytosolic lipopolysaccharide sensing triggered the release of galectin-1, a β-galactoside-binding lectin. They also found increased galectin-1 in sera from human patients with sepsis.
[Nature Immunology]

Abstract

Mitochondrial
Stress Induced by Continuous Stimulation Under Hypoxia Rapidly Drives T Cell Exhaustion

In vitro, although CD8⁺ T cells experiencing continuous stimulation or hypoxia alone differentiated into functional effectors, the combination rapidly drove T cell dysfunction consistent with exhaustion.
[Nature Immunology]

Abstract

An
IL-2-Grafted Antibody Immunotherapy with Potent Efficacy against Metastatic Cancer

Investigators present a second-generation CD122-biased interleukin-2 (IL-2), developed by splitting and permanently grafting unmutated human IL-2 (hIL-2) to its antigen-binding groove on the anti-hIL-2 monoclonal antibody NARA1, thereby generating NARA1leukin.
[Nature Communications]

Full Article

Therapeutic
Anti-Glioma Effect of the Combined Action of PCSK Inhibitor with the Anti-Tumoral Factors Secreted by Poly (I:C)-Stimulated Macrophages

Scientists developed a new therapeutic strategy to switch macrophages phenotype and reactivate their anti-tumoral functions. They showed a dual activity of a proprotein convertases inhibitor as anti-glioma drug and anti-tumoral macrophages’ reactivation drug.
[Cancer Gene Therapy]

Full Article

Extracellular
Vesicles Derived from miR-199a-5p-Modified Adipose-Derived Mesenchymal Stem Cells Alleviate Immune Thrombocytopenia by Inhibiting T Helper 17 Differentiation

Researchers investigated the role of miR-199a-5p in T helper 17 (Th17) differentiation and determined whether extracellular vesicles derived from miR-199a-5p-modified adipose-derived MSCs could relieve immune thrombocytopenia by inhibiting Th17 differentiation.
[Laboratory Investigation]

Abstract

Use ImmunoCult™ to differentiate mouse CD4+ cells to Tregs.

REVIEWS

NAD⁺ Metabolism, Stemness, the Immune Response, and Cancer

The authors review the role of NAD⁺ and NAMPT in the ways that they may influence cancer metabolism, the immune system, stemness, aging, and cancer. They also review some ongoing research on therapeutic approaches.
[Signal Transduction and Targeted Therapy]

Full Article

Emerging
Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer Immunotherapy

Scientists reveal the development of a highly promising therapeutic approach for cancer immunotherapy by targeting PD-1/PD-L1 ubiquitination.
[Molecular Therapy]

Abstract Graphical Abstract

INDUSTRY AND POLICY NEWS

Genentech’s
Novel Anti-TIGIT Tiragolumab Granted FDA Breakthrough Therapy Designation in Combination with Tecentriq for PD-L1-High Non-Small Cell Lung Cancer

Genentech announced that tiragolumab, a novel cancer immunotherapy designed to bind to TIGIT, has been granted Breakthrough Therapy Designation by the FDA, in combination with Tecentriq^® for the first-line treatment of people with metastatic non-small cell lung cancer whose tumors have high PD-L1 expression with no EGFR or ALK genomic tumor aberrations.
[Genentech]

Press Release

FEATURED EVENT

Gut-Licensed IFNγ⁺ NK Cells Drive LAMP1⁺TRAIL⁺
Anti-Inflammatory Astrocytes

Mechanism of EBV Inducing Anti-Tumor Immunity and Its Therapeutic Use

Integrin
αvβ6–TGFβ–SOX4 Pathway Drives Immune Evasion in Triple-Negative Breast Cancer

The
Persistence of Interleukin-6 Is Regulated by a Blood Buffer System Derived from Dendritic Cells

Distinct
Developmental Pathways from Blood Monocytes Generate Human Lung Macrophage Diversity

Intracellular
Immune Sensing Promotes Inflammation via Gasdermin D–Driven Release of a Lectin Alarmin

Mitochondrial
Stress Induced by Continuous Stimulation Under Hypoxia Rapidly Drives T Cell Exhaustion

An
IL-2-Grafted Antibody Immunotherapy with Potent Efficacy against Metastatic Cancer

Therapeutic
Anti-Glioma Effect of the Combined Action of PCSK Inhibitor with the Anti-Tumoral Factors Secreted by Poly (I:C)-Stimulated Macrophages

Extracellular
Vesicles Derived from miR-199a-5p-Modified Adipose-Derived Mesenchymal Stem Cells Alleviate Immune Thrombocytopenia by Inhibiting T Helper 17 Differentiation

NAD⁺ Metabolism, Stemness, the Immune Response, and Cancer

Emerging
Role of Ubiquitination in the Regulation of PD-1/PD-L1 in Cancer Immunotherapy

Genentech’s
Novel Anti-TIGIT Tiragolumab Granted FDA Breakthrough Therapy Designation in Combination with Tecentriq for PD-L1-High Non-Small Cell Lung Cancer

Integrating Metabolism and Immunity

> See All Events

Postdoctoral
Associate – Tumor Immune Microenvironment

Research Scientist – Tumor Microenvironment

Postoctoral
Fellow – Neuroimmunology

Lab
Coordinator – Breast Cancer Immunology

Postdoctoral Fellow – Breast Cancer Immuno-Oncology Research

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