Immune Regulation News Volume 13.01 | Jan 15 2021

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    IRN 13.01 | Jan 15 2021


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.01 – 15 January, 2021
    TOP STORY

    A
    Noninflammatory mRNA Vaccine for Treatment of Experimental Autoimmune Encephalomyelitis

    Scientists showed that systemic delivery of nanoparticle-formulated 1 methylpseudouridine-modified messenger RNA coding for disease-related autoantigens results in antigen presentation on splenic CD11c+ antigen-presenting cells in the absence of costimulatory signals.
    [Science]

    Abstract

    New human primary cell products—frozen leukopaks, regulatory T cells, and more. Click to view products.
    PUBLICATIONSRanked by the impact factor of the journal

    RORα
    Is a Critical Checkpoint for T Cell and ILC2 Commitment in the Embryonic Thymus

    The authors demonstrated that functional innate lymphoid cells cells could arise in the embryonic thymus from shared T cell precursors, preceding the emergence of CD4+CD8+ T cells.
    [Nature Immunology]

    Abstract

    NF-κB-Inducing
    Kinase Maintains T Cell Metabolic Fitness in Antitumor Immunity

    Researchers showed that deficiency in NF-κB-inducing kinase impaired glycolysis induction, rendering CD8+ effector T cells hypofunctional in the tumor microenvironment.
    [Nature Immunology]

    Abstract

    Critical
    Role of Synovial Tissue–Resident Macrophage Niche in Joint Homeostasis and Suppression of Chronic Inflammation

    During synovial tissue homeostasis, both monocyte-derived F4/80int and self-renewing F4/80hi tissue–resident, macrophage populations were identified.
    [Science Advances]

    Full Article

    Identification
    of a Subset of Immunosuppressive P2RX1-Negative Neutrophils in Pancreatic Cancer Liver Metastasis

    RNA sequencing of murine PDAC liver metastasis-infiltrated neutrophils show that P2RX1-deficient neutrophils express increased levels of immunosuppressive molecules, including PD-L1, and have enhanced mitochondrial metabolism.
    [Nature Communications]

    Full Article

    DsbA-L
    Deficiency in T Cells Promotes Diet-Induced Thermogenesis through Suppressing IFN-γ Production

    Researchers showed that high-fat diet feeding greatly suppressed the expression of disulfide-bond A oxidoreductase-like protein (DsbA-L), a mitochondria-localized chaperone protein, in adipose-resident T cells, which correlated with reduced T cell mitochondrial function.
    [Nature Communications]

    Full Article

    E7386,
    a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling

    E7386 demonstrated clear antitumor activity via modulation of the Wnt/β-catenin signal pathway and alteration of the tumor and immune microenvironments, and its antitumor activity could be enhanced in combination with anti-PD-1 antibody.
    [Cancer Research]

    Abstract

    Efficient
    IL-2R Signaling Differentially Affects the Stability, Function, and Composition of the Regulatory T-Cell Pool

    Investigators characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25, the α-chain of IL-2R, which resulted in diminished receptor expression and reduced IL-2R signaling.
    [Cellular & Molecular Immunology]

    Full Article

    Toll-Like
    Receptor 7 Deficiency Suppresses Type 1 Diabetes Development by Modulating B-Cell Differentiation and Function

    Scientists discovered that Tlr7-deficient nonobese diabetic (NOD) mice, a model of human type 1 diabetes, exhibited a significantly delayed onset and reduced incidence of type 1 diabetes compared with Tlr7-sufficient NOD mice. Mechanistic investigations showed that Tlr7 deficiency significantly altered B-cell differentiation and immunoglobulin production.
    [Cellular & Molecular Immunology]

    Full Article

    Histone
    Methyltransferase DOT1L Controls State-Specific Identity during B Cell Differentiation

    The authors identified a role for the histone H3K79 methyltransferase DOT1L in controlling B‐cell differentiation. Mouse B cells lacking Dot1L failed to establish germinal centers and normal humoral immune responses in vivo.
    [EMBO Reports]

    Full ArticleGraphical Abstract

    Intestinal-Derived
    ILCs Migrating in Lymph Increase IFNγ Production in Response to Salmonella Typhimurium Infection

    Researchers enumerated the intestinal lymph innate lymphoid cells (ILCs) that traffic from the intestine to the mesenteric lymph nodes. They provide a detailed characterisation of these lymph-migratory ILCs.
    [Mucosal Immunology]

    Full Article

    Reparative
    System Arising from CCR2(+) Monocyte Conversion Attenuates Neuroinflammation following Ischemic Stroke

    Scientists found that CCR2highCX3CR1low monocytes recruited to the injured brain were cytokine-dependently converted into CCR2lowCX3CR1high macrophages, especially under the influence of IL-4 and IL-13, thereby attenuating the neuroinflammation following sterile ischemic stroke.
    [Translational Stroke Research]

    Full Article

    Enhanced
    BCR Signaling Inflicts Early Plasmablast and Germinal Centre B Cell Death

    Although immunization with T-dependent antigens increased B-cell receptor signaling, it led to plasma cells reduction and increased apoptosis. Dependent on the antigen, the early germinal centre B cell response was equally reduced and apoptosis increased.
    [iScience]

    AbstractGraphical Abstract

    Request a copy of the COVID-19 wallchart.
    REVIEWS

    Beyond
    Conventional Immune-Checkpoint Inhibition — Novel Immunotherapies for Renal Cell Carcinoma

    Using the structure provided by the well-described cancer–immunity cycle, scientists outline the key steps required for a successful antitumor immune response in the context of renal cell carcinoma, and describe the development of promising new immunotherapies within the context of this framework.
    [Nature Reviews Clinical Oncology]

    Abstract

    The Thymus and the Science of Self

    The author discusses the evidence that the thymus serves as a unique lymphoid organ able to instruct T cells to recognize and be tolerant to harmless self before adopting the capacity to defend the body against potentially injurious non-self-antigens presented in the context of different challenges from infections to exposure to malignant cells.
    [Seminars in Immunopathology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Boehringer Ingelheim and Enara Bio Enter Strategic Collaboration and Licensing Agreement to Discover Novel Shared Antigens for Cancer Immunotherapies

    Boehringer Ingelheim and Enara Bio, announced that they have entered into a strategic collaboration and licensing agreement to research and develop novel targeted cancer immunotherapies, leveraging Enara Bio’s Dark Antigen™ discovery platform.
    [Boehringer Ingelheim (BusinessWire, Inc.)]

    Press Release

    FEATURED EVENT

    Neuroimmune
    Models for Alzheimer’s Risk

    January 26, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral
    Fellow Positions – Breast and Ovarian Immuno-Oncology

    The Medical College of Wisconsin – Milwaukee, Wisconsin, United States

    Postdoctoral
    Associate – Tumor Immune Microenvironment

    University of Florida – Gainesville, Florida, United States

    Postdoctoral Fellow – Breast Cancer Immuno-Oncology Research

    Salk Institute of Biological Studies – La Jolla, California, United States

    Lab Coordinator – Breast Cancer Immunology

    Salk Institute of Biological Studies – La Jolla, California, United States

    Research Scientist – Tumor Microenvironment

    Systimmune, Inc. – Redmond, Washington, United States

    > See All Jobs

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