Immune Regulation News Volume 13.02 | Jan 22 2021

May 12, 2022

IRN 13.02 | Jan 22 2021

Immune Regulation News by STEMCELL Technologies

Vol. 13.02 – 22 January, 2021

TOP STORY

FYN–TRAF3IP2 Induces NF-κB Signaling-Driven Peripheral T-Cell Lymphoma

Consistent with a driver oncogenic role, FYN–TRAF3IP2 expression in hematopoietic progenitors induced NF-κB-driven T-cell transformation in mice and cooperated with loss of the Tet2 tumor suppressor in peripheral T-cell lymphoma development.
[Nature Cancer]

Abstract

Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality

PUBLICATIONSRanked by the impact factor of the journal

Restoring Metabolism of Myeloid Cells Reverses Cognitive Decline in Aging

Scientists showed that in aging mice myeloid cell bioenergetics were suppressed in response to increased signaling by the lipid messenger prostaglandin E2, a major modulator of inflammation.
[Nature]

Abstract Press Release

Cathepsin
C Promotes Breast Cancer Lung Metastasis by Modulating Neutrophil Infiltration and Neutrophil Extracellular Trap Formation

Researchers showed that tumor-secreted protease cathepsin C promoted breast-to-lung metastasis by regulating recruitment of neutrophils and formation of neutrophil extracellular traps.
[Cancer Cell]

Full Article Graphical Abstract

Isolevuglandin-Modified Cardiac Proteins Drive CD4⁺
T Cell Activation in the Heart and Promote Cardiac Dysfunction

Investigators discovered that T cell receptor antigen recognition increased in the left ventricle as cardiac dysfunction progressed.
[Circulation]

Abstract

Gut CD4⁺
T Cell Phenotypes Are a Continuum Molded by Microbes, Not by TH Archetypes

To determine the states that CD4⁺ effector lymphocytes (T_eff) cells actually adopt in frontline tissues in vivo, scientists applied single-cell transcriptome and chromatin analyses to colonic T_eff cells in germ-free or conventional mice.
[Nature Immunology]

Abstract

Distinct
Metabolic Programs Established in the Thymus Control Effector Functions of γδ T Cell Subsets in Tumor Microenvironments

The authors found that γδ T cell subsets making either interferon-γ or interleukin-17 had intrinsically distinct metabolic requirements.
[Nature Immunology]

Full Article

Spatiotemporal
Single-Cell Profiling Reveals That Invasive and Tissue-Resident Memory Donor CD8⁺
T Cells Drive Gastrointestinal Acute Graft-Versus-Host Disease

Researchers combined the serial intravascular staining technique with single-cell RNA sequencing to dissect the tightly connected processes by which donor T cells initially infiltrate tissues and then established a pathogenic tissue residency program in a rhesus macaque allo-HCT model that develops acute graft-versus-host disease.
[Science Translational Medicine]

Abstract

Substrate-Specific
Recognition of IKKs Mediated by USP16 Facilitates Autoimmune Inflammation

Investigators found that IKKβ ubiquitination on lysine-238 was substantially increased during inflammation. Using mass spectrometry, they identified USP16 as an essential regulator of the IKKβ ubiquitination level that selectively affected p105 phosphorylation without directly affecting p65 or IκBα phosphorylation.
[Science Advances]

Full Article

Enoxacin
Upregulates microRNA Biogenesis and Downregulates Cytotoxic CD8 T Cell Function in Autoimmune Cholangitis

Scientists showed that liver‐infiltrating dnTGFβRII CD8 T cells had significantly decreased levels of the miRNA biogenesis molecules P4ha1 and Ago2 along with significantly increased levels of granzyme B and perforin.
[Hepatology]

Abstract

SOX-5
Activates a Novel RORγt Enhancer To Facilitate Experimental Autoimmune Encephalomyelitis by Promoting Th17 Cell Differentiation

The authors identified a novel enhancer of RORγt gene in Th17 cells, RORCE2. RORCE2 deficiency suppressed RORγt expression and Th17 differentiation, leading to reduced severity of experimental autoimmune encephalomyelitis.
[Nature Communications]

Full Article

mTORC1
and mTORC2 Coordinate Early NK Cell Development by Differentially Inducing E4BP4 and T-Bet

Researchers developed two methods to inactivate mTOR, Raptor, or Rictor in early stage natural killer (NK) cells or in late-stage NK cells. They found that when mTOR was deleted by CD122-Cre during and after NK cell commitment, NK cell development was severely impaired.
[Cell Death & Differentiation]

Abstract

ATG7
Is Dispensable for LC3–PE Conjugation in Thioglycolate-Elicited Mouse Peritoneal Macrophages

Using atg5-deficient and atg7^-/- macrophages, scientists provide evidence that loss of ATG5 but not of ATG7 resulted in LC3-II depletion.
[Autophagy]

Full Article

Watch 'collaborating to accelerate COVID-19 research'

REVIEWS

Targeting
Cancer-Promoting Inflammation — Have Anti-Inflammatory Therapies Come of Age?

The authors review the current clinical advances and experimental findings supporting the utility of an anti-inflammatory approach to the treatment of solid malignancies.
[Nature Reviews Clinical Oncology]

Abstract

Overcoming the Challenges Associated with CD3⁺
T-Cell Redirection in Cancer

Scientists discuss novel approaches to overcome the key challenges associated with CD3⁺ bispecific T-cell redirection in order to achieve an optimal balance of anti-tumor activity and safety.
[British Journal of Cancer]

Abstract

INDUSTRY AND POLICY NEWS

NantKwest,
ImmunityBio Announce Positive Interim Data on Survival Rates in Metastatic Pancreatic Cancer Trials

NantKwest, Inc. and ImmunityBio, Inc. announced early interim results of its PD-L1 t-haNK protocols showing median survival rates more than doubled that of the historic rate in patients with advanced metastatic pancreatic cancer for which no other FDA-approved treatment exists.
[NantKwest, Inc.]

Press Release

FEATURED EVENT

FYN–TRAF3IP2 Induces NF-κB Signaling-Driven Peripheral T-Cell Lymphoma

Restoring Metabolism of Myeloid Cells Reverses Cognitive Decline in Aging

Cathepsin
C Promotes Breast Cancer Lung Metastasis by Modulating Neutrophil Infiltration and Neutrophil Extracellular Trap Formation

Isolevuglandin-Modified Cardiac Proteins Drive CD4⁺
T Cell Activation in the Heart and Promote Cardiac Dysfunction

Gut CD4⁺
T Cell Phenotypes Are a Continuum Molded by Microbes, Not by TH Archetypes

Distinct
Metabolic Programs Established in the Thymus Control Effector Functions of γδ T Cell Subsets in Tumor Microenvironments

Spatiotemporal
Single-Cell Profiling Reveals That Invasive and Tissue-Resident Memory Donor CD8⁺
T Cells Drive Gastrointestinal Acute Graft-Versus-Host Disease

Substrate-Specific
Recognition of IKKs Mediated by USP16 Facilitates Autoimmune Inflammation

Enoxacin
Upregulates microRNA Biogenesis and Downregulates Cytotoxic CD8 T Cell Function in Autoimmune Cholangitis

SOX-5
Activates a Novel RORγt Enhancer To Facilitate Experimental Autoimmune Encephalomyelitis by Promoting Th17 Cell Differentiation

mTORC1
and mTORC2 Coordinate Early NK Cell Development by Differentially Inducing E4BP4 and T-Bet

ATG7
Is Dispensable for LC3–PE Conjugation in Thioglycolate-Elicited Mouse Peritoneal Macrophages

Targeting
Cancer-Promoting Inflammation — Have Anti-Inflammatory Therapies Come of Age?

Overcoming the Challenges Associated with CD3⁺
T-Cell Redirection in Cancer

NantKwest,
ImmunityBio Announce Positive Interim Data on Survival Rates in Metastatic Pancreatic Cancer Trials

Nature
Cafe on Type 2 Immunity: Challenges and Opportunities

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Postdoctoral
Fellow – T Cell Immunology and Transplantation

Postdoctoral
Researcher – Neuroimmunology

Faculty
in Immuno-Oncology

Postdoctoral Fellowships – Cancer Immunology

Postdoctoral
Fellow – Cancer Genetics and Immunology

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