| Vol. 13.03 – 29 January, 2021 |
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| Scientists showed that the DNA-binding inflammasome receptor AIM2 had a T cell-intrinsic and inflammasome-independent role in the function of T regulatory cells. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that hepatic macrophages expressed the primary relaxin receptor, and that, on relaxin binding, they switched from the profibrogenic to the pro-resolution phenotype. [Nature Nanotechnology] |
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| To avoid unwanted immune recognition, the authors designed a lentiviral vector system that allowed selective CRISPR antigen removal from tumor cells. [Immunity] |
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| Scientists demonstrated that mast cell-derived tumor necrosis factor was crucial for neutrophil extravasation to sites of contact hypersensitivity-induced skin inflammation by promoting intraluminal crawling. [Immunity] |
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| Researchers report that expression of this immune-regulator in mouse B-1a cells has a critical function in maintaining self-tolerance by regulating these early-developing B cells that express a repertoire enriched for auto-reactivity. [Nature Communications] |
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| The authors demonstrated the power of high-performance in-depth cytotoxic T lymphocytes analysis by revealing the subpopulation-specific expression of co-inhibitory and co-stimulatory receptor targets of key importance for immunotherapy. [Nature Communications] |
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| Investigators explored the ability of a humanized radiolabeled CD8-targeted minibody to non-invasively quantify tumor-infiltrating CD8+ T cells using positron emission tomography. [Clinical Cancer Research] |
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| To investigate the role of p53 in controlling tumor-immune cell crosstalk, scientists studied murine syngeneic models treated with HDM201, a potent and selective second generation MDM2 inhibitor. [Cancer Research] |
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| The authors utilized murine models of allogeneic hematopoietic cell transplantation to assess the role of STING in hematopoietic antigen-presenting cells. [Cellular & Molecular Immunology] |
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| In naive cells, the deletion of Foxo1 following thymic development resulted in the increased expression of multiple AP-1 family members, rendering T cells less able to respond to antigenic challenge. [Cell Reports] |
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| Investigators showed that multiple synthetically accessible bryologs replicated the anti-inflammatory effects of bryostatin-1 on innate immune cells in vitro, and a lead bryolog attenuated neuroinflammation in vivo. [Cell Chemical Biology] |
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| Scientists found that Toll-like receptor 2 (TLR2) was highly abundant in the endothelium within various tissues using TLR2-IRES-EGFP reporter mice and was required for proinflammatory endothelial cell function. [Science Signaling] |
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| Researchers summarize the latest findings of ubiquitination/deubiquitination pathways for anti-tumor immunity, and discuss therapeutic significance of targeting ubiquitination/deubiquitination pathways in the future of immunotherapy. [Signal Transduction and Targeted Therapy] |
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| The authors focus on the role of the microenvironment in the acquisition and/or maintenance of stem cell states in cancer in the context of resistance and metastasis. They further discuss the role of cancer stem cells in immune evasion through the course of metastasis, dormancy, and relapse. [Trends in Cancer] |
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| Transgene announced that a first patient with head and neck cancer has been dosed with the company’s innovative individualized immunotherapy, TG4050. [Transgene (BusinessWire, Inc)] |
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| February 3 – 5, 2021 Virtual |
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| University of Luxembourg – Luxembourg City, Luxembourg |
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| Cleveland Clinic – Cleveland, Ohio, United States |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| NIH National Cancer Institute – Bethesda, Maryland, United States |
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| Stanford School of Medicine – Stanford, California, United States |
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