Immune Regulation News Volume 13.03 | Jan 29 2021

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    IRN 13.03 | Jan 29 2021

    Immune Regulation News by STEMCELL Technologies

    Vol. 13.03 – 29 January, 2021

    TOP STORY

    AIM2 in Regulatory T Cells Restrains Autoimmune Diseases

    Scientists showed that the DNA-binding inflammasome receptor AIM2 had a T cell-intrinsic and inflammasome-independent role in the function of T regulatory cells.
    [Nature]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    Hepatic
    Macrophages Act as a Central Hub for Relaxin-Mediated Alleviation of Liver Fibrosis

    Researchers showed that hepatic macrophages expressed the primary relaxin receptor, and that, on relaxin binding, they switched from the profibrogenic to the pro-resolution phenotype.
    [Nature Nanotechnology]

    Abstract

    In Vivo
    Screens Using a Selective CRISPR Antigen Removal Lentiviral Vector System Reveal Immune Dependencies in Renal Cell Carcinoma

    To avoid unwanted immune recognition, the authors designed a lentiviral vector system that allowed selective CRISPR antigen removal from tumor cells.
    [Immunity]

    AbstractGraphical Abstract

    Directional
    Mast Cell Degranulation of Tumor Necrosis Factor Into Blood Vessels Primes Neutrophil Extravasation

    Scientists demonstrated that mast cell-derived tumor necrosis factor was crucial for neutrophil extravasation to sites of contact hypersensitivity-induced skin inflammation by promoting intraluminal crawling.
    [Immunity]

    AbstractGraphical Abstract

    CTLA-4 Expression by B-1a B Cells Is Essential for Immune Tolerance

    Researchers report that expression of this immune-regulator in mouse B-1a cells has a critical function in maintaining self-tolerance by regulating these early-developing B cells that express a repertoire enriched for auto-reactivity.
    [Nature Communications]

    Full Article

    Tailoring
    the Resolution of Single-Cell RNA Sequencing for Primary Cytotoxic T Cells

    The authors demonstrated the power of high-performance in-depth cytotoxic T lymphocytes analysis by revealing the subpopulation-specific expression of co-inhibitory and co-stimulatory receptor targets of key importance for immunotherapy.
    [Nature Communications]

    Full Article

    Imaging
    Tumor-Infiltrating Lymphocytes in Brain Tumors with [64Cu]Cu-NOTA-anti-CD8-Positron Emission Tomography

    Investigators explored the ability of a humanized radiolabeled CD8-targeted minibody to non-invasively quantify tumor-infiltrating CD8+ T cells using positron emission tomography.
    [Clinical Cancer Research]

    Abstract

    Inhibition
    of MDM2 Promotes Anti-Tumor Responses in p53 Wild-Type Cancer Cells through Their Interaction with the Immune and Stromal Microenvironment

    To investigate the role of p53 in controlling tumor-immune cell crosstalk, scientists studied murine syngeneic models treated with HDM201, a potent and selective second generation MDM2 inhibitor.
    [Cancer Research]

    Abstract

    STING
    Negatively Regulates Allogeneic T-Cell Responses by Constraining Antigen-Presenting Cell Function

    The authors utilized murine models of allogeneic hematopoietic cell transplantation to assess the role of STING in hematopoietic antigen-presenting cells.
    [Cellular & Molecular Immunology]

    Abstract

    FOXO1
    Constrains Activation and Regulates Senescence in CD8 T Cells

    In naive cells, the deletion of Foxo1 following thymic development resulted in the increased expression of multiple AP-1 family members, rendering T cells less able to respond to antigenic challenge.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Designed
    PKC-Targeting Bryostatin Analogs Modulate Innate Immunity and Neuroinflammation

    Investigators showed that multiple synthetically accessible bryologs replicated the anti-inflammatory effects of bryostatin-1 on innate immune cells in vitro, and a lead bryolog attenuated neuroinflammation in vivo.
    [Cell Chemical Biology]

    Abstract

    Endothelial
    TLR2 Promotes Proangiogenic Immune Cell Recruitment and Tumor Angiogenesis

    Scientists found that Toll-like receptor 2 (TLR2) was highly abundant in the endothelium within various tissues using TLR2-IRES-EGFP reporter mice and was required for proinflammatory endothelial cell function.
    [Science Signaling]

    Full Article

    Explore scientific events this February with the Science Events Calendar.

    REVIEWS

    Targeting
    the Ubiquitination/Deubiquitination Process To Regulate Immune Checkpoint Pathways

    Researchers summarize the latest findings of ubiquitination/deubiquitination pathways for anti-tumor immunity, and discuss therapeutic significance of targeting ubiquitination/deubiquitination pathways in the future of immunotherapy.
    [Signal Transduction and Targeted Therapy]

    Full Article

    The
    Role of the Microenvironment and Immune System in Regulating Stem Cell Fate in Cancer

    The authors focus on the role of the microenvironment in the acquisition and/or maintenance of stem cell states in cancer in the context of resistance and metastasis. They further discuss the role of cancer stem cells in immune evasion through the course of metastasis, dormancy, and relapse.
    [Trends in Cancer]

    Full ArticleGraphical Abstract

    INDUSTRY AND POLICY NEWS

    First Head & Neck Cancer Patient Treated in France in a Phase I Trial with TG4050 (myvac® Platform), Transgene’s Innovative Individualized Immunotherapy

    Transgene announced that a first patient with head and neck cancer has been dosed with the company’s innovative individualized immunotherapy, TG4050.
    [Transgene (BusinessWire, Inc)]

    Press Release

    FEATURED EVENT

    AACR: COVID-19 and Cancer

    February 3 – 5, 2021
    Virtual


    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral
    Researcher – Neuroimmunology

    University of Luxembourg – Luxembourg City, Luxembourg

    Faculty
    in Immuno-Oncology

    Cleveland Clinic – Cleveland, Ohio, United States


    Postdoctoral Fellowships – Cancer Immunology

    Dana-Farber Cancer Institute – Boston, Massachusetts, United States


    Postdoctoral Fellow – Cancer Genetics and Immunology

    NIH National Cancer Institute – Bethesda, Maryland, United States


    Postdoctoral Fellow – T Cell Immunology and Transplantation

    Stanford School of Medicine – Stanford, California, United States

    > See All Jobs

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