Immune Regulation News Volume 13.05 | Feb 12 2021

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    2021-02-12 | IRN 13.05


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.05 – 12 February, 2021
    TOP STORY

    Macrophages Provide a Transient Muscle Stem Cell Niche via NAMPT Secretion

    Researchers used muscle injury models in zebrafish to systematically capture the interactions between satellite cells and the innate immune system after injury, in real time, throughout the repair process.
    [Nature]

    AbstractPress Release
    Request your free copy of the 'Human Immune Cytokines' Wallchart
    PUBLICATIONSRanked by the impact factor of the journal

    Tumor Hypoxia Represses γδ T Cell-Mediated Antitumor Immunity against Brain Tumors

    Scientists discovered that brain tumor cells had a particularly high demand for oxygen, which affected γδ T cell-mediated antitumor immune responses but not those of conventional T cells.
    [Nature Immunology]

    Abstract

    Targeted Immunotherapy for HER2-Low Breast Cancer with 17p Loss

    Investigators demonstrated that α-amanitin–conjugated trastuzumab potentiated the human epidermal growth factor receptor 2 (HER2)-targeted therapy and exhibited superior efficacy in treating HER2-low breast cancer with 17p loss.
    [Science Translational Medicine]

    Abstract

    Immune Synapse Instructs Epigenomic and Transcriptomic Functional Reprogramming in Dendritic Cells

    Scientists describe that postsynaptic dendritic cells switch their transcriptomic signature, correlating with epigenomic changes including DNA accessibility and histone methylation.
    [Science Advances]

    Full ArticlePress Release

    Sulfated Polysaccharide Directs Therapeutic Angiogenesis via Endogenous VEGF Secretion of Macrophages

    In a macrophage-inhibited mouse model, sulfated chitosan efficiently helped to recover the endogenous levels of vascular endothelial growth factor (VEGF) and the number of CD31hiEmcnhi vessels in ischemia.
    [Science Advances]

    Full Article

    Targeting IL-21 to Tumor-Reactive T Cells Enhances Memory T Cell Responses and Anti-PD-1 Antibody Therapy

    Researchers demonstrated that IL-21 could be targeted to tumor-reactive T cells by fusion of IL-21 to anti-PD-1 antibody.
    [Nature Communications]

    Full Article

    Persistence of Self-Reactive CD8+ T Cells in the CNS Requires TOX-Dependent Chromatin Remodeling

    Investigators characterized the transcriptional and epigenetic landscape of self-reactive CD8+ T cells in a mouse model of protracted central nervous system autoimmunity and compared it to populations of central nervous (CNS) system-resident memory CD8+ T cells emerging from acute viral infection.
    [Nature Communications]

    Full Article

    Augmented Antibody-Based Anti-Cancer Therapeutics Boost Neutrophil Cytotoxicity

    The authors combined the agonistic activity of IgG monoclonal antibodies and IgA Fc receptor targeting in a therapeutic bispecific antibody format.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

    Prostaglandin I2 Signaling Licenses Treg Suppressive Function and Prevents Pathogenic Reprogramming

    Using fate-mapping mice, researchers reported that prostaglandin I2 signaling prevented Treg reprogramming toward a pathogenic phenotype.
    [Journal of Clinical Investigation]

    AbstractFull ArticleGraphical Abstract

    Analysis of Classical Neutrophils and Polymorphonuclear Myeloid-Derived Suppressor Cells in Cancer Patients and Tumor-Bearing Mice

    Using single-cell RNA-seq, cell mass spectrometry, flow cytometry, and functional analysis, investigators characterized the heterogeneity of polymorphonuclear neutrophils in cancer.
    [Journal of Experimental Medicine]

    Abstract

    Dynamic Adoption of Anergy by Antigen-Exhausted CD4+ T Cells

    The authors studied CD4+ T cells in a mouse model with regulatable antigen presentation.
    [Cell Reports]

    Full ArticleGraphical AbstractPress Release

    Smectite Promotes Probiotic Biofilm Formation in the Gut for Cancer Immunotherapy

    Scientists report that smectite, a type of mineral clay and established anti-diarrhea drug, promoted expansion of probiotics in the murine gut and subsequently elicited anti-tumor immune responses.
    [Cell Reports]

    Full ArticleGraphical Abstract
    Press Release

    Learn about immunological considerations for hPSC banking by watching Dr. David Turner's webinar from the Nature Research Round Table on hPSC Quality
    REVIEWS

    RHO GTPases: From New Partners to Complex Immune Syndromes

    The authors describe the recent discovery of atypical modulators and partners of RHO GTPases, which bring an additional layer of regulation and plasticity to the control of RHO GTPase activities in the immune system.
    [Nature Reviews Immunology]

    Abstract

    Determinants, Mechanisms, and Outcomes of Myeloid Cell Diversity in Cancers

    Investigators discuss the multifaceted roles of tumor‐associated macrophages and neutrophils, focusing on factors that subvert tissue immune homeostasis and offer therapeutic opportunities for tumor microenvironment reprogramming.
    [Immunological Reviews]

    Abstract

    The Ugly Duckling Turned to Swan: A Change in Perception of Bystander-Activated Memory CD8 T Cells

    Scientists discuss the scenarios that trigger CD8 memory T cells bystander activation including acute and chronic infections that are either systemic or localized.
    [Journal of Immunology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Exscientia and the University of Oxford Announce Partnership to Develop Treatments for Alzheimer’s Disease

    Exscientia announced its collaboration with the Alzheimer’s Research UK University of Oxford Drug Discovery Institute to develop medicines targeting neuroinflammation for the treatment of Alzheimer’s disease.
    [Exscientia]

    Press Release

    Apollomics, Inc. Licenses a Targeted, Active Checkpoint Control Immunotherapy for Greater China and South Africa

    Apollomics, Inc., announced an exclusive license agreement for the development and commercialization of TYG100 in Mainland China, Hong Kong, Macau and Taiwan, also known as Greater China, and South Africa.
    [Apollomics, Inc.]

    Press Release

    FEATURED EVENT

    ACCR: Radiation Science and Medicine

    March 2 – 3, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Position – Breast Cancer

    Augusta University – Augusta, Georgia, United States

    Postdoctoral Scholar – Immune Responses in Human Skin and Mucosal Surfaces

    University of Washington – Seattle, Washington, United States

    Senior Researcher – Translational Cell Assays

    Karolinska Institutet – Stockholm, Sweden

    Postdoctoral Research Fellow – Autophagy in Prostate Cancer

    Oslo University Hospital – Oslo, Norway

    Postdoctoral Fellow – Osteoarthritis

    Oklahoma Medical Research Foundation – Oklahoma City, Oklahoma, United States

    > See All Jobs

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