Immune Regulation News Volume 13.06 | Feb 19 2021

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    IRN 13.06 | Feb 19 2021

    Immune Regulation News by STEMCELL Technologies

    Vol. 13.06 – 19 February, 2021

    TOP STORY

    Affinity-Coupled CCL22 Promotes Positive Selection in Germinal Centers

    Scientists showed that, upon stimulation of CD40, germinal center B cells upregulated the chemokine CCL22 and to a lesser extent CCL17.
    [Nature]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    CTLA-4 Blockade Drives Loss of Treg Stability in Glycolysis-Low Tumors

    Researchers found that CTLA-4 blockade promoted immune cell infiltration and metabolic fitness, especially in glycolysis-low tumors.
    [Nature]

    Abstract

    Structural
    Basis for IL-12 and IL-23 Receptor Sharing Reveals a Gateway for Shaping Actions on T versus NK Cells

    Scientists targeted the shared IL-12Rβ1/p40 interface to design a panel of IL-12 partial agonists that preserved interferon gamma induction by CD8+ T cells but impaired cytokine production from natural killer (NK) cells in vitro.
    [Cell]

    AbstractGraphical Abstract

    A
    RUNX–CBFβ-Driven Enhancer Directs the Irf8 Dose-Dependent Lineage Choice between DCs and Monocytes

    The authors demonstrated that high, low or null expression of IRF8 in hematopoietic progenitor cells promotes differentiation toward type 1 conventional DCs, Ly6C+ monocytes or neutrophils.
    [Nature Immunology]

    Full Article

    APOE
    Immunotherapy Reduces Cerebral Amyloid Angiopathy and Amyloid Plaques While Improving Cerebrovascular Function

    Investigators used 5XFAD mice expressing human APOE4+/+ that have prominent cerebral amyloid angiopathy and parenchymal plaque pathology to assess the efficacy of HAE-4 compared to an Aβ antibody that removed parenchymal Aβ but increases amyloid-related imaging abnormalities in humans.
    [Science Translational Medicine]

    Abstract

    Polyamines
    Drive Myeloid Cell Survival by Buffering Intracellular pH to Promote Immunosuppression in Glioblastoma

    Metabolic and RNA-seq analysis of tumor-associated myeloid cells (TAMCs) revealed that the arginine-ornithine-polyamine axis was up-regulated in glioblastoma TAMCs but not in tumor-infiltrating CD8+ T cells.
    [Science Advances]

    Full Article

    Relaxin
    Gene Delivery Modulates Macrophages to Resolve Cancer Fibrosis and Synergizes with Immune Checkpoint Blockade Therapy

    Scientists revealed previously unidentified insights into the modulation of macrophages to regulate tumor-associated fibrosis, providing a feasible strategy to reverse the immunosuppressive environment and improve the therapeutic outcome of checkpoint immunotherapies.
    [Science Advances]

    Full Article

    Notch2-Mediated Plasticity between Marginal Zone and Follicular B Cells

    Investigators showed induced Notch2IC-expression in follicular B (FoB) cells re-programs mature FoB cells into bona fide marginal zone B cells as was evident from the surface phenotype, localization, immunological function and transcriptome of these cells.
    [Nature Communications]

    Full Article

    HDAC
    Inhibition Potentiates Anti-Tumor Activity of Macrophages and Enhances Anti-PD-L1-Mediated Tumor Suppression

    The authors demonstrated that low-dose HDAC inhibitor trichostatin-A markedly reshaped the tumor immune microenvironment by modulating the suppressive activity of infiltrating macrophages and inhibiting the recruitment of myeloid-derived suppressor cells in various tumors.
    [Oncogene]

    Full Article

    The
    Immune-Inflammatory Response of Oligodendrocytes in a Murine Model of Preterm White Matter Injury: The Role of TLR3 Activation

    Researchers focus on toll-like receptor-3 (TLR3) that was activated by double-strand RNA and promoted neuroinflammation.
    [Cell Death & Disease]

    Full Article

    CHBP Induces Stronger Immunosuppressive CD127+
    M-MDSC via Erythropoietin Receptor

    Scientists investigated the effects on myeloid-derived suppressor cells (MDSC) differentiation and immunosuppressive function via cyclic helix B peptide (CHBP) induction.
    [Cell Death & Disease]

    Abstract

    Amylin
    Deposition Activates HIF1α and 6-Phosphofructo-2-Kinase/Fructose-2, 6-Biphosphatase 3 (PFKFB3) Signaling in Failing Hearts of Non-Human Primates

    Investigators demonstrated that in non-human primates, amylin deposition in heart failure contributed to cardiac dysfunction via activation of HIF1α and PFKFB3 signaling.
    [Communications Biology]

    Full Article

    New human primary cell products—frozen leukopaks, regulatory T cells, and more. Click to view products.

    REVIEWS

    Inflammasomes and Adaptive Immune Responses

    The authors consider how distinct tissue or cellular contexts may alter the effects of inflammasome activation on adaptive immunity and how this contributes to beneficial or detrimental outcomes in infectious diseases, cancer and autoimmunity.
    [Nature Immunology]

    Abstract

    Immunomodulation
    for Optimal Cardiac Regeneration: Insights from Comparative Analyses

    Comparing the human heart with those of animal models that are capable of cardiac regeneration reveals key differences in the innate and adaptive immune responses to myocardial infarction.
    [npj Regenerative Medicine]

    Full Article

    INDUSTRY AND POLICY NEWS

    AIM ImmunoTech Announces the Expansion of its Pancreatic Cancer Program to Include New Patients in the Netherlands

    AIM ImmunoTech, Inc. announced that the Dutch Health and Youth Care Inspectorate has approved treatment for six pancreatic cancer patients as part of a new, follow-up Early Access Program at Erasmus Medical Center in the Netherlands.
    [AIM ImmunoTech, Inc.]

    Press Release

    FEATURED EVENT

    CRISPR in Drug Discovery: From Targets to Therapeutics

    March 23 – 24, 2021
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    JOB OPPORTUNITIES

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    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow – Immunogenetics and Tumor Immunology

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

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    University of Washington – Seattle, Washington, United States

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