Immune Regulation News Volume 13.07 | Feb 26 2021

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    IRN 13.07 | Feb 26 2021


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.07 – 26 February, 2021
    TOP STORY

    Lipid Signaling Enforces Functional Specialization of Treg Cells in Tumors

    Scientists showed that inhibiting lipid synthesis and metabolic signaling that were dependent on sterol-regulatory-element-binding proteins in Treg cells unleashed effective antitumor immune responses without autoimmune toxicity.
    [Nature]

    Abstract

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    PUBLICATIONSRanked by the impact factor of the journal

    EBF1 and PAX5 Control Pro-B Cell Expansion via Opposing Regulation of the Myc Gene

    Researchers report that impaired Early B cell Factor 1 (EBF1) function in mouse B-cell progenitors resulted in reduced expression of Myc.
    [Blood]

    Abstract

    HIF2α is a Direct Regulator of Neutrophil Motility

    The authors revealed that activation of the Hypoxia Inducible Factor-2 (HIF2α) due to deficiency of HIF-prolyl hydroxylase domain protein-2 boosted neutrophil migration specifically through highly confined microenvironments.
    [Blood]

    Abstract

    Microbiota‐Driven Activation of Intrahepatic B Cells Aggravates Nonalcoholic Steatohepatitis through Innate and Adaptive Signaling

    Scientists report that nonalcoholic steatohepatitis livers accumulate B cells with elevated pro‐inflammatory cytokine secretion and antigen‐presentation ability.
    [Hepatology]

    Abstract

    Continuous Human Uterine NK Cell Differentiation in Response to Endometrial Regeneration and Pregnancy

    By surface proteome and transcriptome analysis as well as using humanized mice, researchers identified a differentiation pathway of uterine natural killer cells in vitro and in vivo with sequential acquisition of killer cell immunoglobulin-like receptors and CD39.
    [Science Immunology]

    Abstract

    Single-Cell RNA Sequencing Reveals Functional Heterogeneity of Glioma-Associated Brain Macrophages

    Investigators showed single-cell RNA sequencing of CD11b+ myeloid cells in naïve and GL261 glioma-bearing mice that revealed distinct profiles of microglia, infiltrating monocytes/macrophages and central nervous system border-associated macrophages.
    [Nature Communications]

    Full Article

    5-Fluorouracil Efficacy Requires Anti-Tumor Immunity Triggered by Cancer-Cell-Intrinsic STING

    Through modeling 5‐Fluorouracil (FU) response of murine colon and melanoma tumors, the authors report that effective reduction of tumor burden by 5‐FU was dependent on anti‐tumor immunity triggered by the activation of cancer‐cell‐intrinsic STING.
    [EMBO Journal]

    AbstractGraphical Abstract

    Astrocytes Lure CXCR2-Expressing CD4+ T Cells to Gray Matter via TAK1-Mediated Chemokine Production in a Mouse Model of Multiple Sclerosis

    Researchers used a modified experimental autoimmune encephalomyelitis mouse model that displayed severe neuronal damage to investigate the interplay between peripheral immune cells and glial cells in the event of neuronal damage.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Differential Expression of CD49a and CD49b Determines Localization and Function of Tumor-Infiltrating CD8+ T Cells

    Investigators found that tumor-infiltrating CD8+ T cells initially expressed CD49b, gained CD49a, and then lost CD49b over the course of tumor outgrowth.
    [Cancer Immunology Research]

    Abstract

    DGKA Mediates Resistance to PD-1 Blockade

    Scientists demonstrated that diacylglycerol kinase alpha (Dgka) mediated T-cell dysfunction during anti-PD-1 therapy by exacerbating the exhaustion of reinvigorated tumor-specific T cells.
    [Cancer Immunology Research]

    Abstract

    The Innate Sensor ZBP1-IRF3 Axis Regulates Cell Proliferation in Multiple Myeloma

    Investigators showed that Z-DNA-binding protein 1 (ZBP1) was selectively expressed in late B cell development in both human and mouse cells and it is required for optimal T-cell-dependent humoral immune responses.
    [Haematologica]

    Abstract

    Protein-Based Immune Profiles of Basal-Like vs. Luminal Breast Cancers

    In epithelium-enriched areas, immune signals were also detectable and varied by subtype, with regulatory T-cell markers being higher in Basal-like vs. Luminal breast cancer.
    [Laboratory Investigation]

    Abstract

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    REVIEWS

    A Double-Edged Sword of Immuno-Microenvironment in Cardiac Homeostasis and Injury Repair

    In adaptive immunity, effector T cells, especially Th17 cells, lead to the pathogenesis of cardiac fibrosis, including the distal fibrosis and scar formation. Cardiomyocytes protectors, Treg cells, inhibit reduce the inflammatory response, then directly trigger the regeneration of local progenitor cell via IL-10.
    [Signal Transduction and Targeted Therapy]

    Full Article

    INDUSTRY AND POLICY NEWS

    MaxiVAX and Minaris Regenerative Medicine Enter into a Manufacturing Partnership for MVX-ONCO-2 Cancer Immunotherapy

    MaxiVAX SA and Minaris Regenerative Medicine GmbH have entered into a manufacturing agreement for MVX-ONCO-2, a cell-based immunotherapy for the treatment of cancers such as chordoma, head and neck, and other solid tumors.
    [MaxiVAX SA]

    Press Release

    FEATURED EVENT

    Sequencing-Based Discoveries in Immunology

    March 4, 2021
    Virtual

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Position – Cancer Immunotherapy

    University of Notre Dame – Notre Dame, Indiana, United States

    Senior Scientist – Endoplasmic Reticulum on T and B Cell Biology

    University of Basel – Basel, Switzerland

    Postdoctoral Associate Position – Tumor Immunology/Immunotherapy

    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow – Immunogenetics and Tumor Immunology

    The University of Texas Southwestern Medical Center – Dallas, Texas, United States

    Postdoctoral Scholar – Immune Responses in Human Skin and Mucosal Surfaces

    University of Washington – Seattle, Washington, United States

    > See All Jobs

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