 | | Vol. 13.09 – 12 March, 2021 |
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| The authors showed that BCL6-expressing Tregs, known as follicular regulatory T cells, produce abundant neuritin protein that targeted B cells.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists demonstrated the driving role of IKZF3 in chronic lymphocytic leukemia through a B cell-restricted conditional knockin mouse model.
[Cancer Cell] |
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| Investigators used a dual-recombinase genetic mouse model of spontaneous pancreatic ductal adenocarcinoma to delete type I collagen specifically in myofibroblasts.
[Cancer Cell] |
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| Using myeloid cell–specific nanobiologics in apolipoprotein E–deficient mice, scientists found that targeting the mTOR and ribosomal protein S6 kinase-1 signaling pathways rapidly diminished plaque macrophages’ inflammatory activity.
[Science Translational Medicine] |
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| The authors developed immune-homeostatic microparticles that treat multiple mouse models of autoimmunity via induction of apoptosis in activated T cells and reestablishment of regulatory T cells.
[Science Translational Medicine] |
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| In a murine infection model, scientists observed that IFNÉ£ production by Mycobacterium tuberculosis-specific CD4 T cells was rapidly extinguished within the granuloma but not within unaffected lung regions, suggesting localized immunosuppression.
[Cell Host & Microbe] |
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| B cell acute lymphoblastic leukemia (B-ALL) cells with a low SoNar ratio had enhanced mitochondrial respiration capacity, mainly resided in the vascular niche, and were enriched with more functional leukemia-initiating cells than that of SoNar-high cells in a murine B-ALL model.
[Science Advances] |
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| The authors showed that following acute myocardial infarction in mice, CD8+ T lymphocytes were recruited and activated in the ischemic heart tissue and release Granzyme B, leading to cardiomyocyte apoptosis, adverse ventricular remodeling and deterioration of myocardial function.
[Nature Communications] |
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| Investigators built up a versatile antibody immobilization platform by conjugating anti-IgG antibody onto the nanoparticle surface.
[Nature Communications] |
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| Researchers tested HER2-targeted antibody-drug conjugates in two immunocompetent mouse tumor models.
[Cell Chemical Biology] |
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| Using two different knockout mouse strains, scientists found that Sprouty2 positively regulated extracellular signal-regulated kinase 1/2 signaling by modulating the activity of LCK.
[PLOS Biology] |
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| The authors chemically synthesized native CXCL5, truncated CXCL5, and the citrullinated versions and characterized their functions in vitro and in vivo.
[Science Signaling] |
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| | Researchers showed that neutrophil extracellular trap (NET) induction in mice treated with the lectin concanavalin A, a model of autoimmune hepatitis, resulted in cGAS-dependent stimulation of an IFN response, suggesting that NETs activated cGAS in vivopan>] |
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| Investigators explored the role of programmed death-1 in contused skeletal muscle regeneration, and to clarify the regulation of programmed death-1 on Treg cell generation and macrophage polarization
[Laboratory Investigation] |
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| Scientists discuss the cellular and molecular mechanisms of inflammatory adverse events, current approaches to treatment, as well as opportunities for the design of immunotherapies that limit such inflammatory toxicities while preserving anti-tumor efficacy.
[Cell] |
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| The authors review the underlying immunological basis of various asthma endotypes by discussing results obtained from animal studies as well as results generated in clinical studies targeting specific immune pathways.
[Cell] |
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| Investigators review the role of autophagy in inflammation, including type I interferon responses and inflammasome outputs, from molecules to immune cells.
[Immunity] |
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| Pathios Therapeutics will team up with researchers at The University of Oxford to accelerate cancer immunotherapies targeting GPR65 on immunosuppressive macrophages
[Pathios Therapeutics (Life Science Newswire, Inc.)] |
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| March 24 – 26, 2021
Virtual |
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| | University of Toronto – Toronto, Canada |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | H. Lee Moffitt Cancer Center & Research Institute – Tampa, Florida, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | The University of Texas Southwestern Medical Center – Dallas, Texas, United States |
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