| Vol. 13.12 – 9 April, 2021 |
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| Scientists identified the nuclear xenobiotic receptor CAR as a regulator of MDR1 expression in T cells that could safeguard against bile acid toxicity and inflammation in the mouse small intestine. [Nature] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors report that IL-2 – STAT5 signaling converged on an enhancer during Foxp3 induction. [Immunity] |
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| Researchers found that protective CD8+ T cells could be mobilized during viral infection even when TAP was absent in all hematopoietic cells. [Nature Immunology] |
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| Scientists employed single-cell RNA sequencing and CITE-seq to map the glioblastoma immune landscape in mouse tumors and in patients with newly diagnosed disease or recurrence. [Nature Neuroscience] |
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| Investigators report that development of T cell senescence driven by both malignant tumor cells and regulatory T cells was a general feature in cancers [Science Translational Medicine] |
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| The authors showed that mice lacking dendritic cell (DC)-SCRIPT displayed substantially impaired development of IRF8–dependent conventional DC (cDC)1, whereas cDC2 numbers increased marginally. [Science Immunology] |
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| Researchers describe a mechanism for Treg enrichment in mouse and human tumors mediated by the αvβ8 integrin. [Science Immunology] |
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| Scientists report an essential cross-talk between CAR T cell subsets and the tumor microenvironment for tumor control in an immunocompetent mouse B cell lymphoma model of anti-CD19 CAR T cell therapy. [Science Immunology] |
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| Researchers showed that the giant cell-forming potential was a particular trait of monocyte progenitors. [Nature Communications] |
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| The authors showed that UDP-glucose, a nucleotide sugar, was selectively released into the airways of allergen-sensitized mice upon their subsequent challenge with that same allergen. [Journal of Clinical Investigation] |
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| Investigators utilized T cells from mice that expressed LckS59A, which could not accept a phosphate at residue 59, to initiate acute graft-versus-host disease. [Journal of Clinical Investigation] |
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| Researchers developed a bispecific FAP-CD40 antibody, which induced CD40 stimulation solely in presence of fibroblast activation protein α (FAP), a protease specifically expressed in the tumor stroma. [Clinical Cancer Research] |
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| The authors showed that administration of recombinant IL-37 abrogated the protective effects of TI in vivo, as revealed by reduced host pro-inflammatory responses and survival to disseminated candidiasis. [Cell Reports] |
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| Scientists investigated the interaction between CD304 expression on myeloid-derived suppressor cells and galectin-1 from malignant plasma cells in the context of autologous stem cell transplantation for multiple myeloma. [Cancer Immunology Research] |
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| Investigators demonstrated that ZIP8 was specifically upregulated in CD4+ T cells that infiltrated the inflamed joint and that ZIP8 deficiency in CD4+ T cells abrogated collagen-induced arthritis. [Experimental & Molecular Medicine] |
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| Emerging evidence suggests that immunotherapy drives new immune responses rather than the reinvigoration of pre-existing immune responses. Scientists comprehensively outline the current knowledge of systemic immunity in cancer. [Nature Reviews Cancer] |
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| The deepening knowledge of tissue Treg cell biology will inform ongoing attempts to harness Treg cells for precision immunotherapeutics. [Nature Reviews Immunology] |
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| The authors summarize and discuss the versatile roles of autophagy in regulating cellular metabolism and the implications of autophagy for immune cell function and fate, especially for T and B lymphocytes. [Cellular & Molecular Immunology] |
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| City of Hope and CytoImmune Therapeutics Inc. have entered into worldwide exclusive license agreements to several patent applications related to methods to generate large numbers of fully functional natural killer (NK) cells derived from umbilical cord blood and compositions of chimeric receptors (CAR) for targeting NK cells to tumors. [CytoImmune Therapeutics, Inc. (BusinessWire, Inc)] |
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| April 21 – 23, 2021 Virtual |
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| Swiss Federal Institute of Technology in Lausanne – Lausanne, Switzerland |
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| Translate Bio – Lexington, Massachusetts, United States |
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| NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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| University of Toronto – Toronto, Ontario, Canada |
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| Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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