 | | Vol. 13.13 – 16 April, 2021 |
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| By serially transplanting glioblastoma multiforme stem cells (GSCs) into immunocompetent hosts, scientists uncovered an acquired capability of GSCs to escape immune clearance by establishing an enhanced immunosuppressive tumor microenvironment.
[Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers examined the role of interleukin (IL)-17D, a poorly understood member in the IL-17 family. Il17d−/− mice were more susceptible to acute colitis, bacterial infection and experimentally induced colon cancer than their wildtype counterparts.
[Immunity] |
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| The authors employed a multi-omics approach to deconstruct and rebuild the complex interaction of multiple cytokine signaling pathways in natural killer cells.
[Nature Immunology] |
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| Scientists showed that adoptive transfer of Treg cells largely reversed maternal immune activation-induced phenotypes.
[Nature Neuroscience] |
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| Using three different murine transgenic models, investigators provide counterintuitive evidence that the Alzheimer’s disease progression required B cells.
[Nature Communications] |
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| The authors showed that capture and engulfment of cell associated antigens by tissue resident lung type 1 dendritic cells was inhibited during progression of mouse lung tumors.
[Nature Communications] |
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| Scientists found that the Ssu72 phosphatase was activated by various T-cell receptor signaling pathways, including the T-cell receptor and IL-2R pathways, and localized at the cell membrane.
[Cellular & Molecular Immunology] |
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| Researchers found CD169+ macrophages as the predominant macrophage subtype in naive lymph nodes, which underwent proliferative expansion in response to tumor stimuli.
[Cell Reports] |
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| Investigators showed that T cell receptor-stimulated CD8+ T cells increased their expression of ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX) to enhance gene expression.
[Cell Reports] |
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| Researchers investigated the effects of nicotinamide riboside, a natural nicotinamide adenine dinucleotide precursor, on alcohol-induced inflammation and oxidative stress in macrophages.
[Laboratory Investigation] |
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| Scientists found that IFN-activated proinflammatory macrophages after neoadjuvant chemotherapy enhanced antitumor immunity but promoted cancer chemoresistance.
[Nature Cancer] |
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| Investigators examined the role of cytotoxic CD8+ T lymphocytes, a type of adaptive immune cells previously identified as amplifiers of axonal perturbation in various models of genetically mediated central nervous system (CNS) diseases.
[Nature Aging] |
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| Investigators provide a framework for navigating and selecting the appropriate biochemical techniques to explore immunometabolism.
[Nature Reviews Immunology] |
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| Scientists discuss how the immune responses to dysbiotic microbiota that cross the damaged barrier may be involved in the development of allergic and autoimmune diseases.
[Nature Reviews Immunology] |
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| The authors review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment.
[Immunity] |
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| VBI Vaccines, Inc. announced data and next steps from the high-dose cohort of its Phase Ib/IIa clinical study of VBI-2601, the company’s hepatitis B immunotherapeutic candidate, in chronically-infected hepatitis B patients.
[VBI Vaccines Inc. (BusinessWire, Inc)] |
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| May 10 – 15, 2021
Virtual |
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| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| | Boston Children’s Hospital – Boston, Massachusetts, United States |
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| | Swiss Federal Institute of Technology in Lausanne – Lausanne, Switzerland |
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| | Translate Bio – Lexington, Massachusetts, United States |
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| | NIH National Institute of Allergy and Infectious Diseases – Bethesda, Maryland, United States |
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