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| By tracking individual cells in the skin of live adult mice over time, investigators showed that Langerhans cells and dendritic epidermal T cells actively maintained a non-random spatial distribution despite continuous turnover of neighbouring basal epithelial cells. [Nature Cell Biology] |
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PUBLICATIONSRanked by the impact factor of the journal |
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| CD200R engagement inhibited activation, proliferation and type 2 cytokine production, indicating an immunoregulatory function for the CD200–CD200R axis on group 2 innate lymphoid cells. [Nature Communications] |
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| To investigate the effects of ATG14 on macrophage autophagy, human atherosclerotic plaque, apoe−/- mice and cultured mouse macrophages were evaluated. [Autophagy] |
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| DNA-methylation inhibitors have previously been shown to promote regulatory T cell responses and, in the present study, investigators evaluated their potential to ameliorate chronic and acute animal models of rheumatoid arthritis. [Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers showed that Bruton’s tyrosine kinase (BTK)-deficiency promotes inflammatory bowel disease progression in a mouse model of colitis. The increased colitis susceptibility of BTK-deficient mice was not caused by gut microbiota changes but rather arose from enhanced pro-inflammatory Th1 response. [Cell Death & Disease] |
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| The authors assessed the impact of tumor-specific CD8+ T cells on the immune response in a mouse model of cecal ligation and puncture–induced sepsis. [Journal of Immunology] |
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| Scientists employed a mouse model of carbon tetrachloride induced-acute liver injury with clodronate-induced macrophage depletion to clarify the impact of liver injury on liver metabolism and recovery dynamics of metabolic function and liver zonation during regeneration. [Scientific Reports] |
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| Gluten-specific T cells had a distinct transcriptional profile that mostly resembled that of Th1 cells but also expressed cytokines characteristic of other types of T-helper cells. [Scientific Reports] |
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| Investigators serially characterized leukocyte populations in colostrum for differential leukocyte counts. Differences in humoral and cellular composition of colostrum between 40 gilts and 40 sows from a commercial herd were examined. [PLoS One] |
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| Various isoforms of CD6 were analyzed in aged mononuclear cells and compared with young individuals. In geriatric individuals, protein and mRNA expressions of CD6 molecule/isoforms were found to be decreased compared to their young counterparts. [Biomarkers] |
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| Scientists summarize the current evidence for epigenetic regulation of immune-related pathways in cancer and describe bioinformatics tools, informative visualization techniques, and resources to help decipher the cancer epigenome. [Experimental & Molecular Medicine] |
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| The author details the immune cell subsets in afferent and efferent lymph, and explores the mechanisms by which endothelial cells of the lymphatic system regulate such trafficking, for immune surveillance and tolerance during steady-state conditions, and in response to infection, acute and chronic inflammation, and subsequent resolution. [International Journal of Molecular Sciences] |
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| Landos Biopharma announced that the company has dosed the first patient in a Phase II study of omilancor, Landos’ novel, orally administered, gut-restricted LANCL2 agonist, for the treatment of moderate-to-severe Crohn’s disease. [Landos Biopharma] |
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| Revolo Biotherapeutics announced positive data from a multiple ascending dose Phase I clinical trial evaluating the safety and tolerability of ‘1104, a first-in-class peptide for the treatment of allergic disease. The data demonstrated that ‘1104 was safe and well-tolerated at the two doses evaluated without serious adverse events. [Revolo Biotherapeutics] |
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| Case Western Reserve University – Cleveland, Ohio, United States |
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| Research Center for Molecular Medicine – Vienna, Austria |
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| Fred Hutchinson Cancer Research Center – Seattle, Washington, United States |
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| Helmholtz Zentrum München – Neuherberg (bei München), Germany |
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| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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