Immune Regulation News Volume 13.16 | May 7 2021

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    2021-05-07 | IRN 13.16


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.16 – 7 May, 2021
    TOP STORY

    Skin-Resident Immune Cells Actively Coordinate Their Distribution with Epidermal Cells during Homeostasis

    By tracking individual cells in the skin of live adult mice over time, investigators showed that Langerhans cells and dendritic epidermal T cells actively maintained a non-random spatial distribution despite continuous turnover of neighbouring basal epithelial cells.
    [Nature Cell Biology]

    Abstract
    The StemSpanâ„¢ T Cell Generation Kit is designed to promote differentiation of HSPCs into T cells in stroma- and serum-free culture conditions.
    PUBLICATIONSRanked by the impact factor of the journal

    CD200–CD200R Immune Checkpoint Engagement Regulates ILC2 Effector Function and Ameliorates Lung Inflammation in Asthma

    CD200R engagement inhibited activation, proliferation and type 2 cytokine production, indicating an immunoregulatory function for the CD200–CD200R axis on group 2 innate lymphoid cells.
    [Nature Communications]

    Full Article

    Augmenting ATG14 Alleviates Atherosclerosis and Inhibits Inflammation via Promotion of Autophagosome-Lysosome Fusion in Macrophages

    To investigate the effects of ATG14 on macrophage autophagy, human atherosclerotic plaque, apoe−/- mice and cultured mouse macrophages were evaluated.
    [Autophagy]

    Abstract

    Pharmacological Modulation of T Cell Immunity Results in Long-Term Remission of Autoimmune Arthritis

    DNA-methylation inhibitors have previously been shown to promote regulatory T cell responses and, in the present study, investigators evaluated their potential to ameliorate chronic and acute animal models of rheumatoid arthritis.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Bruton’s Tyrosine Kinase Regulates Gut Immune Homeostasis through Attenuating Th1 Response

    Researchers showed that Bruton’s tyrosine kinase (BTK)-deficiency promotes inflammatory bowel disease progression in a mouse model of colitis. The increased colitis susceptibility of BTK-deficient mice was not caused by gut microbiota changes but rather arose from enhanced pro-inflammatory Th1 response.
    [Cell Death & Disease]

    Full Article

    Tumor-Specific T Cells Exacerbate Mortality and Immune Dysregulation during Sepsis

    The authors assessed the impact of tumor-specific CD8+ T cells on the immune response in a mouse model of cecal ligation and puncture–induced sepsis.
    [Journal of Immunology]

    Abstract

    Macrophage Potentiates the Recovery of Liver Zonation and Metabolic Function after Acute Liver Injury

    Scientists employed a mouse model of carbon tetrachloride induced-acute liver injury with clodronate-induced macrophage depletion to clarify the impact of liver injury on liver metabolism and recovery dynamics of metabolic function and liver zonation during regeneration.
    [Scientific Reports]

    Full Article

    Potential Impact of Celiac Disease Genetic Risk Factors on T Cell Receptor Signaling in Gluten-Specific CD4+ T Cells

    Gluten-specific T cells had a distinct transcriptional profile that mostly resembled that of Th1 cells but also expressed cytokines characteristic of other types of T-helper cells.
    [Scientific Reports]

    Full Article

    Distribution Difference of Colostrum-Derived B and T Cells Subsets in Gilts and Sows

    Investigators serially characterized leukocyte populations in colostrum for differential leukocyte counts. Differences in humoral and cellular composition of colostrum between 40 gilts and 40 sows from a commercial herd were examined.
    [PLoS One]

    Full Article

    Compromised Levels of CD6 and Reduced T Cell Activation in the Aged Immune System

    Various isoforms of CD6 were analyzed in aged mononuclear cells and compared with young individuals. In geriatric individuals, protein and mRNA expressions of CD6 molecule/isoforms were found to be decreased compared to their young counterparts.
    [Biomarkers]

    Abstract
    Which Immune cell Are You?
    REVIEWS

    Epigenetic Dysregulation of Immune-Related Pathways in Cancer: Bioinformatics Tools and Visualization

    Scientists summarize the current evidence for epigenetic regulation of immune-related pathways in cancer and describe bioinformatics tools, informative visualization techniques, and resources to help decipher the cancer epigenome.
    [Experimental & Molecular Medicine]

    Full Article

    In Sickness and in Health: The Immunological Roles of the Lymphatic System

    The author details the immune cell subsets in afferent and efferent lymph, and explores the mechanisms by which endothelial cells of the lymphatic system regulate such trafficking, for immune surveillance and tolerance during steady-state conditions, and in response to infection, acute and chronic inflammation, and subsequent resolution.
    [International Journal of Molecular Sciences]

    Full Article
    INDUSTRY AND POLICY NEWS

    Landos Biopharma Announces First Patient Dosed in a Phase II Study of Omilancor for Moderate-to-Severe Crohn’s Disease

    Landos Biopharma announced that the company has dosed the first patient in a Phase II study of omilancor, Landos’ novel, orally administered, gut-restricted LANCL2 agonist, for the treatment of moderate-to-severe Crohn’s disease.
    [Landos Biopharma]

    Press Release

    Revolo Biotherapeutics Announces Positive Data from Additional Phase I Clinical Trial of ‘1104, its Peptide Drug for Allergic Disease

    Revolo Biotherapeutics announced positive data from a multiple ascending dose Phase I clinical trial evaluating the safety and tolerability of ‘1104, a first-in-class peptide for the treatment of allergic disease. The data demonstrated that ‘1104 was safe and well-tolerated at the two doses evaluated without serious adverse events.
    [Revolo Biotherapeutics]

    Press Release
    FEATURED EVENT

    3rd Treg Directed Therapies Summit

    May 18 – 20, 2021
    Virtual

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    JOB OPPORTUNITIES

    Research Fellow – Intestinal Stem Cells & Gastrointestinal Diseases

    Case Western Reserve University – Cleveland, Ohio, United States

    Technical Assistant – Mucosal Immunology

    Research Center for Molecular Medicine – Vienna, Austria

    Postdoctoral Research Fellow – mRNA Translation in Cancer

    Fred Hutchinson Cancer Research Center – Seattle, Washington, United States

    Research Technician – Virus Interactions in Lungs

    Helmholtz Zentrum München – Neuherberg (bei München), Germany

    Postdoctoral Position – T Follicular Helper Cell Differentiation

    University of Pennsylvania – Philadelphia, Pennsylvania, United States

    > See All Jobs

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