 | | Vol. 13.18 – 21 May, 2021 |
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| Using integrated epigenomic, transcriptomic and proteomic analyses, researchers demonstrated a novel action of CDK4/6 inhibitors in promoting the phenotypic and functional acquisition of immunological T cell memory.
[Cancer Discovery] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators generated paired single-cell transcriptomic datasets of tumor cells and the bone marrow immune and stromal microenvironment in multiple myeloma.
[Nature Immunology] |
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| The authors utilized the mouse mammary carcinoma cell line 4T1 to develop a strategy that guided an anti-programmed cell death-ligand 1 (aPDL1) antibody to accumulate in metastatic lesions to promote anti-tumor immune responses.
[Nature Communications] |
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| Researchers demonstrated that platelets were recruited into the lung together with neutrophils during the onset of inflammation and alongside Treg cells during the resolution phase.
[Journal of Experimental Medicine] |
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| Investigators found that the immune checkpoint ligand PD-L2 is robustly expressed in patient samples of ovarian cancers and other malignancies exhibiting suboptimal response to immune checkpoint blockade (ICB) but not in cancers that are ICB sensitive.
[Clinical Cancer Research] |
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| The authors investigated the relevance of galectin-1 in colorectal cancer and explored its modulatory activity within the CD8+ regulatory T cell compartment.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Genetic silencing of MDA-9/Syntenin or treatment with a pharmacological inhibitor of the PDZ1 domain, PDZ1i, activated the immune system to kill cancer cells.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors develped a screening system for innate defense regulator peptides for composite vaccine adjuvants. 4T1 mammary tumor cells were used to evaluate the antitumor activity of the alum/CpG oligonucleotide/DP7 adjuvant.
[NPJ Vaccines] |
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| Scientists examined the effect of intranasal administration of A. membranaceus polysaccharides on mucosal immune cell activation and the growth-inhibitory activity against pulmonary metastatic melanoma in mice by combination treatment with immune checkpoint blockade.
[International Journal of Biological Macromolecules] |
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| Researchers described a novel bispecific heavy-chain only antibody which bound to and activated signaling through the heterodimeric interleukin-2-2Rβγ receptor complex that was expressed on resting T cells and NK cells.
[Scientific Reports] |
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| The authors present an integrated view of fibroblast-macrophage interactions that is centered on the CSF1-CSF1R axis and discuss how additional molecular programs linking these cell types can underpin disease onset, progression, and resolution.
[Immunity] |
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| Scientists discuss the unique physiology of antibody-secreting cells and how naive B cells undergo epigenetic and genome architectural reorganization to acquire the necessary functions to support antibody production.
[Immunological Reviews] |
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| Divalent cations of two alkaline earth metals Ca2+ and Mg2+ and the transition metal Zn2+ play vital roles in the immune system, and several immune disorders are associated with disturbances of their function.
[Trends in Immunology] |
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| As wardens and housekeepers, the microglia play a central role in both monitoring and defending the brain and maintaining its normal functions. At the start of his career, German professor Marco Prinz became fascinated by these cells, which were at that time primarily thought to be the brain’s garbage collectors.
[University of Freiburg (EurekAlert!)] |
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| | University of Virginia – Charlottesville, Virginia, United States |
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| | Kings’s College London – London, England, United Kingdom |
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| | Hospital for Special Surgery – New York, New York, United States |
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| | BioMed X Institute – Heidelberg, Germany |
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| | Universit̩ Libre de Bruxelles РBrussels, Belgium |
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