 | | Vol. 13.21 – 11 June, 2021 |
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The authors generated an atlas of microRNA expression from 63 mouse immune cell populations and connected these signatures with assay for transposase-accessible chromatin using sequencing, chromatin immunoprecipitation followed by sequencing and nascent RNA profiles to establish a map of miRNA promoter and enhancer usage in immune cells.
[Nature Immunology] |
|  | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists found that high group 2 innate lymphoid cells (ILC2) infiltration in human melanoma was associated with a good clinical prognosis. ILC2s were critical producers of the cytokine granulocyte-macrophage colony-stimulating factor, which coordinated the recruitment and activation of eosinophils to enhance antitumor responses.
[Nature Immunology] |
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| Mechanistically, WSX1 transcriptionally downregulated an isoform of PI3K—PI3Kδ and thereby inactivated AKT, reducing AKT-induced GSK3β inhibition.
[Nature Communications] |
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| The authors observed monoamine oxidase A (MAO-A) induction in mouse and human tumor-associated macrophages (TAMs). MAO-A-deficient mice exhibit decreased TAM immunosuppressive functions corresponding with enhanced antitumor immunity.
[Nature Communications] |
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| Scientists reported that p53 was crucial for intestinal type 2 immunity in response to the infection of parasites. Mechanistically, p53 played a critical role in the activation of the tuft cell-IL-25-type 2 innate lymphoid cell circuit, partly via transcriptional regulation of Lrmp in tuft cells.
[Nature Communications] |
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| Researchers investigated the role of T cell function in age-related unresponsiveness to PD-1 blockade cancer therapy. They found inefficient generation of CD44lowCD62Llow CD8+ T cell subset in draining lymph nodes of tumor-bearing aged mice.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Analysis of human pancreatic ductal adenocarcinoma (PDAC) patient data from The Cancer Genome Atlas revealed a negative association between the presence of missense mutant p53 and infiltration of CD8+ T cells into the tumor.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors conducted a study to investigate the effect and mechanisms of action of surfactant protein A in OVA-induced asthmatic mice.
[Laboratory Investigation] |
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| Investigators demonstrated that prostacyclin synthase (PTGIS) was downregulated in alchoholic liver disease and forced PTGIS expression in vivo using recombinant adeno-associated viral vector-packed prostacyclin synthase overexpression plasmid, which alleviated the inflammatory response and suppressed the macrophage classically activated phenotype in mice.
[Laboratory Investigation] |
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| With a mycobacterial immunogen, scientists observed distinct functional signatures and memory phenotype in lentiviral vector- or adenovirus type 5-immunized mice, despite comparable antigen-specific CD8+ T cell magnitudes.
[Communications Biology] |
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| The authors determined anti-against phosphorylcholine and anti-malondialdehyde in brown bears in summer and winter. Paired serum samples from 12 free ranging Swedish brown bears were collected during hibernation in winter and during active state in summer and analyzed for IgM, IgG, IgG1/2 and IgA anti-PC and anti-MDA by ELISA essay.
[Scientific Reports] |
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| Researchers demonstrated for the first time a methodology allowing mouse type 2 innate lymphoid cells to be cultured, and their numbers expanded in serum-free medium supplemented with Interleukins IL-33, IL-2, IL-7 and TSLP.
[Scientific Reports] |
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| Scientists present different mechanisms by which T cells contribute to inflammaging and might act as modulators of age-associated diseases, including through enhanced pro-inflammatory and cytotoxic activity, defective clearance of senescent cells or regulation of the gut microbiota.
[Nature Reviews Immunology] |
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| After the COVID-19 era, the novel vaccine technology developed will expand to other vaccines. Investigators have been developing vaccines for chronic diseases, such as hypertension, for over ten years.
[Hypertension Research] |
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| Omeros Corporation announced preliminary results from the Phase I clinical trial of its MASP-3 inhibitor OMS906. The ongoing trial is designed as a randomized, double-blind, placebo-controlled study to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of intravenous and subcutaneous administration of OMS906 to healthy adult volunteers.
[Omeros Corporation] |
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| Sorrento Therapeutics, Inc. announced a research collaboration agreement with Mayo Clinic to conduct human clinical proof of concept studies using the sofusa lymphatic drug delivery system technology across multiple products and indications.
[Sorrento Therapeutics, Inc.] |
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| September 13 – 15, 2021
Virtual |
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| | GSK – San Francisco, California, United States |
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| | BioMed X Research Institute – Heidelberg, Germany |
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| | The Wistar Institute – Philadelphia, Pennsylvania, United States |
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| | Shanghai Immune Therapy Institute – Shanghai, China |
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| | Salk Institute – La Jolla, California, United States |
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