| Vol. 13.22 – 18 June, 2021 |
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| Investigators reported that m6A eraser AlkB homolog 5, but not FTO, maintained the ability of naïve CD4+ T cells to induce adoptive transfer colitis. [Science Advances] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| The authors evaluated effects of over 50 million single-nucleotide polymorphisms and short insertions/deletions provided by five inbred strains of mice on the responses of macrophages to interleukin-4 (IL-4), a cytokine that plays pleiotropic roles in immunity and tissue homeostasis. [Science Advances] |
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| Scientists showed that mice with genetic knockout of Ppm1d or with conditional knockout of Ppm1d in the hematopoietic system, in myeloid cells, or in neutrophils all displayed significantly reduced growth of syngeneic melanoma or lung carcinoma tumors. [Nature Communications] |
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| The authors demonstrated that PTT-induced in situ vaccination cancer therapy can elicit potent antitumor immunity against disseminated and metastatic tumors. [Biomaterials] |
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| Investigators found that the number of β7+ cells decreased significantly in tumor tissue compared with adjacent normal tissue. β7 expression decreased in tumor-derived compared to normal tissue-derived CD8+ T cells. [Cancer Immunology Research] |
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| Scientists generated a recombinant herpes simplex virus type 1 (HSV-1), HSV-aPD-1, carrying a full-length humanized anti-PD-1 monoclonal antibody that replicated and expressed anti-PD-1 mAbs in tumor cells in vitro and in vivo. [Cancer Letters] |
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| Researchers examined the upstream signaling pathways that control Tim-3–mediated increases in phosphorylated S6 in T cells. They defined the localization of Tim-3 relative to the T cell immune synapse and its effects on downstream signaling. [Science Signaling] |
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| Researchers performed a phenome-wide association study and reported that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduced GPR65 signaling, showed a significant association with atopic dermatitis, in addition to inflammatory bowel diseases and asthma, as previously reported. [Journal of Immunology] |
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| Scientists profiled gene expression in gastrulation-stage embryos from two commonly used, genetically similar mouse substrains, C57BL/6J and C57BL/6NHsd, that differed in alcohol sensitivity. [Disease Models & Mechanisms] |
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| The authors discuss synergies between antiangiogenic agents and cancer immunotherapy based on results from preclinical and translational studies. [Cancer Communications] |
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| Investigators review the role of steroidogenesis in regulating inflammation and immunity, discuss the unresolved questions, and how this area can bring another golden age of steroid hormone research with the development of new tools and technologies and advancement of the scientific methods. [Genes & Immunity] |
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| FibroGen, Inc. and HiFiBiO Therapeutics, a private, multinational clinical-stage biotherapeutics company with expertise in immune modulation and single cell science announced a partnership covering three HiFiBiO programs. [FibroGen, Inc.] |
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| Kytopen announced it was awarded a SBIR Fast Track grant from the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institute of Health. Kytopen is eligible for up to $2M over the course of the three-year award as project milestones are successfully completed within the Phase I and Phase II portions of the grant. [Kytopen] |
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| September 13 – 15, 2021 Virtual |
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| Institute of Oncology Research – Bellinzona, Switzerland |
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| Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| European School of Molecular Medicine – Milan & Naples, Italy |
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| BioMed X Research Institute – Heidelberg, Germany |
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| The Wistar Institute – Philadelphia, Pennsylvania, United States |
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