Immune Regulation News Volume 13.22 | Jun 18 2021

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    2021-06-18 | IRN 13.22


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.22 – 18 June, 2021
    TOP STORY

    m6A Demethylase ALKBH5 Controls CD4+ T Cell Pathogenicity and Promotes Autoimmunity

    Investigators reported that m6A eraser AlkB homolog 5, but not FTO, maintained the ability of naïve CD4+ T cells to induce adoptive transfer colitis.
    [Science Advances]

    Full Article
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    PUBLICATIONSRanked by the impact factor of the journal

    Mechanisms Underlying Divergent Responses of Genetically Distinct Macrophages to IL-4

    The authors evaluated effects of over 50 million single-nucleotide polymorphisms and short insertions/deletions provided by five inbred strains of mice on the responses of macrophages to interleukin-4 (IL-4), a cytokine that plays pleiotropic roles in immunity and tissue homeostasis.
    [Science Advances]

    Full Article

    Inhibition of the DNA Damage Response Phosphatase PPM1D Reprograms Neutrophils to Enhance Anti-Tumor Immune Responses

    Scientists showed that mice with genetic knockout of Ppm1d or with conditional knockout of Ppm1d in the hematopoietic system, in myeloid cells, or in neutrophils all displayed significantly reduced growth of syngeneic melanoma or lung carcinoma tumors.
    [Nature Communications]

    Full Article

    PolyTLR7/8a-Conjugated, Antigen-Trapping Gold Nanorods Elicit Anticancer Immunity against Abscopal Tumors by Photothermal Therapy-Induced In Situ Vaccination

    The authors demonstrated that PTT-induced in situ vaccination cancer therapy can elicit potent antitumor immunity against disseminated and metastatic tumors.
    [Biomaterials]

    Full Article

    Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Anti-Tumor Immunity

    Investigators found that the number of β7+ cells decreased significantly in tumor tissue compared with adjacent normal tissue. β7 expression decreased in tumor-derived compared to normal tissue-derived CD8+ T cells.
    [Cancer Immunology Research]

    Abstract

    Enhanced Anti-Tumor Response Elicited by a Novel Oncolytic HSV-1 Engineered with an Anti-PD-1 Antibody

    Scientists generated a recombinant herpes simplex virus type 1 (HSV-1), HSV-aPD-1, carrying a full-length humanized anti-PD-1 monoclonal antibody that replicated and expressed anti-PD-1 mAbs in tumor cells in vitro and in vivo.
    [Cancer Letters]

    Abstract

    The Costimulatory Activity of Tim-3 Requires Akt and MAPK Signaling and Its Recruitment to the Immune Synapse

    Researchers examined the upstream signaling pathways that control Tim-3–mediated increases in phosphorylated S6 in T cells. They defined the localization of Tim-3 relative to the T cell immune synapse and its effects on downstream signaling.
    [Science Signaling]

    Abstract

    pH and Proton Sensor GPR65 Determine Susceptibility to Atopic Dermatitis

    Researchers performed a phenome-wide association study and reported that the T allele of GPR65-intronic single-nucleotide polymorphism rs8005161, which reduced GPR65 signaling, showed a significant association with atopic dermatitis, in addition to inflammatory bowel diseases and asthma, as previously reported.
    [Journal of Immunology]

    Abstract

    Transcriptomic Analyses of Gastrulation-Stage Mouse Embryos with Differential Susceptibility to Alcohol

    Scientists profiled gene expression in gastrulation-stage embryos from two commonly used, genetically similar mouse substrains, C57BL/6J and C57BL/6NHsd, that differed in alcohol sensitivity.
    [Disease Models & Mechanisms]

    Full Article
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    REVIEWS

    Improving Antitumor Immunity Using Antiangiogenic Agents: Mechanistic Insights, Current Progress, and Clinical Challenges

    The authors discuss synergies between antiangiogenic agents and cancer immunotherapy based on results from preclinical and translational studies.
    [Cancer Communications]

    Full Article

    Revisiting Steroidogenesis and Its Role in Immune Regulation with the Advanced Tools and Technologies

    Investigators review the role of steroidogenesis in regulating inflammation and immunity, discuss the unresolved questions, and how this area can bring another golden age of steroid hormone research with the development of new tools and technologies and advancement of the scientific methods.
    [Genes & Immunity]

    Full Article
    INDUSTRY AND POLICY NEWS

    FibroGen and HiFiBiO Announce Transformative Partnership to Advance Next-Generation Therapies for Patients with Cancer and Autoimmune Disease

    FibroGen, Inc. and HiFiBiO Therapeutics, a private, multinational clinical-stage biotherapeutics company with expertise in immune modulation and single cell science announced a partnership covering three HiFiBiO programs.
    [FibroGen, Inc.]

    Press Release

    Kytopen Awarded NIH Grant of Up to $2M to Unlock the Power of Engineered Natural Killer (NK) Cells via Flowfect® Platform

    Kytopen announced it was awarded a SBIR Fast Track grant from the National Institute of Allergy and Infectious Diseases (NIAID), a part of the National Institute of Health. Kytopen is eligible for up to $2M over the course of the three-year award as project milestones are successfully completed within the Phase I and Phase II portions of the grant.
    [Kytopen]

    Press Release
    FEATURED EVENT

    Virus Genomics and Evolution

    September 13 – 15, 2021
    Virtual

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    JOB OPPORTUNITIES

    Postdoctoral Fellow – Cancer Pathogenesis

    Institute of Oncology Research – Bellinzona, Switzerland

    Postdoctoral Fellow – Immunology or Bacteriology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Student – T Cell-B Cell Interactions

    European School of Molecular Medicine – Milan & Naples, Italy

    Postdoctoral Position – Protective Tissue Factors in Autoimmune Diseases

    BioMed X Research Institute – Heidelberg, Germany

    Program Co-Leader – Immunology

    The Wistar Institute – Philadelphia, Pennsylvania, United States

    > See All Jobs

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