| Vol. 13.24 – 2 July, 2021 |
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| Scientists found that resident macrophage deficiency prevents storage of lipids in adipocytes from wild-type and Ccr2–/– mice fed a high-fat diet, as well as hyperphagic leptin receptor–deficient mice. [Science] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Mice with constitutive activation of mechanistic target of rapamycin complex signaling in osteocytes exhibited a dramatic increase in IL-19 production and promyelocyte/myelocytic expansion, whereas mechanistic target of rapamycin complex inactivation in osteocytes reduced IL-19 production and neutrophil numbers in mice. [Blood] |
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| CD8+ T cells significantly infiltrated 12-dimethylbenzanthracene (DMBA)-exposed breast cancers. CD8+ T cell depletion resulted in severe lung and liver metastasis in DMBA-treated polyoma middle tumor-antigen transgenic mice. [Science Advances] |
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| A protease-activated prodrug form of the anti-mouse CD137 agonist antibody 1D8 was constructed and found to be selectively activated in the tumor microenvironment. [Proceedings of the National Academy of Sciences of the United States of America] |
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| The authors reported that Riok3, an atypical kinase, negatively regulated retinoic acid-inducible gene-I-like receptors sensing-induced type I IFN signaling. [Cell Reports] |
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| In wild-type (WT) muscle, investigators observed an upregulation of PN-1 mRNA and protein after ischemia. Angiography analysis showed that femoral artery perfusion was more rapidly restored in PN-1−/− mice than in WT mice. [Scientific Reports] |
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| Intravenously treating with single strain for three times, or with both strains alternately for three times significantly reduced the tumor size and prolonged the survival time of model mice. [Scientific Reports] |
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| Scientists presented a platform to study the tumour-immune interaction using a co-culture between cancer spheroids and activated immune cells. [Antibiotics] |
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| The authors discuss the emerging understanding of radiotherapy-induced immune effects with particular focus on the lungs and gut and the potential immune crosstalk that occurs between these tissues. [Nature Reviews Immunology] |
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| Scientists summarized recent findings on the heterogeneous subset composition of B cells in both human and mouse tumor models and their different impacts on disease progression. [Oncogene] |
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| Takara Bio, Inc. announced that it has entered into a License and Supply Agreement with BioNTech Cell & Gene Therapies GmbH under which Takara Bio grants BioNTech a commercial license to use applicable patents relating to RetroNectin®. [Takara Bio, Inc.] |
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| August 6 – 7, 2021 Marysville, Victoria, Australia |
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| Roswell Park – Colorado Springs, Colorado, United States |
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| Weill Cornell Medical College – New York, New York, United States |
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| Research Center for Molecular Medicine – Vienna, Austria |
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| Hummingbird Bioscience – Singapore, Singapore |
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| University of Gothenburg – Gothenburg, Sweden |
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