Immune Regulation News Volume 13.24 | Jul 2 2021

    0
    113






    2021-07-02 | IRN 13.24


    Immune Regulation News by STEMCELL Technologies
    Vol. 13.24 – 2 July, 2021
    TOP STORY

    Diet-Regulated Production of PDGFcc by Macrophages Controls Energy Storage

    Scientists found that resident macrophage deficiency prevents storage of lipids in adipocytes from wild-type and Ccr2–/– mice fed a high-fat diet, as well as hyperphagic leptin receptor–deficient mice.
    [Science]

    Abstract


    This webinar provides insights and techniques for efficient leukopak sample processing and streamlined cell isolation.
    PUBLICATIONSRanked by the impact factor of the journal

    Osteocytes Regulate Neutrophil Development through IL-19: A Potent Cytokine for Neutropenia Treatment

    Mice with constitutive activation of mechanistic target of rapamycin complex signaling in osteocytes exhibited a dramatic increase in IL-19 production and promyelocyte/myelocytic expansion, whereas mechanistic target of rapamycin complex inactivation in osteocytes reduced IL-19 production and neutrophil numbers in mice.
    [Blood]

    Full Article
    Graphical
    Abstract

    CD8+ T Cell Immunity Blocks the Metastasis of Carcinogen-Exposed Breast Cancer

    CD8+ T cells significantly infiltrated 12-dimethylbenzanthracene (DMBA)-exposed breast cancers. CD8+ T cell depletion resulted in severe lung and liver metastasis in DMBA-treated polyoma middle tumor-antigen transgenic mice.
    [Science Advances]

    Full ArticlePress Release

    Antitumor Efficacy and Reduced Toxicity Using an Anti-CD137 Probody Therapeutic

    A protease-activated prodrug form of the anti-mouse CD137 agonist antibody 1D8 was constructed and found to be selectively activated in the tumor microenvironment.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Abstract

    Riok3 Inhibits the Antiviral Immune Response by Facilitating TRIM40-Mediated RIG-I and MDA5 Degradation

    The authors reported that Riok3, an atypical kinase, negatively regulated retinoic acid-inducible gene-I-like receptors sensing-induced type I IFN signaling.
    [Cell Reports]

    Full ArticleGraphical Abstract

    Protease Nexin-1 Deficiency Increases Mouse Hindlimb Neovascularisation following Ischemia and Accelerates Femoral Artery Perfusion

    In wild-type (WT) muscle, investigators observed an upregulation of PN-1 mRNA and protein after ischemia. Angiography analysis showed that femoral artery perfusion was more rapidly restored in PN-1−/− mice than in WT mice.
    [Scientific Reports]

    Full Article

    Combination Immunotherapy with Two Attenuated Listeria Strains Carrying Shuffled HPV-16 E6E7 Protein Causes Tumor Regression in a Mouse Tumor Model

    Intravenously treating with single strain for three times, or with both strains alternately for three times significantly reduced the tumor size and prolonged the survival time of model mice.
    [Scientific Reports]

    Full Article

    An Integrated Framework for Quantifying Immune-Tumor Interactions in a 3D Co-Culture Model

    Scientists presented a platform to study the tumour-immune interaction using a co-culture between cancer spheroids and activated immune cells.
    [Antibiotics]

    Full Article

    Alison O’Mahony developed a model to qualify immuno-oncology drugs in vitro. Watch the webinar.
    REVIEWS

    Immunomodulation by Radiotherapy in Tumor Control and Normal Tissue Toxicity

    The authors discuss the emerging understanding of radiotherapy-induced immune effects with particular focus on the lungs and gut and the potential immune crosstalk that occurs between these tissues.
    [Nature Reviews Immunology]

    Abstract

    B Cell Heterogeneity, Plasticity, and Functional Diversity in Cancer Microenvironments

    Scientists summarized recent findings on the heterogeneous subset composition of B cells in both human and mouse tumor models and their different impacts on disease progression.
    [Oncogene]

    Abstract

    INDUSTRY AND POLICY NEWS

    Takara Bio Enters into a License and Supply Agreement of RetroNectin® with BioNTech Cell & Gene Therapies GmbH

    Takara Bio, Inc. announced that it has entered into a License and Supply Agreement with BioNTech Cell & Gene Therapies GmbH under which Takara Bio grants BioNTech a commercial license to use applicable patents relating to RetroNectin®.
    [Takara Bio, Inc.]

    Press Release

    FEATURED EVENT

    Melbourne Immunotherapy Network (MIN)

    August 6 – 7, 2021
    Marysville, Victoria, Australia

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Associate – Translational Immunology and Immunotherapy

    Roswell Park – Colorado Springs, Colorado, United States

    Postdoctoral Position – Modeling Autism Spectrum Disorder

    Weill Cornell Medical College – New York, New York, United States

    Postdoctoral Positions – Cellular, Molecular and Digital Medicine

    Research Center for Molecular Medicine – Vienna, Austria

    Senior Research Scientist/Principal Scientist – Immunology

    Hummingbird Bioscience – Singapore, Singapore

    Postdoctoral Fellow – B Cell Immunology

    University of Gothenburg – Gothenburg, Sweden

    > See All Jobs

    Submit an article, publication, job or event
    Brought to you by
    stemcell-logo-for newsletter-2
    Immune Regulation News Twitter