 | | Vol. 13.25 – 9 July, 2021 |
| |
|
|
| The authors showed that the cytidine diphosphate–ethanolamine pathway co-ordinated the expression and localization of CXCR5 with the responses of T follicular helper (TFH) cells and humoral immunity.
[Nature] |
|
|
|
 | | PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| The rational design of an injectable in situ polymeric aggregate-embodied hybrid nitric oxide (NO)-scavenging and sequential drug-releasing gel platform for the combinatorial treatment of rheumatoid arthritis by incorporating a “clickable” NO-cleavable cross-linker was reported.
[Advanced Materials] |
|
|
|
| To specifically trigger sufficient antitumor reactivity without notable adverse effects, scientists developed an antigen and adjuvant codelivery nanoparticle vaccine based on Escherichia coli cytoplasmic membranes and tumor cell membranes from resected autologous tumor tissue.
[Science Translational Medicine] |
|
|
|
| Investigators developed a microscopy-based, automated 3D interface coculture model suitable for medium-throughput screening to delineate the steps and cytotoxic T lymphocytes effector mechanisms affected by microenvironmental perturbation.
[Cancer Immunology Research] |
|
|
|
| The construction of a 1,3-propanesultone-grafted zwitterionic dendrimer-entrapped gold nanoparticle platform chelated with Gd(III) for immune checkpoint modulation is reported.
[Advanced Healthcare Materials] |
|
|
|
| Gene set enrichment analysis was used to calculate scores of immune pathways for hepatocellular carcinoma, and hierarchical clustering in two databases. The scores of the immune microenvironment and the proportions of 22 immune cells were also calculated.
[Molecular Therapy-Nucleic Acids] |
|
|
|
| The authors co-fermented collagen peptide-jackfruit juice was used in immunosuppressed mice to evaluate the immune response and gut microbiota modulatoration.
[Food Chemistry] |
|
|
|
| A signature was constructed by 11 immune-related prognostic long non-coding (lnc)RNAs from the competitive endogenous (ce)RNA network. The survival analysis and receiver operating characteristic analysis validated the reliability of the signature.
[Aging-Us] |
|
|
|
| Researchers demonstrated that YIV-906 plus anti-PD1 could eradicate all Hepa 1–6 tumors in all tumor bearing mice. YIV-906 was found to have multiple mechanisms of action to enhance adaptive and innate immunity.
[Scientific Reports] |
|
|
|
| Scientists generated IL11 knockout (Il11−/−) mice that were born in expected ratios and have normal hematological profiles. Lung fibroblasts from Il11−/− mice were resistant to pro-fibrotic stimulation with TGFβ1.
[Scientific Reports] |
|
|
|
| The authors investigated the role and mechanisms of enhancer of zeste homolog 2 (EZH2) in pulmonary fibrosis in a murine model of LPS-induced ARDS and in ex vivo cultured alveolar macrophages and mouse lung epithelial cell line by using 3-deazaneplanocin and EZH2 the small interfering RNA.
[Respiratory Research] |
|
|
|
| To illustrate the role of Rank-RankL in Th17 differentiation, naive CD4+ T cells were differentiated into T helper 17 cells with or without RankL stimulation.
[Immunological Investigations] |
|  |
|
|
|
| Scientists summarize new insights in bile acid physiology, focusing on regulatory roles of bile acids in the control of immune regulation and on effects of pharmacological modulators of bile acid signaling pathways in human liver disease.
[Seminars in Immunopathology] |
|
|
|
| Although IgE responses are normally constrained, recent studies suggest that specific conditions can induce the formation of IgE responses with enhanced affinity or longevity, effectively ‘breaking the rules’ of IgE regulation.
[Current Opinion in Immunology] |
|
|
|
|
| Australia’s leading breeder and supplier of lab mice and rats is preparing to close its doors, leaving researchers scrambling for alternatives. The closure “would have major implications for Australia’s medical research effort,” says Malcolm France, a Sydney-based veterinarian who advises institutions on the care and management of animals used in research.
[Science nsider] |
|
|
|
| Developmental biologist and immunologist Maria Leptin will be the next president of the European Research Council, (ERC) the ERC’s Scientific Council announced. Leptin will take over in October from Interim President Jean-Pierre Bourguignon, who has been leading the ERC since Mauro Ferrari resigned from the post in April 2020 after a dispute over how the organization should fund research on COVID-19.
[The Scientist] |
|
|
|
| Alector, Inc. and GlaxoSmithKline plc announced a strategic global collaboration for the development and commercialization of two clinical-stage, potential first-in-class monoclonal antibodies designed to elevate progranulin levels.
[Alector, Inc.] |
|
|
|
|
| August 1 – 2, 2021
Brisbane, Australia |
|
|
|
|
|
| | University of North Dakota – Grand Forks, North Dakota, United States |
|
|
|
| | Medical College of Wisconsin – Milwaukee, Wisconsin, United States |
|
|
|
| | Roswell Park – Colorado Springs, Colorado, United States |
|
|
|
| | Weill Cornell Medical College – New York, New York, United States |
|
|
|
| | Research Center for Molecular Medicine – Vienna, Austria |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
