 | | Vol. 13,26 – 16 July, 2021 |
| |
|
|
| Given the well-established role of CD4 T cells in sustaining germinal centers (GCs) and the emerging role of Foxp3 in suppressing this reaction, scientists sought to determine whether expression of Foxp3 by GC-resident T cells could also play a role in GC longevity.
[Science] |
|  |
|
|
| PUBLICATIONSRanked by the impact factor of the journal |
|
|
|
| Researchers exploited the power of a visceral adipose tissue (VAT)-Treg TCR-transgenic mouse model to follow the dynamics of, and phenotypic changes in, the VAT-Treg population throughout the development of diet-induced obesity.
[Cell Metabolism] |
|
|
|
| The authors provided evidence that the SUMO protease SENP1 promoted T cell memory development via Sirt3 deSUMOylation. SENP1-Sirt3 signaling augmented the deacetylase activity of Sirt3, promoting both OXPHOS and mitochondrial fusion.
[Nature Communications] |
|
|
|
| Investigators showed that inhibition of the hyperactive mevalonate (MVA) metabolic pathway in tumor cells elicited type 1 classical dendritic cells-mediated tumor recognition and antigen cross-presentation for antitumor immunity.
[Cancer Research] |
|
|
|
| At the earliest stages of T cell development, cells with random chromosome gains and/or losses were selected against, but chromosomal instability eventually resulted in the expansion of progenitors with clonal chromosomal imbalances.
[Genes & Development] |
|
|
|
| Lymphocytes from Nur77GFP transgenic mice express a fluorescent protein upon activation via the TCR, allowing the differentiation of activation mode in a natural repertoire of immune cells and antigens.
[Stroke] |
|
|
|
| Researchers showed that a combination immunotherapy platform utilizing low dose chemotherapy combined with oncolytic virotherapy increased tumor-infiltrating lymphocytes, in otherwise immune-bare tumors, allowing 60% of mice to achieve durable tumor regression when treated with immune checkpoint blockade.
[Communications Biology] |
|
|
|
| The authors observed fewer tumor foci in Ncf1 mutant mice, irrespective of αβT, γδT, B-cell deficiencies, or of a functional Ncf1 expression in CD68-positive monocytes/macrophages.
[Communications Biology] |
|
|
|
| Sensitized BALB/c mice were challenged with aerosolized ovalbumin (OVA) to establish allergic inflammation, followed by RSV-A2 infection to yield four treatment groups: saline only, RSV-infected alone, OVA alone, and OVA-treated with RSV infection
[Respiratory Research] |
|
|
|
| Investigators attempted to verify angiotensin-converting enzyme 2 (ACE2) expression in the nasal mucosa of patients with seasonal allergic rhinitis induced by Japanese cedar pollen and chronic rhinosinusitis with nasal polyp and to examine the effects of short-chain fatty acids on ACE2 expression in airway epithelial cells.
[American Journal of Rhinology & Allergy] |
|  |
|
|
|
| The authors review CD8+ T cell differentiation to dysfunctional states during tumorigenesis.
[Nature Reviews Immunology] |
|
|
|
| Scientists discuss the initiation and resolution of inflammation, the crosstalk between tumor development and inflammatory processes.
[Signal Transduction and Targeted Therapy] |
|
|
|
| Investigators summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.
[Trends in Immunology] |
|
|
|
|
| The Food and Drug Administration announced a new warning for the Johnson & Johnson coronavirus vaccine, saying the shot has been linked to a serious but rare side effect called Guillain-Barré syndrome, in which the immune system attacks the nerves.
[The Washington Post] |
|
|
|
| The US government is investing heavily to breed more monkeys at the national facilities that house primates for biomedical research, Nature has learnt. The goal is to offset an ongoing shortage of these animals, which grew worse in 2020 as scientists tested scores of COVID-19 vaccines and treatments on primates before trials began in people.
[Nature News] |
|
|
|
| The Lupus Foundation of America has renewed its support for the National Institutes of Health (NIH) Accelerating Medicines Partnership (AMP) which recently announced a new initiative to discover the causes of inflammation and clinical disease. The new AMP Autoimmune and Immune-Mediated Diseases (AMP AIM) Program will use novel analytics to examine the interaction among innate and adaptive immune cells and tissue-resident cells.
[The Lupus Foundation of America] |
|
|
|
|
| August 19 – 20, 2021
Zurich, Switzerland |
|
|
|
|
|
| | Memorial Sloan Kettering Cancer Center – New York, New York, United States |
|
|
|
| | University of Wisconsin–Madison – Madison, Wisconsin, United States |
|
|
|
| | Tübingen University – Tuebingen, Germany |
|
|
|
| | University of Pittsburgh – Pittsburgh, Pennsylvania, United States |
|
|
|
| | Roswell Park – Colorado Springs, Colorado, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
