 | | Vol. 13.28 – 30 July, 2021 |
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| The authors described a new autoregulatory loop whereby ThPOK bound to the SilThPOK to maintain its own long-term expression in CD4 T cells.
[Nature Immunology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers uncovered an immune-endocrine regulatory circuit that mediated cross-talk between peripheral B-cells and progenitors in the bone marrow, to balance B-lymphopoiesis in both human and mouse aging.
[Blood] |
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| Scientists demonstrated that the loss of Pax5 by conditional mutagenesis in peripheral B lymphocytes led to the strong reduction of B-1a, marginal zone and germinal center B cells as well as plasma cells.
[Science Immunology] |
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| Conditional deletion of mitochondrial transcription factor A in RORγt+ lymphocytes significantly affected systemic γδT17 cell maintenance and reduced group t3 innate lymphoid cells without affecting T helper 17 cells in the gut.
[Nature Communications] |
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| Investigators reported that agonists of the immune regulator stimulator of interferon genes (STING) confered remarkable protection against cancer pain, bone destruction, and local tumor burden.
[Nature Communications] |
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| The authors discovered that selective recruitment and activation of systemic CD8+ T cells into DNA mismatch repair colorectal cancers strictly depended on overexpression of CCL5 and CXCL10 due to endogenous activation of cGAS/STING and type I IFN signaling by damaged DNA.
[Journal of Experimental Medicine] |
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| Researchers mechanistically and functionally linked CD38 and (leucine-rich repeat kinase 2) LRRK2 as upstream activators of transcription factor EB (TFEB), a host defense transcription factor and the master transcriptional regulator of the autophagy/lysosome machinery.
[Autophagy] |
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| To understand the different facets of immune-tumor collaboration through genetics, spatial transcriptomics, and immunological manipulation with non-invasive, longitudinal imaging, the authors generated a penetrant double oncogene-driven autochthonous model of neuroblastoma.
[Cancer Research] |
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| In a syngeneic model that reflected the mutational landscape of castrate-resistant prostate cancer, macrophage depletion resulted in a reduced transcriptional signature for steroid and bile acid synthesis, indicating potential perturbation of cholesterol metabolism.
[Cancer Research] |
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| Investigators showed that Treg-expressed CTLA-4 facilitated Treg-antigen-presenting cells conjugation and immune synapse formation.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers found that although NK cells did not express endogenous TYRO3 on the cell surface, activated NK cells rapidly acquired TYRO3 from tumor cells via trogocytosis in vitro and in vivo.
[Cancer Immunology Research] |
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| The authors investigated a non-IgE-mediated food-allergic enteropathy model of ovalbumin (OVA) 23-3 mice expressing OVA-specific T-cell-receptor transgenes.
[Mucosal Immunology] |
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| Scientists showed that butyrophilin-like suppressed homeostatic proliferation of γδ intraepithelial lymphocytes preferentially in the ileum.
[Communications Biology] |
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| Investigators summarize reports in the literature regarding the roles of peripheral and reflex cholinergic neuroinflammatory pathways of nicotinic acetylcholine receptors in reprogramming preeclampsia complications in mothers and their progenies.
[Biochemical Pharmacology] |
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| The authors summarize the current literature regarding the basic immunological mechanisms mediated by IL-1β in the different phases of allergic contact dermatitis (ACD) and highlights potential IL-1β-targeted treatment options, which in the future may be relevant in the treatment of patients with ACD.
[Contact Dermatitis] |
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| Beyond Celiac announced the granting of a two-year established investigator grant award to the University of Sheffield, United Kingdom. The $209,000 investment from Beyond Celiac will make it possible for scientists to expand investigation of the neurological and neuropsychological manifestations of celiac disease and gluten-related disorders.
[Beyond Celiac] |
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| Revolo Biotherapeutics announced receipt of Clinical Trial Authorization by the Medicines and Healthcare Products Regulatory Agency in the UK to evaluate safety and efficacy of its first-in-class peptide for the treatment of allergic disease, ‘1104, in a Phase II allergen sensitivity study.
[Revolo Biotherapeutics] |
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| October 27 – 29, 2021
Virtual |
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| | Harvard Medical School​ – Boston, Massachusetts, United States |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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| | University of California Irvine – Irvine, California, United States |
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| | Baylor College of Medicine – Houston, Texas, United States |
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| Columbia University Medical Center – New York City, New York, United States |
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